ID A0A0V0XX66_TRIPS Unreviewed; 1056 AA.
AC A0A0V0XX66;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A4 {ECO:0000313|EMBL:KRX92567.1};
GN ORFNames=T4E_2133 {ECO:0000313|EMBL:KRX92567.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX92567.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX92567.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX92567.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX92567.1}.
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DR EMBL; JYDU01000108; KRX92567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0XX66; -.
DR STRING; 6337.A0A0V0XX66; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 586..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 704..725
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 737..757
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 789..807
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 819..842
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 950..967
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 979..997
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 189..427
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 469..956
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
SQ SEQUENCE 1056 AA; 118857 MW; BA8705B6C62DD994 CRC64;
MPNALNTMAS HLRKYDQLTC RLVCAADLTE ILEFEIVNKL PICCSSKDVL HKSVELQSLS
SFIFSRSHSL LKNRQDQTSR TETMSHFVRK ISASIVGTAP RKDTAKNMAG DFLVDPFYSG
QTVHAGYSGR ILAERIRSMI ESEDLHEKTL QSHPLFCEML VLKEDFENDS SEKYSWNEKS
RWIKYEERVE EGERWSKPHI SLLEMENLLQ LKSCLKNCNS CLNAQVESYP DLVEVIIESW
SKQSDIPKNE LKICRSILLA KKHHLRKQKL RIGDITSGES ILGLLDHQAD GGENSKSSTK
PATPPPPKAA QYNLLRKIPK DTEGASILIG YVKGISKPMA HFTRLAKGVI LNEMFEIPIQ
LRFIFVLLLP TNHTEQCAQS IGTCLGALFA DEIFSKVCYK AQDCKDLAYA VDEFTVQSII
LPAGKWNLSI RLEPPEGGNL LQRTVGRPKG PSDFSLDENK EKKLKRTGRI FGGLIEDGRR
KAPWFISDFT DAFKGRVTQT IAAAIFLFFA NISKIITFGG VMDHVLEKEI GTIENILAGG
ICGVIYAIFS GQPICVLSAT GPCLVFETIL HSLCKNQGWN FLCVRFWVGA WTAVFLLIFV
ALDASVMVSW ITRFTEEAFA TLISLIFLVK AVEELFAIVA EYPVLPELKM FLNDTISNET
NGMIFVNRDI ALTFPEEIFN HTIAECLKAG HSYQNGECIM RPQVFLFSIV LFFATFAIAF
ALKWFRHSGI FSSWTRNIIA DFNVTISVAL MTLTNWYSGL NAPCLHVPDR FIPTTNRSWF
INPLHVDPWW IGLAAGFPAL LFSLLILMDQ NITSKGFGYH LDLFVIAFLM LICAGMGIPF
YVAATVISLM HMESLRIVSE IAAPGEKPAI LGIKEQRVTA VIAHLLIGFS IFLTPLMKLI
PIPALLGIFL YMGIVSLIGQ QFIQRILIVF MPTKHQPDYP WLRMVPLRRI HLFTAIQVVS
FVLLAIVEEV KLISMVFPMM LVVLICIRKF FLGWLFTDKE LKYLDDELPS WNEVMRPTRT
NSCVQNNAES IIIANQKGED IQLLPPSPAL AAEVHT
//
