ID   A0A0V0ZIB9_9BILA        Unreviewed;       497 AA.
AC   A0A0V0ZIB9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   08-NOV-2023, entry version 13.
DE   SubName: Full=Tyrosine 3-monooxygenase {ECO:0000313|EMBL:KRY12321.1};
GN   Name=MRE11A {ECO:0000313|EMBL:KRY12321.1};
GN   ORFNames=T12_10875 {ECO:0000313|EMBL:KRY12321.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY12321.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY12321.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY12321.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY12321.1}.
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DR   EMBL; JYDQ01000167; KRY12321.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0ZIB9; -.
DR   STRING; 990121.A0A0V0ZIB9; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF15; TYROSINE 3-MONOOXYGENASE; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   PRINTS; PR00372; FYWHYDRXLASE.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KRY12321.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT   DOMAIN          149..495
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         328
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         333
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         373
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   497 AA;  58174 MW;  71494D4D7ACD460E CRC64;
     MTLYIAKIVK RNMPYGGLHG YRSHRRRDSL ICDAVLDKQK RKEKVESYCK TLKELNAPKE
     FLDNFNPELL EWLIKNDADV AEFSVIFSCE NVFKVLSESE HVFQKFHITL KHLETRMNTA
     GLDVLIKCNS NRENLFAAMK ILFQKQLLHS VRIYPPEDKS IPWFPTNLYE LDNCKNVIMK
     INEKSEHQFE GWNDEKYRKR RLQFAELAES YRHGCPIPYV EYTKEEVETW RTVFTSMSSL
     HQKYACKEYL NNFALLKEKA GFGPDAIPQL EDVSRFLQLH SGFRLRPVSG LVSARDFLAC
     LALRVFPCTQ YVRHHSFPHH TVEPDCIHEL LGHVPMLLDP VVANFSQQIG MASLGVSDED
     IEKIATLYWF SIEFGLCKEN NEMKAFGAGL LSSYGELEHA LSFKPQYQPF EPEVTALTKY
     QDEEYQPLYF VTESVEEALR KLEQFSKSLK RSFNVWYNPY VQSLITITKP SDAKEMLDFM
     QQEFSNFLRL REYLFIT
//