ID A0A0V0XJS3_TRIPS Unreviewed; 682 AA.
AC A0A0V0XJS3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Neurogenic locus notch-like protein 2 {ECO:0000313|EMBL:KRX88110.1};
GN Name=NOTCH2 {ECO:0000313|EMBL:KRX88110.1};
GN ORFNames=T4A_13839 {ECO:0000313|EMBL:KRY79499.1}, T4C_9403
GN {ECO:0000313|EMBL:KRZ44168.1}, T4E_8463 {ECO:0000313|EMBL:KRX88110.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX88110.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|Proteomes:UP000054632, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS13 {ECO:0000313|EMBL:KRY79499.1}, ISS141
RC {ECO:0000313|EMBL:KRX88110.1}, and ISS176
RC {ECO:0000313|EMBL:KRZ44168.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX88110.1}.
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DR EMBL; JYDU01000250; KRX88110.1; -; Genomic_DNA.
DR EMBL; JYDR01000001; KRY79499.1; -; Genomic_DNA.
DR EMBL; JYDV01000007; KRZ44168.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0XJS3; -.
DR STRING; 6337.A0A0V0XJS3; -.
DR Proteomes; UP000054632; Unassembled WGS sequence.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR Proteomes; UP000054826; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF498; PROTEIN EYES SHUT HOMOLOG-RELATED; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..682
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007437704"
FT TRANSMEM 648..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 380..416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 418..454
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 456..495
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 497..536
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 538..572
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 574..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 406..415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 444..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 485..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 526..535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 562..571
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 600..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 682 AA; 76297 MW; 586735813C20C1D0 CRC64;
MKMVHTSRIV LTVSIALFFA SSILSDQELF KWCHTFGGVS PSDAYQKESG EIICLYRLKV
EYKNNDWWES AAWDCYNMHQ SSSLYDFESI EIYESAFIIN FNNKLTTVKK EAVVGPKLYT
NIQVNKASSV GYNYIVSLLM VSPGRKVEMC SFAKDVQESW IKLNGSCVTS NLLLQETLKV
QSVNDSLCEY FFYDNIDSSK LKMDDVYFWP AKCNEEVTMS YDIYAICQVP SAKDLCKHSL
LGNDTCRECV GNRRGPYCEI MSDDCISELC PNAKSCVLKV GAEGVTWREP FPRWDCICRE
QYTGRLCDQR IDESDSQVAG YYFGGRCRMG FTGRFCETLI DDCSEVTGTN ILSCEYLELG
APYCFCLCKD GFAGPRCELI DNLCLRNPCK NAIKCEMGFK KYKCYCKAGF TGKHCEMNID
ECESNPCLNR GTCVDGDDGY TCLCRRGFEG PRCAGKLSPC QDNPCRNGGR CREIPNGNLP
YTCICSEGYY GDRCENAYIS CHSESCMRPH GRCVELKGKP SYTCICSPGY GGDQCEGYAS
VCFAKCYHGK CIENILGFSC DCSPGFTGKN CLTELDECEA GLCKNGGICI DEVNSYRCVC
HPPYTGENCE QLITTSMVVR TVLSTTTEAP KRPTVFAKKL LDIDQDTIYI AMIVALAALL
FALLVSLFYI LCGQLSEDSL SE
//
