ID A0A0V0XGW7_TRIPS Unreviewed; 3374 AA.
AC A0A0V0XGW7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Pecanex-like protein {ECO:0000256|RuleBase:RU367089};
GN Name=Pcnxl3 {ECO:0000313|EMBL:KRX87238.1};
GN ORFNames=T4E_814 {ECO:0000313|EMBL:KRX87238.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX87238.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX87238.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX87238.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU367089}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU367089}.
CC -!- SIMILARITY: Belongs to the pecanex family.
CC {ECO:0000256|ARBA:ARBA00010170, ECO:0000256|RuleBase:RU367089}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX87238.1}.
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DR EMBL; JYDU01000299; KRX87238.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd14297; UBA2_spUBP14_like; 1.
DR Gene3D; 3.90.950.10; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR003697; Maf-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR041432; UBP13_Znf-UBP_var.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR12372; PECANEX; 1.
DR PANTHER; PTHR12372:SF7; PROTEIN PECANEX; 1.
DR Pfam; PF02545; Maf; 1.
DR Pfam; PF05041; Pecanex_C; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR Pfam; PF17807; zf-UBP_var; 1.
DR SMART; SM00165; UBA; 1.
DR SMART; SM00290; ZnF_UBP; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52972; ITPase-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU367089};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|RuleBase:RU367089};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367089};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 158..181
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1104..1125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1174..1194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1206..1226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1270..1289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1295..1315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1450..1469
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1475..1495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT TRANSMEM 1588..1609
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367089"
FT DOMAIN 2736..2850
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT DOMAIN 2892..3371
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 3231..3278
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 258..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2350..2377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2488..2534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3221..3243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3285..3310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1362..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2370
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2488..2509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2516..2534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3287..3305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3374 AA; 373950 MW; 3F1EEEFC4EC8EEE6 CRC64;
MKILLSFQFQ RQRTFGLHGC RIIGKKFVEK FCEVTKLQFG DLSSELIDAY VESGESFDKA
GAYSIQDSAA ALVRAIDGDF YNVMGFPLHR VKSTMATSTH PINFLRQGVW ASITGGWFYD
PGQTLFCNTL HMYIWLFLFA TPLLLSMFFY FTWPLLVVYV LSAGLLFTAV KLTVWTLNYI
FDKHEPIQKC SSLSLDEVEP ADGRHRRMHS RAAAAIVGRH GAMPDLDDAS LAGVIVKPRR
