ID A0A0V0ZJY8_9BILA Unreviewed; 2618 AA.
AC A0A0V0ZJY8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|EMBL:KRY12880.1};
GN ORFNames=T12_9352 {ECO:0000313|EMBL:KRY12880.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY12880.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY12880.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY12880.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY12880.1}.
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DR EMBL; JYDQ01000154; KRY12880.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRY12880.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1595..2159
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2276..2588
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2586..2618
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2618 AA; 298809 MW; DC8D6EAD9212DBE5 CRC64;
MNEKMEQDGK DDIEVFGEHL NRLLSIYNVE GQKVNRSHTY HLCYLLHFEL LPSRVLKDIQ
NTGDGSYYKT EMRFFTKLIR ERPAVLTNYS KDAEIATTFY SWILMKTLGV FSVYGSVALK
EEIMEMARII FNALGQRYSV SVMERLIVEF CKIQYIRSQA LNKAGTKMTY TFQLGLRSME
VESVGEQYPT FHMTDLEFEI ADNDQCEIFQ CFFCDFITQR ESILISVQSN WLECFLITIL
DQFEDGDFEL KERSLTCLLN IICNEKTVFP PHLGPFFIDH CFAFIEWLAE YWPSSFVNAE
HVCTLLVEVL QFCTAYANGH QRPVGCSILF QKITSKMLTQ FCERLKRIIV NANFASFDAK
LRIRLLEMFT YCLSNLRLFP PVDEEIANRL GCCFEAALDS LISRTLLAEP LEMLLSHLFY
FCDLIWTSES TSCFIFEYYQ KMLDEITKGF AEPATVIEAL STCNFLLRVL FHVEEEQMSS
KFRQALDIFK CEICDRLFSM QDGFAVVVPN LNGLNPDIAA SMFQLLIDTI TLILLAFVNK
MKVHHVTFAT ALLSLPWIDT EDLLDSKCAD VEQFSSMKLI VSRLDLCAIV QKCLHSLSIM
PSTFCPLWRS YIFKSCIMSG RSEYFLYSLK RLSTLLQHLS LDHRRQYFTE IQNLTCSNHF
HGDDQTKLIG AFSECICVMA NACDMNYDEE QKAKCRCCSG EFLKIDHDSF AKYLPTFCPT
RFLFDRISQA KLANEYLALL DLIRVVLVHC NLTENEVFEI YQKTCFLIDF DDLSVRKKYS
ICIGLMTALI DNDEFVESIK SALSRVQTGE FEHSSQSLLY YLGETAKYAR EALYEHAIVR
FTIFTLAQVG GDSLLGLAAE TLKDVCLMRG TTPKRLHVRF GCPIGRHLVR LCCDVLRESH
GDRASSDEVG CILRNAAVLF DYGERQVAQF VQSSVRHLVP WLMIERSNEA SRAHVVVAKL
LGTNRHCLLA CNFRHVVLTI TLNELPNDQV ERVFEFIERE GSVEPAGRKR GFSSVGGGGG
GQRWTVATYL SWDLYSCVNE LLLHLSLNVE RVLRMLLTIV HNFGRPPDVS ASAAEAEVIG
FIKPRILGVL IKFEEKFRSG DPVRDKLVAL NSLDCLMLMC GGQILDQAKL KVLSTLRSAL
AVQDAQFRQL CSRAWHTFFT HLRDDALKDI LLSAVLTMLP LFEYEEQPQA QPDEARQRKS
MDYNESILNF LFEQRAALVG DELDALAFLL LEGEQQCRAP VALLRRLRRP DACADWPLET
ALARCSTLLL GSESADIRRR CLVSLSGVLR RRDVELARRL AGADVVDATV AHLHVALMHC
VRAGDESVRL LAASALGQLG ALDPGRLPAL DRRSEADVPQ PLLYADFSAD YNSRFGATVL
VELAKYMTAA TDGFLYDACS CTIQEVLNFF NCAQDKDTSQ TSAGLLWSIL PTHVQTLISP
LLTTSYRFRA RKNATIDQRP IFGTPFGCNM KIWLQSWISV LVKTIKNETA SRFYKTVAVM
TEYEVGFAHF LLPHVLFQKV IENDFDEVLN EVLKVLHSFN EKNNLEKSFC SAACQVVFSS
TDFLRKWANR ARAWPEKDTE RGYVMNFLNS IPKNLLAECA MFCNAYTRSL MYYEMHLDSS
NANIEEHMPF LQKLYAYLED VDAVKGSLTF RIAHGKPTLH EYILTYESIG NYHDALPYHE
AVTDAYPDDL SNHIAFVQCM LKLNQVTVSL RYIDGLRSEN KEWSERLHLC RAETLRRLQS
WDLLKQEIDE HPSSVGWDAD LGRLMLCVKE RKCDSFQAEM SAVRSRIMDE ISVAMMDFAS
YERIYGSVLK LHQLYEVQQF LEQVGRAGEE DPNTVLTNLG RCWDSRLKLL QHSSNVRHPV
LELRRQLLDF WPRCDETIEM IGSSWLRSAK VARKAGHLQS AWSYLAKVKG KNFDAVFVEE
AKLLWLKNEQ GEALSCLENG ISSRFSKLFI SPNQAEADEH RPLFAKAQLL LANYARDSSS
RDAFEVLDLY KKLLNTCPDN EQGYYNTAVH LDQIAQTPSY RHSYHIVLPK MVSSYGKSLK
YGLKNLHHSM PRLLTLWLDS TARLHQKQTK SKGDRDADVG LSESDNGQKM ELLNSLNKIV
RQLSDELPVQ LFYSCFSQLI SRVCHPADST AEILKTIIAR VIAMFPQQGL WMSLSVATST
NPQRRQACKE VYEKAMALNA RVKPLLEDMT EFLELLKKLC YSAAGARRLS LSMSQDFPKL
NSYFSNRRAS RPPIILPMQS MMDINMSVLK LSNSACSDQK PVGTSFPIQP VYIAGFADTV
EILSSLQKPK KILIVCTDGK TYPMMCKAKD DLRLDKRLME FNNLVNTCLL RNAESRKRQL
RIRTYTVIPL SHDCGLVEWV NNLEGLRHIL GKLYKELGDS MHSRELQSAM ARKTDSLGKK
LEIFETVLLK RHPPVLSRWF GYRFADPTEW YQARTNFVRT AAVMSMVGYV LGLGDRHGEN
ILIDSTTGDV VHVDFNCLFN KGEDLEWPEL VPFRLTHNMI DAMGPLGCEG AFRKCCELTM
QVMRERRGML RSVLETFLHD PLVEWTRNSN KPRPTAGEDK AREHLQNIET RLKGSVKATL
DSAYGLPLSI EGQVAHLIRQ AMDKKLLCQM YIGWAAFM
//
