ID A0A0V0ZEA9_9BILA Unreviewed; 1384 AA.
AC A0A0V0ZEA9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7 {ECO:0000256|ARBA:ARBA00017647};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATG12-activating enzyme E1 ATG7 {ECO:0000256|ARBA:ARBA00029897, ECO:0000256|ARBA:ARBA00032823};
DE AltName: Full=Autophagy-related protein 7 {ECO:0000256|ARBA:ARBA00030242};
DE AltName: Full=Ubiquitin-like modifier-activating enzyme atg7 {ECO:0000256|ARBA:ARBA00018730};
DE Flags: Fragment;
GN Name=Y67D2.6 {ECO:0000313|EMBL:KRY10744.1};
GN ORFNames=T12_11626 {ECO:0000313|EMBL:KRY10744.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY10744.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY10744.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY10744.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the ATG7 family.
CC {ECO:0000256|ARBA:ARBA00010931}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY10744.1}.
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DR EMBL; JYDQ01000219; KRY10744.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd17980; DEXHc_DHX35; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR InterPro; IPR006285; Atg7.
DR InterPro; IPR032197; Atg7_N.
DR InterPro; IPR042522; Atg7_N_1.
DR InterPro; IPR042523; Atg7_N_2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR NCBIfam; TIGR01381; E1_like_apg7; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF16420; ATG7_N; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00899; ThiF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Helicase {ECO:0000313|EMBL:KRY10744.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 755..919
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 951..1126
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT ACT_SITE 562
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606285-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY10744.1"
SQ SEQUENCE 1384 AA; 156308 MW; 8D9376DB9EB7D32E CRC64;
LKAMATVETE EVKLLRFDPF KSTFHPAFWN AVTTKKLEEW KLDETPKDVV GYYQNTTRSV
LPSYFSLDFN SLDPVPKVAG NSFVVHGLLY ILNTLEKFAA VDKKELMTDI GKQIWNDIDT
KVWLQNPSLL NRFILLVHID AKKYLYDFMI GFPAFNVSDM FFASEPEQFS KLDVDFMKAI
QRVCLEAQRD LLPYFVILKQ DDEYVLKMLN DPICETVTED KIFLAFADPS ASPKYAGWPL
RNFLKAWKVF RPDFTYVRVI CWRYTSFNSI DQPTNSLLLH ISMQCDKDAI ATFLPVVGWE
KNSEGKVKSV HMDLSAQMDP NKIAQSASKL NLHLMRWRIV PELNLGLHWQ TSCLLFGAGT
LGCNIARCLG AWGFGRITFV DNGRVSYSNP ARQSLYSIKD CIGGRKWKCE AAASALKDIY
PDMEIAGERI TVPMPGHFVD IEGEKEQSFA EDVNRLERLV STHDIIFLLF DTREARWLPT
LLSCLHNKIA ITVALGFDSY LILRHGFGCG KKSATDGSDV HSPLQNVEST TSASGANLAC
YFCCDVTAPG NSTRDRTLDQ QCTVTRPGVS MIASGLACEL VTSLIQHPLQ GQAPVEKPDS
GANRSCLGVI PHQIRGYVNR FDQWNLTVER FASCIACSEP VIDQYKRGGF RFVADVCNDP
TLLETITGLD RLKDDAKDML VIELAERMIR PDEKLLENWK NQTTSSIKSV EDRLLLDEVG
VEVNTGILYN TNLTAFSVQQ QRVRLPIYKN RDVILYLIEK YQTLIIFGET GCGKSTQIPQ
YLLEAGWAEK QKICVSEPRR VAAVTLATRV AEERASILGH EVGYVVRFDD FTQSDKTRIK
FMTDGILVRE IMKDPLLNQF SVVIVDEAHE RNVNTDITLG LLRKIIAKRP ELRLIISSAT
LDAQEFHNFF NINDSDDPSR NTSFILSVEG RTCPVDVFHL KRPIPDYVKA SVITAINIHR
TEPPGGDILI FLTGQDEVVN CCDMLKEESK KLKGYDRLWI VPIYGALPFK EQIKVFDSSP
SGTRKVTVAT NIAEASITIP GVVYVIDCGF VKMRALHPDT GIESLMIVPI SQASAQQRSG
RAGRIRPGKA FRLYPESEFD KLRAFTVPEI QRIHLAPALL QLKALGINNV LRFHYLSRPP
AMSMSRGLEL LLALGAIDED GKLTSPLGVQ MAELPLPPMH AKALLVSGSL HCSEELLSIM
AMLQVQDIFL SPFGSKHKAA GKTQRWCAEH YVNYKGLCRA TEIRAQLFTF LRRFKIPIVR
RLDAVDRIKQ ALVSGFFSCA AKLDHTGTYR TIRENFPLKI SKGSALMYRN QYPKWIIFNE
VMQDSMRDIT AIDPEWLLMN QLDDYGFVII NYQFYEADLA KVSYPSTDMF TDVQIIHDKL
QVLC
//
