ID A0A0V0Y708_TRIPS Unreviewed; 1932 AA.
AC A0A0V0Y708;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Voltage-dependent calcium channel type A subunit alpha-1 {ECO:0000313|EMBL:KRX96013.1};
DE Flags: Fragment;
GN Name=cac {ECO:0000313|EMBL:KRX96013.1};
GN ORFNames=T4E_7550 {ECO:0000313|EMBL:KRX96013.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX96013.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX96013.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX96013.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX96013.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDU01000048; KRX96013.1; -; Genomic_DNA.
DR STRING; 6337.A0A0V0Y708; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 46..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 910..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1135..1155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1314..1338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1354..1389
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 663..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1908..1932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 296
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 601
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 995
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX96013.1"
SQ SEQUENCE 1932 AA; 220874 MW; 1517C39E4137A731 CRC64;
DKSSQARRIP GKRGDGKGPT SLFIFTENNF VRRYARTIIE WGPFEYFILM TIIANCIVLA
LDQHLPHNDK MPLSLKLEAT EPYFMGIFTI ECLLKIIAFG FVMHKGSYLR SGWNILDFIV
VMSGVISMLP FTTSGVDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSILCAM APLLQIGLLV
LFAIVIFAII GLEFYSGAFH STCYNEEGIY FFIFIFSFFE YAQLIYIVHI IFNFSGIPVA
IGNKPFPCTN KSTTGAYHCP EGTTCKEQWI GPNYGITSFD NIAFAMLTVF QCITMEGWTN
VMYYVRTNDS QGDTFNWLYF IPLIILGSFF MLNLVLGVLM NLPKNNEERT TEEERKAIME
ARHLAVSKQL KHLVQQSTET EDDLEEDLDV EFRTKDLSQT GKCWLVVRRL RVFVRRFVKT
QFFYWLVITL VFLNTVCVSI EHYGQPQWLD EFLYYAEWTF LGIFLFEMLF KMFGLGIGTY
FQSSFNIFDF VVITGSLFEV IWEELKGGSF GISVLRALRL LRIFKVTKYW TSLRNLVVSL
MNSMRSIISL LFLLFLFILI FALLGMQLFG GEFNFPEGRP STHFDTFPVA LITVFQILTG
EDWNEVMYLA IESQNGIYGG GMIYSIYFII LVLFGNYTLL NVFLAIAVDN LANAQELTAA
EEAHEQEVQS TYSSADTKND ECEYENGPKM IENLSQNGQA KLTDACDAVC DVKNALNIQE
NKTVTSAPLC YVNSVDESDS NCAFGGHREI VPYSSLFIFS PKNRFRLFVH KIVCTKYFEM
AIMVVISLSS ISLAAEDPVD ESNPRNKYLN YLDYAFTAVF TVEMILKVID MGVIIHPGSY
CRDLWNIMDA TVVICALVGF AFVDSTKAGK NLSTIKSLRV LRVLRPLKTI KRIPKLKAVF
DCVVNSLKNV FNILIVFILF QFIFAVIAVQ LFKGKFFYCT DRTKRFEQDC QGYFFHYDKQ
GSPPQVVQRE WTSFALNYDN TIHAMLTLFT VTTGEGWPGI RQASIDATEE NQGPIPFNHI
EVALFYVVYF IVFPFFFVNI FVALIIITFQ EQGEAELAEG DLDKNQKQCI DFALNARPVC
RYIPEDKDSI KYHIWKMVVS TPFEYFIMAM ICLNTIILMM SYYQEPPAYR AVLRYLNSTL
TAVFTVEAIL KILAFGVRNY FKDGWNIFDF ITVIGSITDA LVTEFGGNFV SLGFLRLFRA
ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIGMLFFI YAIVGMQVFG NIELNGDTEI
NRHNNFQTFF NSIILLFRCA TGEAWQEVTL ACIANRKCDP RTGKLNSECG TNFAYVYFTS
FVFLSSFLML NLFVAVIMDN FDYLTRDSSI LGPHHLDEFV RVWAEYDPEA TGRIHYTDMY
EMLRNIPPPV GFGRKCPYRL AYKHLIRMNM PVDEDGTVQF TTTLFALIRE SLSIKMRSAD
EMDRADMELR KTLKKLWPIH AKKNLTDLAV PPNSKLCNKK LTVGKIYAGL LLLENFRSKR
CGRVPDRSTF LFGRLVDAAL KEKEKIHSSE ADPSSCTEFF SDSEPARSEI RYGFEHQRRM
LPTAEQPRIF DIPGKWQTHD EMNSPMQSVY APQDEYNNER VRHRRKVLRR QQEDDRVDNF
ASAQEWHNYA RQRIQRCTDS KNKALSERTN FDRYYMTGLA DTKGHHETAG NVLFNQLSPV
LGHSSFSPAF GEKIPSPACY FRQQLPMVWE NPVANKFSEV SHLKAHPMFK SSPELQQCAG
RRRRLAAKTA RTFCTSTIRA PREVENYAEF LQLSDDESCN YSARSAKQTV FDSNLMSPLT
VSPDPAFFSS SSSSSDTSFV NVSCPAQQSV NTPSYANYCQ ISPDNSYIFA GNPTSSGEQQ
VRSSQSSTNA AYKLGGYKAT VHCQPVLKEP NQQRLYYMRS NGSNAEEHRC HSVVHSQPGH
IPLSDSEQED WC
//
