ID A0A0V0XK03_TRIPS Unreviewed; 969 AA.
AC A0A0V0XK03;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=4a-hydroxytetrahydrobiopterin dehydratase {ECO:0000256|ARBA:ARBA00013252};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase {ECO:0000256|ARBA:ARBA00030497};
DE Flags: Fragment;
GN Name=pcbd-1 {ECO:0000313|EMBL:KRX88337.1};
GN ORFNames=T4E_9113 {ECO:0000313|EMBL:KRX88337.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX88337.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX88337.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX88337.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX88337.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDU01000240; KRX88337.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0XK03; -.
DR STRING; 6337.A0A0V0XK03; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR CDD; cd00914; PCD_DCoH_subfamily_b; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR HAMAP; MF_00434; Pterin_4_alpha; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR PANTHER; PTHR12599:SF0; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..969
FT /note="4a-hydroxytetrahydrobiopterin dehydratase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006872699"
FT DOMAIN 148..192
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 212..308
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX88337.1"
SQ SEQUENCE 969 AA; 107658 MW; 11FE559B6CC9A2B5 CRC64;
IIIILLLLVA FIGTFHTGAA QFQVWGQGTP NSALPNQQPN HGDPSIRGFG STIAPKLAIT
LDLLPIGRAM HLQRISWRTP FSTPLYCVSD QSAVRPVFSC LDCSSTEFDN LLHAKSLDKS
TVAEFAATWL DTVPINGSLH GKRLACTPTI VDEKYHAALN GNKFFSNFPS TLHCKAVGNP
PPTQFSWFIE GSRMFDGPMI ALGVDHRLKT YPQLSGHNFQ SIKTSSVFEP GSNRARMGQQ
ITLLCKATGY PIPKMFWYHK TADGTIKNAT CEQTASPANG HTSADEIVSA CSISLDTYFK
SGFYWCAACI AKSANDWACN RNQGTNDGIQ VDIVGPPLVY YEPVTEEKVD ANEARIIAQF
CSDPAPNAND GLQWTIDGQR LLPGERLGSF TAEMPHRNST YSACYNAGLV ISPLTESDKK
KFVEYRIQNE YGDLKKAINL AALIGNGNSS AYSEGDIGLA VGLAVAVLIT KLNKLNIVPE
VMRQAPKPER LPPVSAPHND LYKPEVTYSW RNAGGGGVGG RPQLLIPPKT SSPIVYPTQH
PGSQTREGLN YAELDLVKDA AARRPITTSN LPVEYSRLQP YKPPTSTCSM RLLKLGANPF
CAKAFPFSSS STVCRKMPLS LLNDQEREQH LNELIGQGWK LQDNRDAIQK LFTFGDFNEA
FGFMTQIALK AEKMNHHPEW FNVYNKVDIT LSTHDCSGLS MKDITLGKFI ESVAALKSSF
SLGDLCSELT KYDEYANLKV AAVLNCLREN PYHFSIRESK EKGLLICWSG LDVEDNGECE
SAFSAFKEKT LAEYEATGDL ASENFEMFFE TIIIFIFRER DKIPISLQEI YCVKNLLKRS
HILFELDGIF YQQEDCLTRL LFYEAACSAS FITEEVKCKL HMESQSSMMK FLCTHSWLFQ
VAYNKDDGSE YIFCLRKLPS VDEILLHAAR MKAITIRELV TKLEEQEATD SKVLSVQKYD
GTSAELPKE
//
