ID A0A0V0Y8T2_TRIPS Unreviewed; 514 AA.
AC A0A0V0Y8T2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=AP-3 complex subunit sigma-2 {ECO:0000313|EMBL:KRX96655.1};
GN Name=MAPRE1 {ECO:0000313|EMBL:KRX96655.1};
GN ORFNames=T4E_6873 {ECO:0000313|EMBL:KRX96655.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX96655.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX96655.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX96655.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX96655.1}.
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DR EMBL; JYDU01000041; KRX96655.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0Y8T2; -.
DR STRING; 6337.A0A0V0Y8T2; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd14834; AP3_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027155; APS3.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF2; ADAPTOR PROTEIN COMPLEX AP-3 SMALL CHAIN SIGMA3; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 325..471
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT REGION 201..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 58415 MW; FA76CC88B84EA690 CRC64;
MSSEESDFYA CAMEKMKESG FYESIQKVIQ AELMRMLIHE KEQVNSVCDE ENKAKLNDVD
CFVRTKCGRL YFDVFCDFLL RFKLFNTTKT LLAELGLNQE SSLLGEKKYE CYNLPGIFAS
ESGMDLLNTI SRSSASNDVH QNSCMDSHCN IGSQFVNSLF PSCSVKRMPQ GMCAIRNGES
RTSKTERRNF DEIYSKLEGL GKIPPSRSSA NVPPEEQIAV DESAPSTASS RPKGEGFSFP
ELKGKVQPEK GNANLAIDHL LKKLSINEAD SDTVEEYGKA SDDSIAKDLE FDKSLNRMRH
IVRVARHWAE YSIFYKMFIV LHSSMIKAIL VFNNHGKPRL LKFYEAYPEE TQQQIVRETF
LLLSKRDDNV CNFLECGSLV GGSEYKLIYR HYATLYFVFC VDSSESELGI LDLIQVFVET
LDRCFENVCE LDLIFHADKV HYILNEIVMG GMVLETNMNE ILTRVNEQDK IEKQEGGIVT
APARAVTAMK NMNLSQQIKD IRLPELPSLS NFKF
//
