ID A0A0V0ZHZ6_9BILA Unreviewed; 3267 AA.
AC A0A0V0ZHZ6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=4-hydroxyphenylpyruvate dioxygenase {ECO:0000313|EMBL:KRY11923.1};
GN Name=hpd {ECO:0000313|EMBL:KRY11923.1};
GN ORFNames=T12_13464 {ECO:0000313|EMBL:KRY11923.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY11923.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY11923.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY11923.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the 4HPPD family.
CC {ECO:0000256|ARBA:ARBA00005877}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY11923.1}.
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DR EMBL; JYDQ01000179; KRY11923.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.40.50.2300; -; 10.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR037523; VOC.
DR NCBIfam; TIGR01263; 4HPPD; 1.
DR PANTHER; PTHR24060:SF172; CELF35-1; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 3.
DR Pfam; PF00903; Glyoxalase; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 4.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Dioxygenase {ECO:0000313|EMBL:KRY11923.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:KRY11923.1};
KW Pyruvate {ECO:0000313|EMBL:KRY11923.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2947..2972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2984..3004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3010..3031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3052..3072
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3105..3123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3135..3154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3166..3184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..164
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT DOMAIN 195..355
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT DOMAIN 2976..3151
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT COILED 1899..1926
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3267 AA; 370700 MW; 9F9EB7D3BA19A064 CRC64;
MAVINFKMLL QQHAWKPLTW LFAMLSLINK YIKSLIKNFH HIKFWVGNAK QAAEAYCVHF
GFQPLAYRGL ETGSRDVVSH AIIFVFESPL KYGNKEMDHH LTLHGDGVKD IALQVDDIEK
TVQTAESNGA DILEHVHEIN DQHGQIRIAS IKTYGDVIHT LIENVSFKGS FMPGFCSPLF
TNPLLSVLPQ PQLNFIDHVV GNQPEKEMEK VVSWYEQTLN LQRFWSIDDT VCHTEYSSLR
SNLITNSDHS VQMAICEPAK GLRGVSQIQE FIDFYGSAGV QHIALHTDDI VFAVSALKQR
GVQFLEAPAT YYENLKARLL QHSTIRIKED LNMLQQLNIL IDYDDNGYLL QIFTKPVQDR
PTLFLEIIQR HNHKGFGVGN FKALFEALEM EQKRRGTLYY DNGPSCGTVS EEGLQIEEIA
QWVIKILNQA SGTVFGLPVT DSFIPGIELG LQVLDTCGIA SRAIRLSAEA FSDLQSPKHK
CTFNDTRISL GVIVKADDST MHHLADFFHQ YKKSVIGLGS RSNMLKQKQL FTVQPDIDTI
VQTILKTAEA MEWKHLWLIY ENTDYGNEGK TLLTNMSAQQ QSICILGTEQ FSHGTNSNGN
IKLILEKILS KKEDSYLIIL FMSRPVALQF LQAAFEEELI ADSRRMKWIM SDGFDGSFVD
IFDLSKGVIA ISDENPYRVP EFLSHWTEAD PKEHSKFWYK EFYQHHDTNP AFYRFGICKN
