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Database: UniProt
Entry: A0A0V0XAX5_9BILA
LinkDB: A0A0V0XAX5_9BILA
Original site: A0A0V0XAX5_9BILA 
ID   A0A0V0XAX5_9BILA        Unreviewed;       421 AA.
AC   A0A0V0XAX5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   31-JUL-2019, entry version 14.
DE   SubName: Full=Ligand-gated ion channel 50 {ECO:0000313|EMBL:KRX84958.1};
GN   Name=lgc-50 {ECO:0000313|EMBL:KRX84958.1};
GN   ORFNames=T06_12584 {ECO:0000313|EMBL:KRX84958.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX84958.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX84958.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX84958.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX84958.1}.
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DR   EMBL; JYDK01000003; KRX84958.1; -; Genomic_DNA.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054673};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    421       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006872540.
FT   TRANSMEM    242    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    305    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       37    241       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      250    335       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      337    357       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   421 AA;  48534 MW;  4537DCEE75B0924B CRC64;
     MLGGVVWMVL LCLVGAQLEN SVADDFTTLE SCANDSTIID LLLKSNLYNK HRVPDPNGVV
     VMVEFWVQEI SSVSELTSDF EMDIYVNEIW MDKALRFDAM NPCKQNITLS HHVFDKIWTP
     NSCFINSKMA SIHDSPFRNI YLTVYSNGTV WTNYRVKVRG PCSMDLSSFP LDKQKCTLIY
     QSFNYNSDEV KMRWGEGKVF QMKQFSLPDF DLVNISTRVE IHISPAGVWD ELYVTFTFQR
     RYVWYVLQAY IPTYLTIFIS WVSFTLGPYA IPARTMLGVN SLLAMIMMFG NIMRNLPRVS
     YVKAIDVWML ACMTFNFCSL LELAVIGYLT KNATPNELPN RRQTDDTKRS CPRPTSSGFL
     MRHPWRQEGG AGPTRTYCFQ KCWSLLGPVY MAEKIDRASC FAFPALFSLF NIAYWSYYMN
     S
//
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