ID A0A0V0YHL1_TRIPS Unreviewed; 711 AA.
AC A0A0V0YHL1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=phosphatidylinositol-3-phosphatase {ECO:0000256|ARBA:ARBA00013038};
DE EC=3.1.3.64 {ECO:0000256|ARBA:ARBA00013038};
DE AltName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
GN Name=Mtmr6 {ECO:0000313|EMBL:KRX99837.1};
GN ORFNames=T4E_7712 {ECO:0000313|EMBL:KRX99837.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX99837.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX99837.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX99837.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX99837.1}.
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DR EMBL; JYDU01000012; KRX99837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YHL1; -.
DR STRING; 6337.A0A0V0YHL1; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054815}.
FT DOMAIN 137..536
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT ACT_SITE 373
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 310..311
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 373..379
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 711 AA; 81854 MW; E395FA89A5A85073 CRC64;
MRPSDIIKIP KCVMGADKAA FSEIAYIKVE NVEWCDCQPD TSQRGTLYIT NTHMIFASED
GKELWISCLQ RAQPVDNGWP LIISGKIFFA LTMIIPKERD CQDIYDSLLA LSRPTCIEDL
PAFCFVPEMK DLMQSEGWNE INMYDDYARL GLPNDNWTIS DLNKNFEVNQ SLNFSFCELE
NNLFEISDIL QYCDGYPERI FVPKNVPTPV LIGSSKFRSR GRLPVLSYLH RTNQACICRC
SQPLAGFSAR CIEDESLMRH IAKTNPHSKT LYIVDTRPKI NAIVNKAAGK GFEDERNYSH
VRYHFFAVEN IHAVRGSLQK MLEVVWNKKN ISVSNFLTGL VNSGWLKHIR SLLETAVFVS
ETVISGTSVV IHCSDGWDRT PQIVSLSCIL LDPFYRTIKG FETLIEKEWL QFGHKFSDRY
GHIYTSDSKE LAPVFTQFLE AVWQLTVQYP LEFEFNEFFL LTLHDHLHSC NFGTFLYNST
KDRIQSKVSS RTYSLWGYMS RLEESLRNPL YDPSDIKDIL KPDLRPQQIK CDSNEYLLDA
LISSRQQILS LKYHIRYLQE QLNQQREASF QQCCLKFSNL LPKNSTDDNN CANDVDKNLE
TFSHPLSAAV SCENKAENEK TVPLIDERCA IALDWASLRR STRCSNRTCN AKFWPLERRV
GVSLLELRTG ILCEMLQFES STPGAWKLRS NGTSLYEMHN EIMLVILNIL Y
//
