ID A0A0V0ZRK7_9BILA Unreviewed; 2214 AA.
AC A0A0V0ZRK7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Dedicator of cytokinesis protein 1 {ECO:0000313|EMBL:KRY15334.1};
DE Flags: Fragment;
GN Name=DOCK1 {ECO:0000313|EMBL:KRY15334.1};
GN ORFNames=T12_15202 {ECO:0000313|EMBL:KRY15334.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY15334.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY15334.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY15334.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC family. {ECO:0000256|ARBA:ARBA00007091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY15334.1}.
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DR EMBL; JYDQ01000097; KRY15334.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00866; PEBP_euk; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 3.90.280.10; PEBP-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR035810; PEBP_euk.
DR InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; PEBP-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS01220; PBP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 228..290
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 700..888
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1546..1969
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 2046..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2153..2214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2049..2071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2176..2194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY15334.1"
SQ SEQUENCE 2214 AA; 253791 MW; 8386566D611C0E91 CRC64;
LQSVVAQLSF FSQYIIEVFW FCNMLQMLII KFMKILFYVF LMCRFCYSSM SSLKDKFEEH
KIIPDVVDQA PTQHLQVKYK SGVQADLGNV LTPTQVKEPP SLNWVATPGA LYTMVMTDPD
APSRQNPKFR EWHHWLVANI PGCEINKGEV LSDYIGSGPP QGTGLHRYVF LVYQQKSHLT
DKEHGHLTNR SGNNRGGFSI RKFAAKHDLG APIAGNFYQA EWDDYVPKLY EQLGAKHNFR
PNVVGNYLPL LIGDVVRVLQ FSGEWYYGCL DDDMTKVGVF PISFVEEKHA NFENNELGSI
AQTAVYSVLT VLKEWKKMCR ESFERRGSID IGKIFPMMKD IINWRSQIVS KKLSLEEVKK
LNYKIALKID LGNKMLGADV IVRDIHGNEL QTENCSVAEL HKHHLETAER IATEIEQSSW
NALSHLQRHS SRAEKFMQTK RSQSNWNLLL TFVEFHHPYM NNGELSFMLF DGRLWHGISE
PAVVVVQQNN STRFGVDPAP LQRFIITVRM RIFIIIIVVD LQVGNLCFVV QDLGTKDLDR
EKFWIIFLAT KTGPFEWKDT LTYRKTHVSS TTVRQTFAVA ALDLTELLNQ AFCTDPDAGT
GAGAGAFSST IDEQEERRIF LPLRPLVDDS VEGMLRKIVD NKIGYNSELE TKGDGFWLTL
QPVFASLDEL KHSQPHLFSN PFKLVRKMGF PEVISRDDVR NDLFVTLVSG DFTHCTGRSD
KNIEVKVCLV DELTNSVLPD SVVNVGVAKE TFYTSSVFYH QDRPKWFETI KFSIPVEIYG
NVHIRFSFKH RSSNESKDRN DRPFSVSFIR LKQSNGTVIK DGFHDLVVYR VSSKIEENDF
SYHTLPASKA DLEMSGMEGT SSKFHIQSPT GGFAISPKDF FTICTTVCST SLTQNVDLLG
LLEWETKRVN LKSSLEALMK DEGDRAGEEI VKASLLYVGV GVVVFLQDIL DVLFTVLISC
NDHDQLVFDA LVYVIGLVGE RRYHNFKAVL DSYLLLHFSA ALAYQKLIPI FKDYIDKVEE
CSNKLLKTLK SLEYLMKFIV RSRNLYVQLK GSNAGKERFH ELICSLFISL TTLMLYQTDW
SLLCQGAALK YIPHIVVDVL AVFDARELAA MMANFLKNVP RDRLTKQKLM CLQDLVHSEL
IKKSGAHCNS FARIIVFQYC VLYSMYSEPR AVLLPVILES VRNQIDDNEE LELCAQILTE
IMNVLFDKHS TSGAHSSTLL FIMRTILRQV VQVVVRLIEA GENLILGQYV ALLLAILEEL
DACTYRCYIA EFATRTDLMD FLTELLMLFK DLIRRPVFSS DWFQMIFVQN SIMLKILCYA
ASTVKARFLH EKFEFQVCNS FFQTVVTFIT QKLLQLEQYN VKKRKAILER FRDMRLTCAR
ELVRSMWFSM NLLEKNQFIP SLVGFVLEVT LIPVEEVRKL TIPIFFDMMV TEFYLRANNN
STTTSTPLLG NFSYNSSVME FETEFIKKLD SLVENDYGDA KYVDTFVKIM MQLCSSHTEA
LRDEGIRFTK TVEHLMFRLL EFRNVRLYHN NVNNCMSCTV SLLNFYYEIG HTELYIRYLY
KLYELHMQRD NFVEAGLTMA LHAECLKWCD SSVHALLAHS LFPDCVSQRE LKEKLFLKMI
DLFDRGELWE KAIVVCQELQ HEYEHRTYEY DKLANLLEKM SKMYRNILKH QRAEPEYFRV
LFCGLGFPIF LQNTTFIYRG DGYERLADFT SRIQAQYPNA TLLQTLQPPG EEIKKSNGQY
LLINKVDPIY DDQIKTIPTP VKDSRILWYY KCNDVQKFYF SRRISKKDCT LSKEWPVADE
QENEFGLMWL EKTILVTSCR FPGILRWFLV SSESQIELSP LEVAVDSMKA TISDLEKLIE
EVERYSERAL KPLAAKLQGM LQPAVMGGIK NYEKVFFTEE FMSKGSRKNL EMLELLKEQI
ASQVPLLEKG IFLHAKFCSS DQREFHHLLI DCFKEYKSHV EQHYGKQASL LPENSSLEIP
KSNVLVYKQN LIDGSATSND GRYPFSSSIA SRKSNSVREW QASTSAPWLL RTGVMTTLSG
ATVPRRINSK EAAIRRKAAH STEKEIHQKR HSNSSMGSTQ SAEMSCAGST IVLTEKLTTL
RPPRPDSSFS KGSFKQQSNS SINRLTSSVE KLSISASHSL VHSDSDEILL TNDRIDDHSA
VPPPLPPRRD SGQIEIPDFN ASSVTFSPLS PQRLPSIISG PRREKPLPPL PTTE
//
