ID A0A0V0WS60_9BILA Unreviewed; 1160 AA.
AC A0A0V0WS60;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Integrin alpha ina-1 {ECO:0000313|EMBL:KRX78560.1};
GN Name=ina-1 {ECO:0000313|EMBL:KRX78560.1};
GN ORFNames=T06_14511 {ECO:0000313|EMBL:KRX78560.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX78560.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX78560.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX78560.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX78560.1}.
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DR EMBL; JYDK01000065; KRX78560.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0WS60; -.
DR STRING; 92179.A0A0V0WS60; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1109..1133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 29..90
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 325..387
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 395..451
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 462..524
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 509..688
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 692..840
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 846..1095
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1160 AA; 131313 MW; C076C985F44597FF CRC64;
MDSESIYLSC IILHILNFCT YSLAFNLDTD MPVYKIGPKD TYFGFAVAQH MKGDEPLILI
GAPKAESGQV GTKHAGAMFA CPVNSVFNNV SETPTSKWCQ NSRVEYPSFA FDEVDFYKHA
PNKVRPEDIY TKDHQWLGST IRSSGRGSRV LVCAPNLIYG SAAYIEGACF LLKNDLTHVK
RIRTCQFFTK KNRHNDYSVC QEGFSATLDE KYQVIATGLP GASRWIGGMF AQDIDEHLST
LHARWTPMVR GNHTVENVIK AHSYFGYSTA VGIFGFAHEN FKPNGNFTLV AGCPRCNDTG
AVYFLPFYKE VTVDQYSALR LFHDHMNLTG DESFASGFGY SITVMDIDQD GFDDLIVGAP
YHYNFSSTKP TGGRVYVYFS SGKVQPSDKN KFVFKEPIRL SGSMDSMFGA ATANLGDLNE
DNFNDLAVGA PYDEGGGAVY IYFGSSAESF DSKPMQIIRG NELKITNPLL NPIQTFGWSL
SGGLDMDNNG YPDLLVGAFK SDMAILLRAR PIVHIVTTVE EEDLKPIDLD HQRCKNYWEK
FYNRKNIIIP TVCCILYFCS FKFRTKLRIR RQTIGSQLDF TRNILLCRLE VLRHGSALKR
AEFSGKFNYH KEWPCGRGAV DSAQIQEHEL FIRDTNRDWL NPLKFVFSVA LLTDKPKLAT
SPLSTIPNIN DYPVLDKIGS QTEFTLEFNK KCGNDDQCIS DLVLNCLLVN LAKEASSDMY
VKQVGKDDEL DLHYRVTNKG ERAYESSLFV KYNENELERP MLLQKSHNLL NFGKLKNGLI
EVLLGNPLEP NAEVVFQLKF KLTRGRSETL GKPLVFESFV NSTSTEVDES NNRCKVAVKV
IKKAELEIVG ISKPKLVYFG GKVFGESSVF YEEDIGPQVI HTYLVKNSGP WGVSDVTVMI
EHPHQIYSPY ARGKWALYLM YTPVIELPIP GSAITETRNC YVDLMAEHVN PLDVKIGSAE
DDDGMSELEK PTRKPSSKYT TTALQFVQSL RDFRIRQEVV NIDGETYKRV VVNCNKQPEK
RTAKCFPIRC IIDHLEPNIT ATIRILSRLW NSTFVEDYRD VDHVLVESRA WIEVDRRQGI
EETNYLDNEA TAVTRAQPDM PQIEEKLKIP LWIIILAVLG GIFLLMLITV LLWKCGFFKR
GKYYDQPLYK AEYKHSEDID
//
