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Database: UniProt
Entry: A0A0V0Y3F3_TRIPS
LinkDB: A0A0V0Y3F3_TRIPS
Original site: A0A0V0Y3F3_TRIPS 
ID   A0A0V0Y3F3_TRIPS        Unreviewed;       636 AA.
AC   A0A0V0Y3F3;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE            EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
DE   Flags: Fragment;
GN   Name=USP46 {ECO:0000313|EMBL:KRX94297.1};
GN   ORFNames=T4E_6713 {ECO:0000313|EMBL:KRX94297.1};
OS   Trichinella pseudospiralis (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX94297.1, ECO:0000313|Proteomes:UP000054815};
RN   [1] {ECO:0000313|EMBL:KRX94297.1, ECO:0000313|Proteomes:UP000054815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS141 {ECO:0000313|EMBL:KRX94297.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707,
CC         ECO:0000256|RuleBase:RU366025};
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000256|ARBA:ARBA00007936}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|RuleBase:RU366025}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX94297.1}.
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DR   EMBL; JYDU01000074; KRX94297.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0Y3F3; -.
DR   STRING; 6337.A0A0V0Y3F3; -.
DR   Proteomes; UP000054815; Unassembled WGS sequence.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02663; Peptidase_C19G; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006:SF733; RE52890P; 1.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   Pfam; PF00167; FGF; 1.
DR   Pfam; PF00443; UCH; 2.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU366025, ECO:0000313|EMBL:KRX94297.1};
KW   Protease {ECO:0000256|RuleBase:RU366025};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW   Thiol protease {ECO:0000256|RuleBase:RU366025};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT   DOMAIN          309..634
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          384..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRX94297.1"
SQ   SEQUENCE   636 AA;  73874 MW;  31E438E983CC564C CRC64;
     LPLSWFGYRT MPFWVLNGHS EQQPRESADD CRYLLRQIIK LSVVFYIAVR WEVTLCDAGN
     IPSLRDCMFA LSALLALSVK IQSHGLLPMS MTVCLAGTCF LNKINIKMNS IQIAEEIPLQ
     NHVTRLYRLY NRCSGRYLQM YVKAINARGK SKSPLTLLKV ETDCYGGRVR IQSKKFRKYL
     CFNRKLRVTA RYNGRRENCV FVERISENFY TELESASQKG AFLGFNSRGL FLHPTMRSRE
     PHCFQFIKEE QINPIEEFRG IDYGPSRRLR SRAKWKKKNH TQVNFDMGQN ASHLEKETTD
     EFPTNDHFYG LVNFGNTCYC NSVIQALYFC RPFREKVLNY KSQMKKADLF DNYMQQDAHE
     FLNYLLNTVA DILLEEKRHE KRISGGHKVG SKGTTDTVSH TDGFGDNASS NQTQVKDKLA
     EHTWVHDVFQ GTLTNETRCL NCETVSSKDE DFLDLSVDVQ QNTSITHCLR EFSATETLCN
     EQKYYCDICC SKQEAQKRMR IKKLPLILAL HLKRFKYVEQ YNRYTKLSYR VLFPLELRLF
     NTVQFLLVDI FSSHDAVNPD RMYDLVAVVV HCGSTPNRGH YITVVKSQGF WLLFDDDVVD
     KMDHINIEDF FGMAADGSLQ KNSESGYILF YQARDI
//
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