ID A0A0V0Y3F3_TRIPS Unreviewed; 636 AA.
AC A0A0V0Y3F3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
DE Flags: Fragment;
GN Name=USP46 {ECO:0000313|EMBL:KRX94297.1};
GN ORFNames=T4E_6713 {ECO:0000313|EMBL:KRX94297.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX94297.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX94297.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX94297.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707,
CC ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX94297.1}.
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DR EMBL; JYDU01000074; KRX94297.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0Y3F3; -.
DR STRING; 6337.A0A0V0Y3F3; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF733; RE52890P; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00167; FGF; 1.
DR Pfam; PF00443; UCH; 2.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025, ECO:0000313|EMBL:KRX94297.1};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT DOMAIN 309..634
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 384..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX94297.1"
SQ SEQUENCE 636 AA; 73874 MW; 31E438E983CC564C CRC64;
LPLSWFGYRT MPFWVLNGHS EQQPRESADD CRYLLRQIIK LSVVFYIAVR WEVTLCDAGN
IPSLRDCMFA LSALLALSVK IQSHGLLPMS MTVCLAGTCF LNKINIKMNS IQIAEEIPLQ
NHVTRLYRLY NRCSGRYLQM YVKAINARGK SKSPLTLLKV ETDCYGGRVR IQSKKFRKYL
CFNRKLRVTA RYNGRRENCV FVERISENFY TELESASQKG AFLGFNSRGL FLHPTMRSRE
PHCFQFIKEE QINPIEEFRG IDYGPSRRLR SRAKWKKKNH TQVNFDMGQN ASHLEKETTD
EFPTNDHFYG LVNFGNTCYC NSVIQALYFC RPFREKVLNY KSQMKKADLF DNYMQQDAHE
FLNYLLNTVA DILLEEKRHE KRISGGHKVG SKGTTDTVSH TDGFGDNASS NQTQVKDKLA
EHTWVHDVFQ GTLTNETRCL NCETVSSKDE DFLDLSVDVQ QNTSITHCLR EFSATETLCN
EQKYYCDICC SKQEAQKRMR IKKLPLILAL HLKRFKYVEQ YNRYTKLSYR VLFPLELRLF
NTVQFLLVDI FSSHDAVNPD RMYDLVAVVV HCGSTPNRGH YITVVKSQGF WLLFDDDVVD
KMDHINIEDF FGMAADGSLQ KNSESGYILF YQARDI
//