ID A0A0V0X7W7_9BILA Unreviewed; 2208 AA.
AC A0A0V0X7W7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Plexin-A4 {ECO:0000313|EMBL:KRX84092.1};
GN Name=PLXNA4 {ECO:0000313|EMBL:KRX84092.1};
GN ORFNames=T06_11084 {ECO:0000313|EMBL:KRX84092.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX84092.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX84092.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX84092.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX84092.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDK01000008; KRX84092.1; -; Genomic_DNA.
DR STRING; 92179.A0A0V0X7W7; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2208
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006872378"
FT TRANSMEM 1438..1459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1641..1659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..615
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1337..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2129..2208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1463..1490
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1344..1362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2132..2208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2208 AA; 244964 MW; 71DC5111FECB65D5 CRC64;
MRLVEFLIFL FVFSDWLGGG RGFVRGSLLW LVTATSFGSI GGSESGSSTG LDHYYNSLGL
VRDFTRLRYG NQGGHCPSEL TKRNLHDHQL DRRQQFPNQL NRDRRECLSA WHGADGGGFV
GTGPVGRRSL LWAMHRQFIK FFTIPQTVHF NGCGTQSSSQ TENGVSGGEG GDGFFLVEVV
ERLYTGRVYV AGVNRLYQLN SNLLLQSQVE TGPARDGTIC TDDPACDPRT RLSDNYNKAL
AIYHKQTKLI VCSSLYDGHC RLRNLYNISV VDDRVVDQNV VSGDLTASAV LFVNKGPNDE
DVLYVGRTGK HGNSDRLTAV KTLSLNPDQL FNSVYKGVSS ESSLVYYTDL EMHRVDYIYG
FGSGNFSYFV TKQPKLPGGR TPYISKLVRL CNRDPHYYSY TEVPLECIDD NNGGVDYNLV
QSAYLGKAGF DLARDLNINT EDDVLYVIFV RGVNEPVRAQ MTRQSALCVY SMKAVEQRFL
DNVQLCAQGV SMCGLAHQQR PCISTHYSMS ALLCNNEVNH PLDGSLPVRQ KPAFTTDDSR
LTAVASTTTH MYTVLFLGTE DGQLKKVVVE TATSAYQYDT FRVESGWPIL PSIDFDMSNQ
FLYVLTNRSL SKVRVHECIR HERCQQCLNA RDPYCGWGSL ENKCSTQEDC KSSHWLPYKD
SKCTSLTKVV PDKIQITTAK FLELTVQNFP AVSGQLSCVF TIGTKKLITG ASGPIDQAIS
CPTPQTNLLP PIPRDQHELK ALLSIQVDDG PDFAAINFTF YDCSNYRSCH DCVNSDFGCD
WCAESAQCTA SAAEQCRGQL LVNGMMSKTT TGRRRGAALF CPHIVAQDQR TILVPSGTVT
AVTVRAVNLL DFQKEFTCEF SIGNAVHRRP ASRLGDLIQC DQMEFSYFDP EPNVTAGFSV
TWAPGKALDN VHNIGVVMYK CERLASNCGL CLHLPASYGC GWCTGGQQQS CTINSKCDVG
GSGSQRRWLH HRDTCPNPTI VKFWPTAGPV DGGTRLTIEG VNLGRDYSEI ENAVRIKNVV
CTPIAELYEP STRIVCITGP AKHRKTQSGP VVVKIRDVMD YVAVSDQDFR YVVAEIGGFT
PTSGPQSGGT VLTIRGNHLN AGSRITATVG GVPCHVLSLE PRRALCRTGA SSLAGRTGGV
EMRFDNAVAT YASQQFTFEE DPAVLVVSPQ RSIVSGGVEV DVRGERFHLV QRMTMHFTLQ
DRQTSRSECT ILTADQALCR TPALGPLIDQ HLYPQPDRPL LVDYGFSMDG VDSANNLSSK
SGFRPFSVYP DPEFELFQSS TGGTTGTTLP VKYFKNDYLT INGNNIDLAV NERDVRIYVG
AELCNLTALA SRAVTCKPPD KQPPSALGQQ QQQQQQQFHR PASTVVGNQQ LSSLEIHRGS
TSSTSTSMLA NQRAAVVATL PEVVVSVGGR NYTIGYLSYD DPSSSETALF GSWPAKTVAT
VAAVLALFVG VVLVLLLLYR RKSTKQRRQM RSLKEQIDAI ELKVANECKE AFAELQTDIA
TEWTADTTTK AGIPFLPYKD YVLQVLFPNS TGQASSFLRL EPDLAPRSDR RSRGAVEKGL
LQFNQLLMNK TFLLTLVRVL ESNKYFLSKD RVYVGSLLMV ILHERMDYCT DILKTLLAAL
IERTVRSRHQ PKILFRRSES VAERMLAAWF TFLMHKYLLD CAGQPLFTLY WAIKQQVEKG
PQDATTFDAR YSLSEEKLIR QTVDFHPLVV YVSNGFDSSP ASSSSSAAAA AAAMVAATAT
GSSEVAVRVL DCDTITQVKE KCLDAIYRTT PYSRRPSALE LDLEWRTGVS GRLVLQDLDV
TTKPEPGGWK RLNTLAHYKV PNNASLALVA KQSSMYNLSL LSERSDKSST FSLKNSPTLA
RAFSPGKESS SDSGYKIYHL VKPHDHYYHH HHHHQADIGG VERVGGKMVS EIYLTRLLTT
KGTLQKFVED LFEAIFSTAH RGNTLPLCIK YMYDFMDDQA AQHGILDPEV VHTWKSNSLP
LRFWVNLIKN PHFVFDIPRP AKIEGCLSVV AQTLMDSCST QDPQLTKDSP SSKLLFARDI
HSYREWVERY YMDVRDLPVI SDQDMNAFLV EESRQQLTEF NVLGALQELY KYVNQYKDQL
LAALEEDEFS RRNRLPAKFV QMQRIFDGEE QHHSMQQQQQ QQQQSTTALA AGSNMINTNN
SNPYPANPYI VSPSTLKVIN PSSASASSSN QHAGDNNSTS NNSSQAFA
//
