ID A0A0V0YMT4_TRIPS Unreviewed; 248 AA.
AC A0A0V0YMT4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Pseudouridylate synthase RPUSD4, mitochondrial {ECO:0000256|ARBA:ARBA00039953};
DE AltName: Full=RNA pseudouridylate synthase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00041563};
DE Flags: Fragment;
GN Name=RPUSD4 {ECO:0000313|EMBL:KRY01618.1};
GN ORFNames=T4E_6431 {ECO:0000313|EMBL:KRY01618.1};
OS Trichinella pseudospiralis (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6337 {ECO:0000313|EMBL:KRY01618.1, ECO:0000313|Proteomes:UP000054815};
RN [1] {ECO:0000313|EMBL:KRY01618.1, ECO:0000313|Proteomes:UP000054815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS141 {ECO:0000313|EMBL:KRY01618.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in mRNA = a pseudouridine in mRNA;
CC Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001166};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00036943};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA;
CC Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001896};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY01618.1}.
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DR EMBL; JYDU01000002; KRY01614.1; -; Genomic_DNA.
DR EMBL; JYDU01000002; KRY01618.1; -; Genomic_DNA.
DR EMBL; JYDU01000002; KRY01619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0YMT4; -.
DR Proteomes; UP000054815; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054815}.
FT DOMAIN 1..164
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY01618.1"
SQ SEQUENCE 248 AA; 28035 MW; 6BB701EB288435D6 CRC64;
LIVLNKPYGL AVTNGPGMFV SLKSILPMLK ELISPKSEIL RPIHRLDRCT TGILMLASSK
FRFLELKDMF KREEIKKTYI CITKLVPNPS SGVIQAALGE RKISGRFKTS PLLINLKGKE
KYLKSGADAK IVKTEYSTLS VGEKCALIKC TTHTGMKHQI RCHMGLCFGC PIVGDHKYSN
FVGNRPQRLP SEVLHKLGIR PSKSRHLPLY LHASEIEIPE FPKQRNLSVK APLPKFFLYT
LKRLRLRV
//