KKSAINHTDS ELFLTPSAVH VVDAIFTYAI ALKGAWMAKC RGRPGLCPQL VQMDNQDFIR
FIKHVEFSYQ KENRSPPSFI NRQVSHRKPK SQVAVFQVQS DEQANLLLKQ IFRYDRFRNN
RLLQLSAPLY YDNFGKIDME KKHSMTTNDK SRRCMTFQKR KACHIIPGDL YMIAIIGMQE
KGSYFDYCGQ VNVEDSLADI VFFNHALSSL NKKLLPDLKI GSIVVDSCSN AIFAAQQIGT
CLTNMEEIIF SKTENDASIS KQPLFIGALI QADGLESAEI SHLLSLTLPS LPIVMYGKNV
VPGIAPNIIN FGTNFQNIAD AVFNVIQQFP CHYKQFIVAR KYAPSVSVIE SMAMNNSIGN
FKTLLTNFGS NFDGISAMNW IERNANLSVV VLFLEEAELL EFLKTANQSA TSSNHIYLIV
LDHNWTFEKL RNFSHLEGNM IIFLHTDNDA NYSLQDHIIN EAVDGIFNSK NIWIREYIEN
NLNCGKQNEK NEHNAIVASC KNETLLYLKK LALRHSIKTN RLLASVDMLV ATLHHVVKNN
CFDGFAVGSK CSQFLQSFLN LKENKMLNYV TKHYEKISEN DMFVLPTKIG IYFQSQLNIE
KFQQIGTFYF NSNKFEIMDF SLFKNLSNQA SSYCLNGSSE NQYIEQSTVR KSEELLTTVL
PVTDISDYLL QSENIKEMHV FFESTVMNIP PLSTGESVLI GVLLPLTGSA NCGHVDYNKV
KNEDAVYALE ALLWARKKIH ILYNMDIQFI IFNTCSSVSK TNILLNSFLI NPRQFFGEKF
GLNYTEDLVV GFINGYSAGP ASVASEILSE ASIINADIKN NVQNQNSMTL HFSDNLNSYI
SAALQFLEQF QINFISILYS NDEIAVTFTD KFRLKANNYN VCMAYIGQVD STQSLNTHID
NLESVRNAGA TVVLVVLEFQ KLLAFERALE KQSHGLTFFI ISFQNEINAW NSNHFPVLLN
SSILLKRQAD LPKDFMNHLL QLRYDNNDGN YLWSDFVKKK FNCTTECNDR LPDVSDYAML
NADQVLSAVN ALSALVAGVR KLGSTICKNQ TIICKELKEL PNFGSELLRI LQKEPFPAVD
DISRKIRIDE TRQVNEKLTI STTLILGSNE APLLQPIAVY ENEKLTLNRI GTEIKNQPVF
TSQCLDIHQC KQCWKSMDKL LNSYLRKFSP ALEVHTESSD HVEEVLSISE EEAENVEKKT
NKQIEESKSF VCIKSTSNIY LMAVIPIHNR EQKKLTCGAF SSNQYQRWKA IQWSLERLNY
YLLAQNGINL GIIAVDSCSD QAHTIKQLSY LINGDMQLNS CIRGNFSDQV IAAILVPYNQ
EDASHEATVD LLTSNGILTF NWDSSFAYSA NSMLFSTGLI EQSMVNGLVK FLARTKWHYV
AYIYSNNKNS LRRRHIFSSL ANDNGICSEY ILYPSHNKQS CGEMTELFDQ LKKIKLNGLR
GVVLGLSMNK LRCFLDRMER LVASGQFSTN QFTFITALDA NYKQAFFRYE SVAAGFVVVH
PTAVELDEFH QYWKALKHLN VSNDIWWKEL LATDDWPERQ DEKLLYLANA AYSAGHAVYE
TKQQLCGSGM IASKKCNNLI MHHSFRNAFR ENVATSKFVD ESGQMFTFGK DGLATQRVSI
SLLVMDLDIV QWIEIGRIEN DVFDTKQRGN SPFQNYEPML YLQKLTSKCT NTTLCPQCSR
CPSPVQLSTC PSVHCKNEFG KSTTPAQSDV TTEKVNSPAP DMHYSESKLH WIVPSPNGIY
AIALVPVHFP SEELFSCGPL DIFGGFRQAS AFMHSVEKLN KQLPKHDQIG LIIIDTCNAK
SDLAFSWIYH LSTNNRSVQI LAVLDAGYSN SNELAELMKN FQIPLFTIDP KLEMSKNEWN
LQFKFDLIWY AEIACSVIHR LKFITPLVLF EQSNKLHSSI MEKFIYCLES NNFNNVITKI
PVNNYRELNA ILNGLSNRPT AVFVLFMSST FISAFRRAVV QQPYNIGQTI VLGYGLERIF
TTASPIEQVE QQHSNLVTWL SIELLIENEA DTSEFLLSKQ LNNYQPIPQY WFEEYWQQMF
TCKLSNSEIV GNFHFHKNCT ENEQINSTAL SKNLESDMSV WFLMNVMVDG YKTYVDNDCA
QVSTAAQPTR LVNCLKNGNR SNLLKYLKSS RWNQIVVGNE FNNYKTLENC KIVLKKIYMD
KNKLLAESVA LWKQAFTLTI NGKPTSSSAS FSSKDIICKT SSVEEDCWKR FDFAVSNLEE
TNRMNEIWIV IAISLAGLGM TVCIITSIVL VVTDHAANDI FNHLTLFGLF NLYAVTLAFT
WQLSDIVCTI RLYATGFAWT LVFAPLSVKV VQMRLFPENG KKQAYCWKKR NSIMVILAVV
FVHGIGVLQW MIVSKSTKIS VLFKQAKCAP VGSLATFELS LTFSMAYPIL IILATMITAM
TTTTTNMSKY NKSSCGIAVT CMLTIIIWLF WNITSTMEIF QLSDPVIAMG ILINASVLFV
GLRLRDNKNT STQSRRSYNV NMIRNEASLQ PDPALVPYGV NFSKSKLGTF DSDQSYSTYS
TVPKTKRYFN VMAYDGSSEF SATTMVN
//