HSSSFSCSNA DVEVEVDDAM MQSNDFMPSS RSGSSSSSSS SSSSSSTSSP SLSSSSSHSA
SAFSVSATSS PSAANTTTTI TATATTTNAA IHAIPSNVRD KRRAISKVGR GFRCQNCQNR
KLAAQGIAVE AEVHDKPQPI SAGVNIFASC DEELRRAVGY LHSQHSSASS LMLFENTLLR
YRQGRKECIS GSVDVLNATS GRGRPFSDSS TVYRSKQAIC EESCDDQAPV GIHAGGGGLR
PTLCRVHSDC LPVGADRDSS LFFGRARVLS DDQGRQRASN LERRNPNLXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXA SAGTSSVGTV ANAEAGMQQA ALENDDSVDS VLPLVQSLKS
ICREEKNLML GNEERARLIE EIKRLLEEII DFHPEALEAI ESIRRAKKLG SNGERTRSSR
TDFLNSLVAE ADEDEAEEKK NLTTTSQQQQ QQSRRSYYDG GSSSSNKRAD DHHLEIEVEV
EEAEEAERDR GRFRAAARCA AGIGFDEQLA ALDEEEKSKK ALLISRVQPG NHMAASHDDT
SEGAVHCFQD QDGHWWTYTF CSSGTGTAQS LGTGQEMERR VRRFCESHYI GSPSPSSRQA
SARRTAAAAA AAAAAASLER GNVASSSSDE SLLAVMPSMV LRPDASLSLS GNDPTAVATR
FNNVVHLTTA VDDDASSMAV RNSLSSRLRS FDAHFARLAD SRPMFHSHRR RRQRPTAGVI
RTGAGASSIV SCGRNCRQQQ QQQQQQPFEM QLAQSVVGMG RGPGTSSGRP VETLGSLANY
HPDTFSLPGR AAVRSSMGHV RVLGNVALLF RRHRNTTPAR QDRKKQYYRV PVFSALFGHE
RRRFVNIHFD RLRLSSLFDP NQRWSFICLD VLLAMLVCSI TFLLIRQRYY YDFGVLFLCC
SSAGAQFSLL KSVQPDAASP VHGHNSIIPY SRPVYFSLIG LAILLLEPIS ITLLEPTLLA
TVQPALQLLH VLLIRLLLFL PLVFTFGLLP QLDTFLCHLF EQIDMHIFGG TAVFNLRSAV
YALTRSLVSV MLLSAVLYPT LSSCFFSTAS SASTASQSVA FSAFCGLLVS LAYLLSRLSS
DPRPLVSLFN QIFSTLGNLI SRRKVGGDNC ARRRHRRSAS ASSVRRRSEE QAAVEERDEQ
QQQQQQQQQQ QQQQQQQQRD SNNQSQHHHY YKHDDDDDDD DDDDNIPYDD SVDWNQQIAS
LSMHRCKNSL FVSCLIGLLA FAIHCSTVFS KFRFAFGVVW PLLTVFVGLV IHCLLPQLRQ
HTPCLLLAQP VLKAREYGLF DVSSVAKLMW FERLYAWLCC LERHVLYPTA LLSMLTEIVT
AWQVSDDVSK LRPSQPASQH QSLQYQQLLF TAVLFSITVA GLKLLRLAFA NPSSLYIPLA
LSLLITFVDG VVSRENLLFS LYTFSILYPK LRELVLKLRF IFAYVAPWQI SWGSAFHAFA
QPCAVSHSAF TLIIAAVSSL LSAPLNPFMG SSVFLMSYVR PVKFWEKDYN TKRVDHSNTR
LINQLAGQPT TDDSSLNAIF YEHLTGCLRD CLAGDLMLGR FASEVEPGDC FILASFYLNC
LIHVVEIGNG FVSFQLRGLE FRGTYCQQRE VEAITEELNE VDSHGPVTAG GVTGSGTSTG
PGPGPGTGGG GANTATATGT STAAAGGVIT SATPAQRAGG NGRRRCCRSP SSSSSSSTCC
CCCYYYYYCC CCCRCGANSM NTDRICRLPG FLTLSSLWNV RWLAWEIKTA KYILDGYSVS
ENSAISLFQL IELRKLLVTL YVKSIIYYTV RSPKLSDWLR SEPILEALQL IESNPIYVDV
DTTFCFSNDE DYDIRRSGIS RESFSNVYIP WIACCWKRSN STYAGFEWSH FQQSENLITL
CYALSLFGRR LLGAASQTHH TTNAESFLYG LYALFKGDFR ITCTRDEWVF SDMEILASII
GPAVRMAVKL HQDHFTFADD LEDEACLYAV ITFEDSSIFI SHENDPNWRR AVLSNTPKLL
ALRHVSEDGQ DDFKIIMLNK RHVSFRVIKL NRECVRAFWA GQQQELIFLR NRNPERGSIQ
NARQVLRNII NSSADQPIGY PIYVSPLTTS YCETHPQLSK VLGPDLLSMF GRKCFSLWQQ
LRLNCGMRGS SSAANANHHH HHHYRHHHHH QQDTTTTTYP CRTAATTVGR CPSTTAVPTH
GRVQLSTFSS TSSASAFTSS QVASHSNTSL PLLGTSGSTV PSVVLQRSFT LPVDRAASRR
SGCKSETAAL ISAAAAAAAA DATTSTTTTT TTTTTTTTRR TTFSKRFISD NASPVMDKMS
LKSSTSTSTS GSSSSSPSHR YCQCVISTGE QGMQATFSNI SRVPPSQQHQ QQQQNLHVEK
SVSQMDEIAY VAPERGSPIY KDECVFCFDS PEFEHGLYIC LICHVGVCRN HVLMHVTRTD
HVGYLNLIRE KKLLIDDDAA PPKQITKLAI GVESGFLEKR YEVRERWAVS VYPQLELVPL
LESTLGPGLL YCCKAIMEAE SAYRLLEVQS QAGTWDGTML KDTIHTNLLQ LDNPPKIPPS
GWRCQAEGCD KTDNLWLNLT DGMIFCGRKL WDGGGGNNHS MDHYCKTGYP LSVKLGTISS
NGADVFSYDE DDLVNDPQLE KHLKHFGIDL AAMEKTEKSM IELELDFNQK WEFHEIQEEG
NKLTPVYGPG YTGMVNMGNS CYLNSVIQAL VMIPDIVRVY WDGADRIFRN CSLVPCDDFN
VQFAKVVSGL LSGRYSRADL EVYLRNILFF LLYTERRGIR PAAFRLLINR GNAEFASNRQ
QDVEEFMRYL FELLEQNKRG IGCVDVVSAW RFSLQEKLTC LESGNVSYKQ RPEVILSLPV
PLLGLEQQQI DDRSSPLVND ENRPPSVVVV PVEPTQLSMM NGAGDVGNDA VAAATGVNTT
TTTRLESGVI GPKLRPTVSL MDCLKALVEP ELLDNTKSPF TGRISSMEKQ LHFNTFPDWL
WIQMKKFTFA PDWRPLKLDV SIAVPDLLDM NEFRGSGPHV GKLTMEYTKD SDDEQQPSAN
PELMSQLMDM GFAEADVRTA LIETANNLEI AVQWLLSGGV DGQGGQGAGG LNNSSRSSND
VPPSSEVQFR DGDGLYRLRG FISHIGSSAH TGHYVCHLLK GEQWIIYNDE KVALSEKPPK
DLGYVFLYER ISTD
//
