ID A0A0V0XJV6_TRIPS Unreviewed; 4025 AA.
AC A0A0V0XJV6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=prkdc {ECO:0000313|EMBL:KRX88117.1};
GN ORFNames=T4E_500 {ECO:0000313|EMBL:KRX88117.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX88117.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX88117.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX88117.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX88117.1}.
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DR EMBL; JYDU01000250; KRX88117.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX88117.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3605..3935
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3993..4025
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 4025 AA; 461645 MW; FDB80289F98E78A6 CRC64;
MAYSTVDRIR DALNSLKDFI EGADSDQAED CVQQIFNHFH KLNGSERNFG FCFNSLLSND
SNSLLSILSS SIGKTAFAQT IVYGIDIIRL AIAKTTSLSP SHRKAIMRFT LRLLKQDYLK
GRREVVLYLA NECIKYSSVL STESEELNFC YDELLHCCLA LIDSLKKLQN GVKKGLFIII
GSLCQEIPEK LITADYNYAL LFANIMSEEL KNQMCSSIHS PSYSVIEGCF LGLNDLLAHF
SNLFDGACRM SCSELFNLIK KACNPKNDVH RLGHLKAALS LFISRVQFFR HHFLDEYSLL
NECFSHWAKH YDREIKTYSL NAEDLLIREL ATELITKVDS DPNHVRSVYK YFCNQFDEIF
SNTSGIREIS MISKSYGRLF QIGKALYGEE EVCKVLRKLL QRFEYLSTTS SDAQQQNVYH
ITNILEAASR GLLCLSKIAD DVWQLVERFH VTLFHNFPLM EKRFYHRCKV INVATFAAAY
GHNYQYIQSI VFQSLIRVIA SLPSVGKESI VLAKDENTFH LADYLPFWKM LLDSEFVDLS
EFGFDRAMQV NIQRTLFDCF MKSFLEIVRL LSFETKAFQD VEEYTFRFGN PVFNVIPTKQ
ADYDLFYNLV ELCRSVIMNG SHVLFEPWLQ PMLTMLLELS SRYPMVSGFY KLLAVWVTMA
EKLNYFNYTE QDKTENCNSH YKLLLSDFID HVLVESCRFQ GELLVSCLRF LLALPTCIVV
EKLESIKEAI KSSLKLGLNY LPIACVCMDA LEKWSAEFPE DEPQLDSFYT DLLPIFDDYL
RCTSVDETLL VNNGFNYNGE KSTFFNKKLQ TVNSDSENVL VKADDNDSEE EMPNPQSVLR
RIASFVGSLG CYVNFSLALI AMIHFFVLKM NRFLIDSADV GSLLRWGQGS HLEFICPFPD
MKFEIALDTL LPRLCDLALS AGDRPLKVAA CEALHACVLF LLGNESFRTV KMKDRESISK
AYSHLFPVLL KLACDVDEVP KQMFSTLFVQ ILHLFSGTDF ANKMVTSCLL DTLMDGLCCF
WNSSLRDQSA YYISEYCRWS MRKVDSGGQN MRSESKVELL VQTIITFAVH SSAVKRAGAA
VAFNNLYKII REKRWLVDIY ILEMFFTFMK SLYLAENDDE LYGTVDECKQ AIKHIRRIIL
HNLDMLQIHN VQRRTPNEWS QSTVHCCCDW LLNTMTWSNY QFRSECFISY QELTDAGSEI
EKLHFLRHIG TSIFGFIDHF ERSHRSVLGS FSICNLQDRV IKGTSIYALV LWLETYEAMI
DGYVWALNTN RISMEAWNDY LLNEDPRVKS LLFPCSLDLV NSIVIGRHFP NLSKAQRNRL
NKTRCKSFVA LCKLIAALIS CQNLNNYQGF LKLLLYPNTW NAFLKVACDP KSLGFRLYSK
QFFECISQDV RLLFLALKNN TFLVQQVSTS MKEYLTQFYP WPDVESVVTC DSHLAIEQQQ
LLNVYGMLVE VGLQSVVELP RAEFLWTTVA DVYFSKRIGL PPSKLGMVKQ IFRVAALTGS
AVDVLIKLLM NTESVRLAEC TSLCSTKGEL LIANFSDEIA LILCTNAELF LKHLKEASRC
QPDVVGRALF HTVSVVVHSS DLRKKYGREL ALQILQIFGQ ELLYWADVVV SNETLKMLWL
