ID A0A0V0ZPT0_9BILA Unreviewed; 1259 AA.
AC A0A0V0ZPT0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Neurogenic locus notch-like protein 2 {ECO:0000313|EMBL:KRY14137.1};
DE Flags: Fragment;
GN Name=Notch2 {ECO:0000313|EMBL:KRY14137.1};
GN ORFNames=T12_5957 {ECO:0000313|EMBL:KRY14137.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY14137.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY14137.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY14137.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY14137.1}.
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DR EMBL; JYDQ01000123; KRY14137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZPT0; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd01767; UBX; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24044:SF511; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF00789; UBX; 1.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS50033; UBX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 809..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..266
FT /note="UBX"
FT /evidence="ECO:0000259|PROSITE:PS50033"
FT DOMAIN 269..306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 307..348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..387
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 388..425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 536..572
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 574..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 612..648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 1086..1118
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1119..1151
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..112
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 296..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 338..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 355..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 377..386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 415..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 562..571
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 600..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 638..647
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY14137.1"
SQ SEQUENCE 1259 AA; 141055 MW; B2AD14FF62067B09 CRC64;
LLMTEDRHQV GDLEKMDSKQ AKTESTLENQ PEKKVTYMKC NDCGRLLSSQ KAMKQHSLEF
KHCNFSEVED TVAEEEKKKT TQNLYIRMQE MAKQREEKEQ RKEIEAEKER RKMGLEMADY
RRRLELEEIK QMVKQRKQQK YDDYLAKKKI LDEIRMDREA RQLQKNKAAS ASEPSASSSV
GKEETASIGN DLETCTLQFR MRNGSKVVKE FKKTQTWADA KLFADNFFGS ERLEYFTTFP
TRFFNEEDKS KTLLDMKLHP SAVIHVRSLN QKCELNLCEN GGYCFFNEHG NAQCECTPGY
VGKHCQTVDI CMSNPCKNGG SCVYQIEEDE IVSFTCLCPL GLTSTFCENP LPNACDSLPC
KNGICELETL DSFHCRCESG YEGKFCENFT RCKYNLCNNG GQCMVLPDGT YRCVCPKGFA
GSTCESDIDE CTRDICEHGK CTNLFGDYQL SISIDVPVYF DSVVLLGVLA VHASRALVGK
IVIKCNVRAV RFCATTTATA SKLLQTTVAF VFQSTNYPPT LSSSLLGFTG VHCEVEHFNC
QQTVCENGGI CVIANGTSKC LCTEPYTGAT CGTGIGSCFY NPCYNGGVCH EFNDHYTCAC
PAGITGKYCE ISSNRCSADM CLNGGTCFNY NDTFFCSCPD GIFGRRCQFY EAGVEQVEYE
DIVIVVLVEP RTFMSTLSEL LAIINSHMHI NITLKKDELS LPKVYSWNSQ SGYDKNSNAV
LFNNTDETKN NNWKFLIANQ ADAIYGTLAV MTISSSACTR ENSKSCVAKF GEMVNQLASD
AQFDYLKSRV SWNINTVVDR KKKSEISNFL PLIVTVISSL VLIIFFVLLM LQRKRLHAAT
WHPPVEEGPV NLNTTLRSNY LTPLASVLQK STTDKKATNG AQKIFLKSKQ DSFCATDSQT
VDQEKRYATS RDTYKWSDLH LCIIHGVLVD PETITDDQVN ALGPDDQTPL MVAAERCTSD
VELQFMIMLL NAGAKMEAQT ELLKETALII AIRHSRLQAV LALINFGCSL ETADVDGNTA
LHHAVMTRNT EILCALLDSE LCNTETRNND GLTPFVLNAK VCGAVDTEIA FLLLSSGASI
DSTDDEGMHA VHYAAINGNI PLLELLFQRY TNINLMDCYG RTALFFAVRE KHTEAVEWLL
QVGGTMLEMH DQKMTPMSVC IPIDDGHYAT ITFPSAPDGE TFQFPAVQLD DFPNISDSPK
DACCTDLTEE QSYQLPHSSS HFETLHTDTT ESFIPTQQQY WSWCFSKTPP KHDEMIMIL
//
