ID A0A0V0Z6M2_9BILA Unreviewed; 2238 AA.
AC A0A0V0Z6M2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=F09A5.2 {ECO:0000313|EMBL:KRY08215.1};
GN ORFNames=T12_11923 {ECO:0000313|EMBL:KRY08215.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY08215.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY08215.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY08215.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY08215.1}.
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DR EMBL; JYDQ01000353; KRY08215.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF627; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:KRY08215.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transferase {ECO:0000313|EMBL:KRY08215.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1835..1856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1905..2206
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 161..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 658..790
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 870..925
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 961..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 181..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2238 AA; 252209 MW; 92D65D5CD6780123 CRC64;
MIGFISITVM YFYLYAYFWF ANGIYPVSNE SADLQICANS NCSIQLFSSL VVEDLHTDKY
FLKVNDTASV YAIGPKHLWY GNESDHIFPR SLNFTAFLKF IETAIEEDKN LYVVDFHSRQ
VIRSDTARRF FTSEENVAIF RETVHDKDRF EDFLQTTLSN SSTGKSKGIL PNLAEANGDA
LPVDKQRRQV NEESNIQRDD GHSSNADVAK DEHANFSSAR SGPGMEGDDD LKQQQFAASN
FSATSDKAEI GNFSKLNETL SDLSKIVENA KSEMDKNLVK VDSQLKSHPV EDVKSVDKKL
TKNLQKSTVD NLRLPSGDDA VNGGSLFTEE MNKMKDELKL ENNFTDGGGK SSEEGKELNI
SSSYDDDHDS RSGGAADDGK SSDEKKKLGV SSSDDHHDSR SSTVADDGKS SEEGNELNVS
SSDTDHGPES STAAGDGKSS EEGKELNVSS SDDHHDSRSS TVADDGKSSE KEKELSISSS
YDDDHDSRSS SSAAAGGGEI SNYTSVIDDA SDDNDNVKVE ETFPDGFPRE DSWISQTCDK
EEEQCDETNR RPVVGVPEMP ASTDLMTLLI RGVKLYFDQS RRAFASIWSL LFAVDDSSGE
TFFPKATTFG WNDSSLLILT CVSLVVFVVD RLLWKRWQRK VYANDSDYVR LFSKYERLVE
KLEQADDLQE EKSRILAELK CKDAALKGVE AELVRASREL ENARGGVGSE FLEEGRLEAM
EAAIAEKDRQ LQDADRRFVE LREEADKLDR GHEAERQQLN EQIRQLYANL EREKSRNEKL
VEELQSREVE LASTVELKQR EGQLLAELEA SKVEIHGLKE VVQRLWQCRR RSNDQLKGVA
DWNVEEDEEA TGVCEGSEQP TDDVDVGLDL AKLYAQLGRS NGELEKMRAE VEKEQRCRLA
VEAELEQLRC ERDSMKNAQQ QAEMQTMEAV TRLKVLEEFF EARQKEMQKQ LGMQMVISKQ
LEGFEDTANR LKDEKEHTEK MMAELRDEVE VLEKEKRKMQ LQLERAQQDL WLANRKHDRQ
LDALQVENKH LRDRLVQADR LDGSGVSLET TNQSADAEVA AALLGVVPPP DLSLLGSLPE
LPPPDIPPPL MPPLPDLPLP AAVQCGGDGV NGSQPLYACE MARLSGGCRR SKSTNRGEID
VSGSPSPDLP TRMLSSSRGS IRSGRCYDDN DHAQLSPSSS SLRASARYHR PKDTEWSNGS
GGRKNASAAR SGEWRRKIRP PSSGGDGLYS SDRSMETDAS VVSPPKLAVS GVPPKGAVNS
RPVVRLRMIR KNQSFVGGGC CRQRLLLLHL EHGRPLALLR LPSRRSTASK PHPCQENIST
PTVMPFTGHG PFPTCPKRPT RLDHRRLMLT LLWTISLWQQ SWAYPSAFQC RFIFLADCLR
NNDTPNSLQH CQEYCGNYDF DENCLETNFT CWKRLLQSSC NVSETSSSFN TVRHPPLNFE
VNYFSDPFVN PYRLVINWSA VQFAELFVVE YKDMDDIFST FSSQQSQDII NDNQYLVTTN
LSVIFKKPRL CPTYGFRVAA VNYLGMSNFS DVVEISPPIP QPADLSYSVT DKRAFDEPYV
NVEGEESART VVVTVEYKSP PNWHLSDIVG VKSSLFWVDC RIPTNKILLV DQVTPAQNDS
KIFIFLPDFV MTHMCKFMFM LEKLESACQT VFQYPDKNTG DYPGLDFILD CDNVVNSGCK
NPASVINPKC FVDGVSYELV NQDEKLSKSD INITWRLSLE QLQWPILYYA IRLDEVEPDS
SQFTLIYSPK VLRAVALVRT CDDEIDGIPL NCDNSTNNYL VKNIELGTRY TLQVCAVYES
EQVAPIHWNL TTRTELDFTF AAVKSSNVVL KREHVYVLVA SVATLLFAML AIVLLYRRRS
MKKQKSLAEL ANNHHDRPCA TSENPYVAQP RRFDHWELGR SKVEIDFDKR LGSGAFGAVY
KGKIIGRILG NRLSNSVLAE NWTKMEDCDV AIKMLPEYAD ESAKSDFRKE INLMKQVGYH
EKLVNMLGCI TAEEPLCLIV EYCAQGDLLH YLRDRRKYMV QLESKGIDIG NLEDNSDVDL
DMVLCLKDLI SFSWQASVGM EYLSQKGFLH RDVAARNILV DHDKRIKIGD FGLCRYIYSD
MVYMGKGGRL PIKWMALEAI KNYEFTTKSD VWSFGVLLFE IITLGGSPYP GIQPADMEQL
LESGKRMEQP SNCPDELYMT MVNCWQKEPS TRPSFTEIRE RLRAMLEKIT EDYGYMGLSE
NRDYYNVTNA EDTGSNIS
//
