ID A0A0V0WK14_9BILA Unreviewed; 904 AA.
AC A0A0V0WK14;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glutamate receptor 1 {ECO:0000313|EMBL:KRX75960.1};
GN Name=glr-1 {ECO:0000313|EMBL:KRX75960.1};
GN ORFNames=T06_8229 {ECO:0000313|EMBL:KRX75960.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX75960.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX75960.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX75960.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX75960.1}.
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DR EMBL; JYDK01000111; KRX75960.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WK14; -.
DR STRING; 92179.A0A0V0WK14; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06380; PBP1_iGluR_AMPA; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF544; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRX75960.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006871726"
FT TRANSMEM 578..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..821
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 457..522
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 904 AA; 103506 MW; 2FD91F0CBC6A6859 CRC64;
MFHVKWILFL LFNHANGNLR VPVGALFRDE MEDGLISVMT YATMENNYQQ SPPPFRLETK
KGIIRTDSVN NWALTRLGCE VIKDGAFVLM GTANYPSREA FVALSNLLHL PLINWSTAKR
ESQNGQFEIS MAQNTAEAVG DFIRLKMWKN FTYMYDSIDG LYEYELLNNY LKKTGTEVRT
QMLYLKNIEP DYFRFFLNFH SSRFASDSYV ILHISNRKKL KFILRDLLDA AMKTKNFHYL
ISGQEVLDAE IENFKIGLIN VSGFQYEGRD KSSFKDFLEK WSRLDSQLLH YHKASTITAE
EALVYDAIQI VIEAFKSIAK VNASALKRYY KKDEFINEDY HGLLCYTFED KLNPDRPFLP
LRHGEMMYDA LKKTRLDGIS GNVQFDNDGN RVNYTLKLTE VLQTGHNAGV VNVQKRLWRQ
KAGFQNGENH PQKGEKINKN IQPFNRTRII TTIINEPFVM FKKDADQFTG NDRFEGFCVD
LMKLLSEKIE NFPYIIKPVK DNQYGAVDQN GRWNGMVGEL IRGEADLAIA SLTINTLRER
VVDFSKPFLT TGISIMIKKP DKQEFSIFSF MQPLSTEVWI FIIIAYGGVS IVIFFIARFS
PYEWNYNQSS TYGCTSLSDF TIDNCLWVTL AALMQQGTDI MPRLMISASC RIASSIWWFF
TMIIVSSYTA NLAAFLTLEK MHAPIESVED LARQTKIKYG IQASGSTAQF FKESKVDVHR
RMWQYMSTQV PSPLVSSYAE GIQRVRESKG QYAFLLEATT NEYASTRKPC DTIKVGANLN
SIGYGVATPF GSDLSEKINL AILELQEIGE LKRLEMKWWY EKGQCEQGMS DSQSASLTLS
KVAGIFYILT VGIIIAMLVS FVEIFYYLNA EKHSKIPSEP FCIQSAVENY GKAEMLTNSK
EITT
//