KLMMKLILID SKITEWPEFA PMASAYFMLL NDQSLTLDFK NRMLSLLAGF CTFDRHACEL
GRSLKLFMVN NFPLKSDEFA KGTAKYDQYV AACQKILFAF GCTGSPIILE LLLSMVCREQ
SHPIASDLKH QLQKFSSRAN SAVLENILEL LDKMFFNPSS CVCPSLRLAL LNEFFIPFLH
SLKNDLLLTW TCRKIQTLVS CLTESLTLEI QTDCEQQLIT KIGCYKICAI IYNELDLECL
KNEVNVSYLG SDSQMKNELI KKLVSCAVGA KKEFCRDSKL DSIQKHFFEY RCAAQNCVIA
LVKKTQSHLK HYEGFIFNDC WESIIDKEVK YEFDREIQEE EQSAGKMYYS RQDRPSSAEY
ENQVELSVLL DSSLSVMATQ FDFTESLEAR THCAETRTES ANDKDVMKFY SKTKLDLLDQ
HPCMQAMVNV INYMDHMGMI PYEAGTPLPA WMASMRDFLN FGSINVRLFI ARIIVQCFHV
FRPFYLEWIS PIIKLIVMDE FGSNILHYFR VDLIVVLFEW TAHLKEDEAI PKDSLNDLLK
FCVKHCWSKS GKVFKRNLRI IETMLVLWKS FVTLDPSYCL LILEKICFPL GNENENVCGI
SILCLCLNTV PETFSFLTDP NYESGIFSHL VRLLSLKNVK LFKLAAFVCG LSLKVLNELQ
TDCEWLLKNM KAVMSRMTGT MLGRSKCLFC LHEILPNYPE FALQFCNDLL DWFPSLHGDL
KTACLEGFFA VSKYKGDFFE ELKSRGFLKV FSLRYERDQM LGMYIVKNLH ANLTVENISD
LVSSFSSVIG NFSPSCRRAF AEMCCSLYTK LSSLNDSSEN SKAALATTKM HLLTMLSDSN
KSIRQLVYNF WCDASRLEIS TSARLLNCLS QLYTCATEST FLSHASYVML ELTCHSPDYT
RLIYDHPLED CTFENLPIST HWQSRYASLE VPAYMQTDMH SEVSKFISRK RKMPYGRRTY
STESTAWPGF TPTAITDLKK NVGNISADTF ELDLDESDSS DNLTVILDKI LQDIKKPKSS
RVKKVDDLDG DLQFLKNRIL KDTEEKAFFV NLNRKRQKVI ERLKQQSLDL RGKYRRGDFP
DIQIPYSAVI ITLQAVAELD RVFAGALFES LMCGVAANVI EIYNFEMTEK YFDSISDGLR
DIFRSMVTFH RPLVSCLMNF LYNFIEYVHF EPTDIANVAI GSGQPDCGIV LLERRIEVGF
VDISAVTCQE KRLKQVNETD RLWVELARLY KQCGELENLK AVFTKHLLTT EKTKLALEME
AAGDFEGAAT IYGETFSNKQ SKSGDIVEKA ESNLLYEARI RCLEMLNDWK GLETWSTTFS
ASGKTAKLNQ IWETDYLINM HLPVFLRSKL KIALTSDSAA LEELSAFVEQ NQTVPKNREI
LENRHSGLLV LLNILREDFT KSQYFLNVAI DSFLKCYPTL RVCDVTARLK LVQDLLPVSE
TAKFLHLLHA SEHLKLESVV RLCRFWLRYG LDVETTLTTT ADDVVLNRKT FLEIFGKGLV
NSGISVSDVR QSLLPFRLQF GYQYLKCAVR QNNHGLLQRL QDKHLLLEAS NYETWALLQL
ANCANAVKSR TAYLMQALNL FDLKRISDPE VNVTEGSSAD QFALIGMLFD NVAETVVASS
ENTLAEFCLS RWISKTDTAD ISELVTMCYG QAFRYLKLSC QYSSQLNIES PKLTEPLMEL
SSFCDRILRK NGHTSLVNSE CACVMVRSIL KSMKNGSHLA RQLFPRLLSV MEKYPESELE
FQAEIDSVPS WMFLSWMNQM LSALKRSNKF YSILERIADD YPQALIYPLL MLKSATGDVG
ETDFYRLQLK LRKTKIVKEF IDALNLLSHP DIVFKAISLL LLQHAIDELE SIILNISNNS
NEARKEAIAK VYSFVTFADI RRDFLGSFWK CYFKKYLPKM QEIFSVDLCA FDNKAAENYL
RLCSSFLSEL RTFYIPECCP NNLNEYSPWL AGYRPHPMDV FLEIPGQYSG DRRPFPERHV
HIIGFASDIE IMRSLKKPKK ICIQGDDGRD YKYLVKAGED LRQDERVQQL FDLMNGILQK
QHQCSRLKAR IRTYRIVPLS IKLGLIEFLP NVVPLQQFFM EESLRKQYQT IAMEMFTEGP
EKILLKAAGE GSSPLNHLTY WRSFQNITPE TAARCFTEVL KKIPDHLLRD QLLNCCVSPD
VFCFLRQKFT VSLASMCIAN YLLEIGDRHL GNIVLDTKTG EVIGIDFGYA FGASLQYLPI
PELMPFRLTK QFVGVVDPVG MHGLLESTMK YCLKAFRDSS YILLNTMDTF VKEPSLNWIV
EARRQIGEGR TLWNDEANLR DSFKWYPEEK ISAAARKLRG DNPVIIMQDE LMNSRRHLSS
FPLHQIINCI YGKKDFSALS EEDQSAPRGY PLQALTVEQQ TSCLIEMATD SVILSRTWFG
WEAWI
//
