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Database: UniProt
Entry: A0A0V0XME9_TRIPS
LinkDB: A0A0V0XME9_TRIPS
Original site: A0A0V0XME9_TRIPS 
ID   A0A0V0XME9_TRIPS        Unreviewed;      1494 AA.
AC   A0A0V0XME9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   31-JUL-2019, entry version 15.
DE   SubName: Full=Replication factor C subunit 1 {ECO:0000313|EMBL:KRX89061.1};
DE   Flags: Fragment;
GN   Name=Rfc1 {ECO:0000313|EMBL:KRX89061.1};
GN   ORFNames=T4E_3160 {ECO:0000313|EMBL:KRX89061.1};
OS   Trichinella pseudospiralis (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX89061.1, ECO:0000313|Proteomes:UP000054815};
RN   [1] {ECO:0000313|EMBL:KRX89061.1, ECO:0000313|Proteomes:UP000054815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS141 {ECO:0000313|EMBL:KRX89061.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX89061.1}.
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DR   EMBL; JYDU01000211; KRX89061.1; -; Genomic_DNA.
DR   Proteomes; UP000054815; Unassembled WGS sequence.
DR   GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:InterPro.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012178; RFC1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   Pfam; PF08519; RFC1; 1.
DR   PIRSF; PIRSF036578; RFC1; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054815};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1494       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006872658.
FT   TRANSMEM    253    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    340       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    411    429       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      783    862       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   REGION      507    602       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      615    762       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      868    888       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1426   1494       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    511    528       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    537    586       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    615    636       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    647    661       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    662    712       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    713    740       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    741    756       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    868    882       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1426   1462       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1470   1485       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KRX89061.1}.
SQ   SEQUENCE   1494 AA;  168132 MW;  E500CF9CA1A0F8D7 CRC64;
     LNIPQEGMLG GVGGAVWMVL LCCACAQVEN NRFADDFSTL ESCANDSTII DLLLKSNLYN
     KHRVPDPNGV VVMVEFWVQE ISSVSELTSD FEMDIYVNEI WMDKALRFDA MNPCKQNITL
     SHHVFDKIWT PNSCFINSKM ASIHDSPFRN IYLTVYSNGT VWTNYRVKVR GPCSMDLSSF
     PLDMQKCTLI YQSFNYNSDE VKMRWGEGKV FQMKQFSLPD FDLVNISTRV EIHISPAGVW
     DELYVTFTFQ RRYVWYVLQA YIPTYLTIFI SWVSFTLGPY AIPARTMLGV NSLLAMIMMF
     GNIMRNLPRV SYVKAIDVWM LACMTFNFCS LLELAVIGYL TKNASPNELP NRRQTDDTKQ
     SCPRTTRSGF LMRHPWRQAG GAGPTRAYCF QKCWSLLGPV YMAERIDRAS CFAFPALFSL
     FNIAYWSYYM NSAKPREADA VKKMNMTAYS VYDMKSNKLL RATKKISQNC LLEKILHLDL
     SKKVKTTKEK LAKAGLLSGI KLSGSEEPLP SKISSRKKNS KNEKATKVTE IVDQQSSRKV
     RGSKKRAIIE SDESQFEDSP KKVQVEPSKK KKSKRLESEE KNESLKPIAV SDYFSQSSQR
     HSEAFSKVLD EAMADFDSPD ASGPRKKGRK KATTPDVDEI LAGAQPINVV GTSTKASKSK
     RSAVESQSKE KKKIPTDNKK TIDSNDGKKA ATKKKSVQLT ETVERKGKAN DGKSTTTNKS
     CSPKTPPKKV KQTSKPATPS SSAEKRKEKD ENEKLSGRPS FGYQRFLQRE GPRALGTREI
     PKGAENCFQG LTFVLSGILE TVDREDVKLL IQKYGGRVTG AVSKKTDYLV AGRDCGETKT
     KKAKELRVSI LDEDGFFDLL SKLPSKSGDG SLTTTVSPES KISGTPKKKA KVIGEMSSDV
     KLDTTTGDGQ AVMWVDKYKP KSIKQVIGQH GPKSCLNKLL NWLRHWKDYH GDGQRKKSVD
     KRSYSHATDD GAQFKAALLS GPPGIGKTTT AQLCCQELGI PYLELNASDS RNKKLIEEHF
     SESVKSRSID QYFRNDRTAE QQQSSNTSDH VLIMDEVDGM SGNEDRAGVQ ELIDLIKRTR
     VPIICICNDR QSQKLRTLAN YCFDLRFHRP QTLQIRSALM TVAYKEGLKI QPQALDQLIE
     GANHDIRQVL HHLSLLAAQN RGIDFDQARQ AALQSKKDTT QNIFESTRLL FKHSDDSQKI
     NFDDRMELFF TDYSAVPLFV QENYLNCVPK DAIDPRQKME LISDAAELIA LGDIVDRQIR
     SLSNWSLLTV QGMFSTAIPC ELLKGFIQGQ IAFPAWFGKN SKFAKLKRIL QQLTAHMTLH
     ISATSDDLNV DYLPRLRSAV VKLLVDNDAK GAVEQCQAYD LTREDVEAMM ELGIWPNRPD
     PMSSVASKSK AAFTRAFNSS NHLLPYSNDA ATVGKRKKMF DSIQEEAEDP FDNGEKNRVK
     NLSSDSEDEE DASVEMFRVT KQKKDHHQVR GKNKVNDEDA KPVKSSKPRK AKKS
//
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