ID A0A0V0XQP7_TRIPS Unreviewed; 1351 AA.
AC A0A0V0XQP7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Prolow-density lipoprotein receptor-related protein 1 {ECO:0000313|EMBL:KRX90206.1};
GN Name=notch1a {ECO:0000313|EMBL:KRX90206.1};
GN ORFNames=T4E_10563 {ECO:0000313|EMBL:KRX90206.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX90206.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX90206.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX90206.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX90206.1}.
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DR EMBL; JYDU01000173; KRX90206.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 11.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 11.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 10.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00192; LDLa; 11.
DR SMART; SM00135; LY; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 11.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 11.
DR PROSITE; PS51120; LDLRB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KRX90206.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRX90206.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1280..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1316..1341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 627..669
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 670..714
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 866..902
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 933..974
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 976..1012
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1042..1074
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1077..1114
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1115..1150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1151..1187
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1228..1263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 141..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 181..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 201..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 220..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 260..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 348..363
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 406..418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 413..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 448..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 460..475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 870..880
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 892..901
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 964..973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 980..990
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1002..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1046..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1081..1091
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1085..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1104..1113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1119..1129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1140..1149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1155..1165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1177..1186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1232..1242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1253..1262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1351 AA; 150196 MW; FEC82CA47E2580FA CRC64;
MCIRDRPYTC DCPNGFQKQG DNNCAADCQP SHFICTKTFK CIPSWWRCDG QDDCGDGQDE
LYFAPNACPA FHCLPGQYAC ADGSTCLSAN RLCDGKIDCP DGGDEGKGSL TTINCTTYDC
VVPGQWKCYK SSICIAEQSF CDGLIDCPNG EDESNCTVKV CSAGYYQCPL SRICIPYLAV
CDGQKDCKNG EDELNCRNQT CSSDEFRCPE GRCIPKSWRC DGEKECLHGE DELNCSSGSC
GSNSFSCKGD GRCIPKSWYC DGYPDCADYS DELNCTRRGV VVCGLHEWTC HDGRQCIMQS
LLCDGERDCD DGSDETAAAG CLPGFVTCRS TQFACKNGMQ CIPKIWKCDG EADCSDKSDE
IECDGTCNRT EFQCRQSNQC IRSGWICDGQ RDCIDGSDED SSLCGCPPSY RKCADGMCYP
AHLHCDGVQH CKDGSDEPRP SCDCPFRCRN GRCIAKRYRC DFFDHCGDMS DELNCETDRC
SAFGLCSQKC ELSKNGRGAK CYCARGYSVD GNNPNRCRAD GSLPALLVVA NEEIRSIDPY
TKFHYDRIVM PNSRVSSFDY RIMPAEVDGA FSSVSIYWTD AHNGTVSRKQ IVEPGRVVRR
EVFGSAAEVL LQGLKHPVGL ALDWLHEHIY WTDLSAKMIN IASLDGSVSI ALIRKNLAMP
YSLAISTTYR LLFWTDTGRQ RARIESAALD GTGRRTLVAN NLYYPTGLSV DEPNERLYWA
DPKTSSIETV QLDGRHRHLV RSFEYTEDKP WFISVFEDVV YFSTYLDSKV KMISKYGNES
VQTLLEHDQI FHSGALVVFH PSKQLLSVDD EKIVCKTAKP CPPGALCVTL DRVGRAFTCL
CPNDMFFDRG TGRCDFEYQE VNNATQTDDC TLRCLNDGKC VLNVNREQIC HCKSGYSGDR
CQNDLCYMRC LNNGECRIFE PFGPICLCPA EYDGNRCERY KCTGLCEHGT CFVDKITGNP
SCRCMSGWTG EKCDVRVDIC NDYCFNNGKC QIQWNHQPIC FCTPPYHGDR CRHCGSLQCF
NGGHCAQNRC QCKPGYSGTD CGQDLCDDFC KNGGECLRNE STPRCICPTW FAGDRCMENR
CDGYCKNGGT CKASDVDSSL YCVCPTAYTG KLCETPLTCE QYCYNGGTCF KEGDDLFCKC
ARGYFGERCA TALPCHRYCA NNASCSLSAQ GIPSCQCTRG LTGTNCMQFY AKSCEEVNCH
HGYCKQHSDD VNRITCACKP GWFGIVCNLP TCHLFCLNGG TCRMLPQEAV CSCPPGTGGN
RCEYKLFDLA TSYAAQRRHV VTTAVVVSLF LIFLLGSFSG FVLFFRNNRY DVGYTVMGAV
VSILISDCEI YLVYFVHILL LQTVSISRKL L
//
