ID A0A0V0WJR5_9BILA Unreviewed; 811 AA.
AC A0A0V0WJR5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 6 {ECO:0000313|EMBL:KRX75742.1};
GN Name=FGD6 {ECO:0000313|EMBL:KRX75742.1};
GN ORFNames=T06_13616 {ECO:0000313|EMBL:KRX75742.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX75742.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX75742.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX75742.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX75742.1}.
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DR EMBL; JYDK01000116; KRX75742.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WJR5; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13389; PH1_FGD5_FGD6; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 170..353
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 382..479
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 521..579
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 625..729
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 485..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 93506 MW; 9E9A5FA23004B588 CRC64;
MVSGVGYVDS SEFLLMRSAV PPPVPPKPLH LVEKYRHLRN SPLRAVRPAP APPIFGDRKS
NVQCDDKRRV TLPVLVKSQS FHRWHSENAL HQSSSCNSLR HSFSFGDLSL SRRSSKWRKS
LLKKLNENRR YNYLPGHDSY FSERSSGVYS ASESSEEEEI IYQEPQQKDK LYRVAEEMCR
TEWAYVNTLK ALSVDFPKFI ESQSLINQRL LVQPDVSNEI ARHLHALRKL HLEIAERLQS
RLDSWASRPQ IADILLKVGH FLKMSRMFLQ QKEELATQLI QNCRQYPDFA AAKKHFGGLL
LVHQLDCVHQ RICRYPLLLS TYLKYCSPNL EEYKSALEAK RLLESVALEI EHGLVEGDNL
RKMFHLQRRL YSDYEIIQPG RKLLKEGEVM KHSRKEIHPR FLVLFNDILL YCAPVVHGSS
MLRVRNVLPL ETLDMPVLPK NDATSKEFHL RSQRRSIIIL AKSLSERDEW IKAVKEAMQM
SKSRFSDSNL TLEQSENSSV HGDKQSPTEE IGRKAPPWVP DDRVTMCQHC ITPFTTLRRR
HHCRACGKVI CRRCIGKAPL EYADFSVEIV CPLCYDILLN RSFGADASSK IFSPEFLKCN
MFFPPRCRVE QKKSSNGNLI SLDDDCVMKG YVWHQRKRDA WKRYWCILRK DSVMEFYAAS
EDKVCKWKVV LISYEALKIR GVEGLPDMLE ISHKNQVMTT QSQSLKMVLK GDTNEITHNW
YNAVKSVLID FEDAFCCNES SVTDLSKKMQ GGISRRTSGD KSRKITLRTV LSSIYNDPFQ
WSVVKSALMF SVGVYVANVL SSIDTFDSVS P
//
