ID A0A0V0ZLH0_9BILA Unreviewed; 972 AA.
AC A0A0V0ZLH0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=X-ray repair cross-complementing protein 5 {ECO:0000313|EMBL:KRY13155.1};
GN Name=Xrcc5 {ECO:0000313|EMBL:KRY13155.1};
GN ORFNames=T12_8470 {ECO:0000313|EMBL:KRY13155.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY13155.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY13155.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY13155.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY13155.1}.
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DR EMBL; JYDQ01000146; KRY13155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZLH0; -.
DR STRING; 990121.A0A0V0ZLH0; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR019174; NADH_DH_b-subcmplx_su6.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR Pfam; PF09782; NDUF_B6; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 537..677
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 110928 MW; 6B786B43BAF84DB2 CRC64;
MDKGKKPTGS SDEVLNTPAD TATAGKPLKI VSSSSGHGPK KSYGPWELSF TDTPNSFFYR
PPESSSDAPS HIPSNPMNLE LHMKDERSRV VGLTPEEIEW RKKWVLDQKL HPDEPVYVES
AVMHLNPIRR LYRYPWDSLE RKVLIPALGL KKGHFVRIVV PKIFIGMLTS LYIYYHVKYN
KPNWMNRIRS YHHFPRSFIR NQDLIERDYP GLLDKAFPIP KEPKDFYDLN FSRRVTHLDV
GPPTQGCIIA CLNFCVFVEF TVVEYIPAVC TDDKKKAIMK IFSESKDELA LILYNTADSK
NPLSDVDKNK YSNISLMNNF QVSSWELFSS LNSIETTSPA LHSIDFLKVL QVCIHCIDEK
TLNEKFQQKS IVLFSSFDAD IIINKDDMDN VTKAIKQHQL ELAFISCNND LCASNVEEDN
YPKAWKYAKE FITAVDGIYC NLNEALNMLG SFQRRSIRSV PWKCNLEFGT ILQIPICMYL
KCKCYKLNQT WKWAFAENPY VDVKLERAYV RSCDDEDELL LSNEEIISST ASKIWSGIEV
DSSYLVKAFR FGSSVVPLNK FDLNEAKYKD RKKCLKVLGF FDRCMVKQWH FAGDGTHFVF
GDPKSAAACQ AFSALIHSCK SNSKVILVRY AYNVASNPKI GVLIPLLKDT YECFVFVILP
FEEDLVIVDQ KSIGEFEKCH VTDEQLDAVD KLIDAMNMTD LSSSASSSGD GIFKWSKVKN
PYYQNLFRCM TFRALQPKEK LPVLRDDLLE NVQPNVALLD NAKNAFDLMR KNFILEKVEN
AKGKRTAAEV FKNESKLCDA FPAKVASFQA IDEKIVTMKI GTVNPVQDFI EISSQIGKNQ
ISEGKKLFIF CEQMKNVILA FVQESNDDVF YDKALHCCAV LRPVCIKQSL PDLYNTILRQ
AKCELVLGKQ KNFWLLLKNK KDSLGLITVD ECQSSSISQE DVVSFYSEEV SDEIVKNNPQ
LPDSTDLIDE LE
//
