ID A0A0V0YI16_TRIPS Unreviewed; 2047 AA.
AC A0A0V0YI16;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Voltage-dependent T-type calcium channel subunit alpha-1I {ECO:0000313|EMBL:KRX99985.1};
GN Name=Cacna1i {ECO:0000313|EMBL:KRX99985.1};
GN ORFNames=T4E_9493 {ECO:0000313|EMBL:KRX99985.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRX99985.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRX99985.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRX99985.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX99985.1}.
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DR EMBL; JYDU01000011; KRX99985.1; -; Genomic_DNA.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF230; CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1404..1427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1512..1531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1612..1635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1700..1721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1733..1751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1830..1849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1922..1944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..436
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 745..1014
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1372..1644
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1698..1951
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 18..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1953..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1635..1679
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1957..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 385
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 963
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1584
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2047 AA; 232090 MW; 2E41D2762CF944AD CRC64;
MWEGPLPAEL RSFRSLSKVS RASIRRKSRS SVAAPPSPTG KFGESSPGHN VDFGRKRSAS
TAASDVPEHN NDHIQHIDDV EDVPYPAYVT TALRCLDQRT PFTWFEKLSM MVILINCVTL
GMYKPCDEDM ELAICNTTRC ITLSVIDHLV FAFFAVEMII KIIAMGFYGP DTYMSDTWNR
LDFFIVIAGC AEYIFKERMG DINLTAIRTV RVLRPLRAIN RIPSMRILVN LLLDTLPMLG
NVLLLCFFVF FIFGIIGVQL WAGLLRNRCL LDLPSSNDSS LELMGLVRYY MPDETSMEYI
CSLEKDNGMH SCNNLQPSTY NGHICNLTID QWHAGNYTLS NSSCINWNQY YTKCGPTSHN
PFQGSVSFDN IGFAWVSIYL VISLEGWSDI MYYVQDAHSF WDWIYFVLLI VIGAFFMINL
CLVVIATQFA DTKRRETERM LAERARYPST STLTTLDQQS DSDGVYRAIV KYIAHLGRRA
KRKAIRYYRE WKKRRANVSE IPSPHLITNS PKPAVSQEAD PSQICLVPKR STYSSPPGDS
LTIPCNSPTG FHSRGSSVSY YSTLEDPGLT IPAADYLPYS PARRYSSHRR SRLVRSARTS
AGSADINKNG RKIKHHRLTS SKRYDPRFAL NYTESAPVCP PSVTGIRLRI HREASTSSNS
LSLDSEDEQT ALYLDDESSN RDEMDLELRK PYTDMDSEFD HDRVRFYTDQ LHLRNKRQNS
SSDLLVKCFA FLKVGIKRFV DSDHFTRGIL VAILINTLSM GVEYHNQPEE LTVILEYSNV
FFTALFSIEM ALKIIADGPF TYVSNGFNLF DGGIVILSIV ELLQGGNGGL SVLRTFRLLR
ILKLVRFMPA LRYQLVVMLR TMDNVTVFFG LLCLFIFIFS ILGMNLFGCK FCKQEMNADG
ELVKSCDRKN FDSLFWATLT VFQMPDGTPC HCKSKIPACK CPRRNFDTII NAAFTVFQIL
TQEDWNVVLF NGMAQTSPWS ALYFIALMTF GNYVLFNLLV AILVEGFQES KAEERRLMQE
EMDKTEIDPS TKAKENMFEV YKSENEKGEK SAITCTCAAG VAAATLLSSR SRDRLLSLPI
MPVYVSGSEL VNAPPPIIQT LPTPVGSPVM SSPSVRNCRK FGSKFDENDD HSNGNSLYLP
NSNAMSNSTI SVKSHPLYKA GFHRDRQIKR KLTGQQSITY LDIPNPKSGS CLRRHWSSSS
STTTFYSCMN TNTESVATSS YKSLESSQQE PVSVSTDAST NNQCNGSVMM QSEVEFSPRK
VSSQLSQQIC SSVNPHIFYP YCRIHGYRLS LIGDGQKKEA LLQSSPLFIH DEINQLNAAL
RQRKKSLKAQ LVARFYQWFQ HSWFQTRMDA SLFIFMPKNK FRAQCVYLSQ QKWFDFCILT
FIGINCITLA MERPGIPPNS FERLFLDISG YIFTVIFALE MFIKVIAKSL VFGDGAYFKN
GWDFMDGTLV LISLSNLIFD LLVKSHAPKI FSVVRVLRLL RALRPLRVIN RAPGVKLVVQ
TLISSLQPIG NIVLICCTFF IIFGILGVQL FKGKMWHCVG PNVAKVVNKT DCLADPHNRW
INHRYNFDNL GQALMSLFVV SSKDGWVSIM YQGIDAVGVD MQPIVNYFEW RMLYFISFLL
LVGFFVLNMF VGVVVENFHR CKEALEKEMK EKEREKKMRK RLQKQLSRQQ LLIKRSKKLP
YWYHYGPVRM YLHGIVTSKY FDLAISAVIG VNVITMAMEF HMMPPELTYA LKVFNYFFTA
IFTLEAILKV FALSIPRYLK DRWNQLDVII VLLSIGGIVL EEMESNILPI NPTIMRVMRM
LRIARVLKLL KMAKGIRSLL DTVMQALPQV GNLGLLFFLL FFIFAALGVE LFGRLECSDE
HPCDGLGEHA HFKNFGMAFL TLFRIATGDN WNGIMKDTLR DDCDNSENCT SNCCVSAIIA
PVYFVVFVLM AQFVLVNVVV AVLMKHLEES SKKMADGSSE AGGSNATDTD EKSCTLRGDS
DDERALHAVS STTSLPTPQD LSKIELPDNP AKFWIPDQSI TQSDTLKKRN DEIDFDRQLD
GLIENIV
//
