ID A0A0V0XJ89_TRIPS Unreviewed; 1726 AA.
AC A0A0V0XJ89;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN Name=Polr1a {ECO:0000313|EMBL:KRX88044.1};
GN ORFNames=T4E_6681 {ECO:0000313|EMBL:KRX88044.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX88044.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX88044.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX88044.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX88044.1}.
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DR EMBL; JYDU01000253; KRX88044.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 342..675
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1406..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1726 AA; 196070 MW; A116FA535CE78E20 CRC64;
MLSQKLKCQA DCNTLNSAGF DILTPEEVLE ISVKEITAPN AFDALYHPIA GGLCDPAFGP
VDYMECCATC SFTGAQCPGH YGHIRLPLPM FNPLLFDITY QLIRGTCFVC HRLFVADNEV
ALKTFFAQME ALDEGNLALA LEIADISTAV FSELCVSDSL NLQYLKDSEN SVKESVLKER
LEELKKNCSV QNRIFLIQFD HNCLFSHSGK ANSKGNLEIT KNVSQVRREL ISEFCTNFLY
RRIKQCPSCA SQVTGIRNIG KRAIILTLPS KKGALKNKNN DLLKNSNNKY VHSNQRYVSA
AEVCSHLQMV WKNGGESILS SIFPMFKTRK NLQYADGFIP TDLLFLTHLL VMPPKFRPIV
ELAGRKYDNP ISQIYRNIIE DCLSIKRFMQ KATADKWQTE GSESVDAVQD NEEQIQTLCL
TMQSHVNELY DNNETSRIAS GLTVQLNAKG LRQVLEKKEG LFRKHMMGKR VNFAARSVIA
PDPYMSVDGV GIPEVFAKRL SFPEAVFSAN ATAMCEAVLH GPDVHPGANF LIDERGVKIH
LNAGKEIERS GMAKRLLQTS QRFGIAYPKK VCRHLKENDF VLLNRQPTLH KPSIMAHKVK
VLKNQRTLRL NYATCKTYNA DFDGDEMNAH FPQNEIARAE CSEIADVARQ FLVPKDGKPI
AGLIQDHVVS GFMLTMRDKF LTKEDFNYLL LSAFPSVEHP WRQVPPTIFK PVRRWTGKQV
VTTILLNVIP SHLPPINLVT KAKTSIKNWT VAGKREPIFE LSESNVVICS GELLCGVLDK
AQMGASPYGL VHCIFELYGP AVAAKLLSCF SRLFTTYLQM RGFTLGVEDI MLTRKADSKR
RKLLSTVDSC GSEAVREALA LEAEIEEDEV KLILAEKHFK NEKESLLRVE QCFRQATDKF
NDQANKICFP NGLLKAFPDN GLSLMIETGA KGTSVNFFQM SCMLGQVDLE GQRVKVGMSG
RTLPCFQRYD TKPRAGGFVS QRFLSGVRPQ EFFFHCLAGR EGLIDTAVKT SRSGYLQRCI
IKHMEGIIAN YDLTVRDADG SIIQFYYGED GFDVTKSQFY DRTHLPFLHA NIDVLEQTSR
DLPNFENEDN LIAEKRFAKI KRWKEKYEKC QEVESTVHKS QLAFLPNVED SSKEQLVMAW
FECPVEERRR WLKQCAKWRP DPVMSTLRPT TCIGALSDKF LEQLDNFIEE RQATIDKSVQ
KFAKLMKLRG MRSLVEPGET VGLLAAQSIG EPSTQMTLNT FHFAGCGEMN VTLGIPRLRE
ILISGSATIS TPTSRVQFRQ GVSRELAEDV QRRMNRIVLN QVLEFANQME FVTTDGYSCY
CILHADWAKF REYEITLKLS KRRKRPYSVR HLDSRTIMAK IEQSFFRSLC FSLKKMFDSG
NKFREVEMLH IENENEINEN EDALTFAGGN DQESSEEDDD NDVDAVQAQQ RQRHKDDNEY
LGEDEEAIEL NLLTSGESCL FDSTGESIVR QNSNSEEIRP AKDDDEQHLP LDQYRVKVMV
VEQDSLITDY SYDSKRNHWC KATVKVPFKY GAIDMRYLVE EECSKFVVQS VRDIKRCMLT
EENGELFLIT EGINLKVFTE RPDIFNVNRI YCNNIHTMAS MYGIEAAARS IIRETKNVFA
SYGIEVDHRH LSLLSDYMTH TGKYYSFSRN YMNSSTSPFQ KMSFETTVNY MKEALTRRTL
DKMQTPSANL VVGRLPRFGT GFFEVLALLP SITTAEDRNV ETEVQQ
//
