ID A0A0V0ZMT3_9BILA Unreviewed; 1210 AA.
AC A0A0V0ZMT3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN Name=IARS {ECO:0000313|EMBL:KRY13714.1};
GN ORFNames=T12_8267 {ECO:0000313|EMBL:KRY13714.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY13714.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY13714.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY13714.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY13714.1}.
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DR EMBL; JYDQ01000132; KRY13714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZMT3; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR CDD; cd00818; IleRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 16..625
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 668..823
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1210 AA; 139300 MW; 4015F449AE545238 CRC64;
METLHESINF PLEEEKILQL WKKIEAFKTC QERSKGRPIF SFYDGPPFAT GLPHYGHILA
GTIKDTITRF AYQSGFQVER RFGWDCHGLP VEYEIDKTLG LAGPQEIEKL GVSKYNAECR
AIVMRYAKEW QCIVERLGRW IDFENDYKTL YPSFMESVWW VFKQLYNKGL VYRGVKVMPF
STACGTPLSN FESGQNYKEV IDPAIIVTFP LDEDPSVSLL AWTTTPWTLP SNLALCVNAN
LNYVKIRERS SNRIFILMEA RLNILYKSEE EYEIIERFHG QSLEGKKYKP LFEYFAHLKT
ECKAFSILCD GYVSAESGTG VVHQAPYFGE DDYRVCLFNH VITKEMNPIC PVDSSGRFTK
EVTDFHGQYV KDADKGIIKM LKANGRLIQS STVKHSYPFC WRSDTPLIYK AVPSWFVKVE
FMVEQLLANN EKTYWVPSFV KEKRFANWLQ DARDWAISRN RFWGTPIPLW VSDDGEEVVC
VGSIEELQNL TGTKLEDLHR EYVDVLTIES VTGRGILRRI PEVFDCWFES GSMPYAQKHF
PFENYGEFLR SFPADFIAEG IDQTRGWFYT LLVLSTALFG KPPFKNLIVN GLVLAADGSK
MSKRKKNYPD PMDIVNKYGA DVLRDLLKDV FLPWYNAYRF FFQNVSLYEM KHGKRFTAKL
ITPTNIMDRW ILSFTYNLVA FVKEEMKAYR LYTVVPRLVK YVNMLTNWYV RMNRKRLKGD
FGEEESLIAL ETLCQALLLL VRLMASFTPF ITEMMWQRLK TVLDPLAELK PEDSIHYVKI
PDVDRSMIDE DVENHVITMQ SVVEVARVIR DRHALPTKYP IKEVVLVHHD LRVLDMAQNM
RNYILDEVNA RSMMVSVDKA KWGIRSAVDV NLKLLGARLK KDLKPVMDAL KAISADDICS
MMELGPINIL GYEIFREELQ IKYVLGDTDV KDYQAHSDGR LIVLLNVSRD ESMHEEGLAR
EMVNRIQKLR KKAKLLPQDD VMIKCELVSG GDSSKVYSSL CRWREFMEQS LKQPIVFLES
PQTESDHLLI IKENVTVKGC VICVCIFSRS AKASQQSSQL FCPYVDVVDS SGRCVRILLE
NPIRTTFCLW NESSITLYKD KLFQQLLVPT DDTKQLNSTT IYVRAASSSN LPAVTWINVL
IDTTCKACLT LLNPNQSVTV GLLKAKLKEF FPFLSAQNIE LLDASSKIYK DDTALDVSSI
VEQPLLVKCC
//