ID A0A0V0YB57_TRIPS Unreviewed; 1197 AA.
AC A0A0V0YB57;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FERM domain-containing protein 4A {ECO:0000313|EMBL:KRX97512.1};
GN Name=Frmd4a {ECO:0000313|EMBL:KRX97512.1};
GN ORFNames=T4E_4883 {ECO:0000313|EMBL:KRX97512.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX97512.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX97512.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX97512.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX97512.1}.
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DR EMBL; JYDU01000031; KRX97512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YB57; -.
DR STRING; 6337.A0A0V0YB57; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17103; FERM_F1_FRMD4; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079:SF2; FERM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1164..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..355
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1017..1106
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
FT REGION 625..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..568
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 629..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1197 AA; 134846 MW; 24961740C28F5928 CRC64;
MTSMKKMTEG RRTQVVLLDD RRLEIVVQTR LTVAELMNIV ASHCHLKDPD KQYFGLAFQD
DKQQLFWLHD DRRVLDHEFP KKLAPSSAVL TLHHLVKFYV DSFMRFANAA SVELLFLQVR
NQIYRNVINA DHDTIFQLGA LLVQAYYGDF RNENATRNAI KKLPVFPESV LRYYYSPLEC
EDQVIEIHKN LTGMSRGSAV VKYLTLVERI ETYGMHFYEV KDKVGSPFVL GFSSRGIFQF
NSNDKSSALR SFGWNQLENL YYRDKKFSVE VHDPRRVVHV LSSFNPLEDA FQSSTVPGDN
LIAAIGDPTT QVSLSRRTFV PSNVHVLVYL CESPQLCKNI WSLAISQHQF YLDNKAISKK
DKNVQIRHIN ELLDNLNKLP YSAIRMHTDT SNNSTSDLGS SVSSQSLRSL PNMCYADEEQ
ARDSEFYKQL QSRKQALELL LIEKLKELKD VCIQEGNITG EIPSELYSAL APGEAEPKIK
RRVGTSFSIS PDLVNKLVTI DHISKLEADV EIKRKIVAGH EKLVNDPNVS SVVRRRRRQD
LKQAMQQLKQ LENQLEQLCL TATKYNMHCI NYSHSPYKSD KTNSVIRAQA SPFACNSLGR
LQSCRNATSS MVSSSRLSPL RGRDALPYYS QAPSTSASNS RLRSASIPNS PNLGLRCGED
SVPCSSGLLE LNMRQSSSSA VGYRPFVSYQ SKYRQQNYPT LLDRPNVGVG CSRSMSSQSL
QNDEQDVLSP LRLFPKVDAV DHALGSYNVP QQRTSWDQDC LERMNHAVLG SSESVNSGLT
HRCISSSTGA KVAVSGCNGQ FPGMVNYVGS LDRRQLKNRG AGATGLLKRL SEKYTVIGRQ
QQQQQQQQQQ QQQHRQESYA SMDHSPPRYP SRGSATMVAC QSSALETVRP YSNDDYLKYT
NRQPTITPAR RVQHEVNLPP TFSSPQHSAM VHQRTGSKAM IAHDVQDVLS WYDESKPLGV
ARTNASSSDV CISASAANAV TNSAKTAANK KICIFFLCLT LFTEINALRF LVRPGRPVCV
KEEAAKGVVV TGDYSFTEGT AQLSNIVVTD FQNHILFKRQ DFTDLTGKFA FTTDKSDLFE
ICVSTKSQHS GAQAGMLREV ELNIRHGLEA KDYEQIAKAE HLLPVEMELR RLEDLGESLL
QDFAAVNLYE EDIRSTNEST NSRVLYLTLF SVGCLLLLAS WQVLYLRRFF RAKKLID
//
