ID A0A0V0YEL6_TRIPS Unreviewed; 841 AA.
AC A0A0V0YEL6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE Flags: Fragment;
GN Name=UNC5C {ECO:0000313|EMBL:KRX98565.1};
GN ORFNames=T4E_2806 {ECO:0000313|EMBL:KRX98565.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX98565.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX98565.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX98565.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|RuleBase:RU367033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX98565.1}.
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DR EMBL; JYDU01000020; KRX98565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YEL6; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF17217; UPA; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|RuleBase:RU367033, ECO:0000313|EMBL:KRX98565.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Transmembrane {ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 355..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 109..208
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX98565.1"
SQ SEQUENCE 841 AA; 93592 MW; C3EEA1A3E909CE73 CRC64;
LKPILLQAPE DSYIVRGRQP HQQNALLTCK ALYAERIKFK CNGIWIPETE YERREGIDST
SNTPFLQTSI IVNRHSVDRI RSFSGEYSCE CIAYGTGPED KAEQVKSMPA VVRVAYLLKD
FYREPASERR PLNSLVELPC QPPEGDPSPE VFWMKDGVEI ESRKDPNVIV ANDGSLLISS
ARFSDSGNYT CGARNIAHER TTLPATLHIY VDGQWSAWGS WEGVCPTNCK AWINNRRRIS
RLTRYRHCNN PPPANGGSPC SGSSKEQVDC ELPCPVDGNW SEWSRWTDCQ TNCNRVRRRF
CDNPAPRFGG ANCFGPEQQS RNCTDGLCTP GKLHRLSLDA DSMRQQGATL FGNNVAMYAG
LGAALFAFVF AIFFIFGVVL RRRTCHRCAK DYEPAPTQNP TNTIIRATIP AEVSKLTAHT
QLPFIFDTVP TTLNSDRSRQ GLINWSQKSD SSAFYYPNTS DENNYATVDD SRPDYGYYED
EISLASSNGT RCTASPLNGN KVNGCGVLLK NQAVSVFIPE GALIANAEEE QQEERQIEVT
ISVCDERPPL SDDQILLAPV LWLRCNGGVA PLKKPAVVSV EHSALIKVPF DASKDDWQIS
CLISEQIPYE ASMADWNLEA TVGKETLNTD VYCQVDGHCV HFLVEKFGKL ALIGQPSRAD
VNLVKRVRLL AFLHSTCLSI HCVDDTRSAL TRVMRHQREL GGRLCAINAG DALPLKLHAD
LCLSLESISS GWTVTAPVGH YQEIPSSRLC QSFAFDVHCS FSLDSTTSAS QKIFQDNCCP
SSLTAHLVIY QKDDYESAVH LKVDSNSWLN IEDHLRPFQP AVRYNSSFCS ICKFPSRSIS
S
//
