ID A0A0V0ZT98_9BILA Unreviewed; 2127 AA.
AC A0A0V0ZT98;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit {ECO:0000256|HAMAP-Rule:MF_03056};
DE AltName: Full=WD repeat-containing protein 4 homolog {ECO:0000256|HAMAP-Rule:MF_03056};
GN Name=WDR4 {ECO:0000313|EMBL:KRY15848.1};
GN ORFNames=T12_5783 {ECO:0000313|EMBL:KRY15848.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY15848.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY15848.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY15848.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC 46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC induce conformational changes of the catalytic subunit.
CC {ECO:0000256|HAMAP-Rule:MF_03056}.
CC -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC {ECO:0000256|HAMAP-Rule:MF_03056}.
CC -!- SUBUNIT: Forms a heterodimer with the catalytic subunit.
CC {ECO:0000256|HAMAP-Rule:MF_03056}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03056}.
CC -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000256|HAMAP-
CC Rule:MF_03056}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY15848.1}.
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DR EMBL; JYDQ01000088; KRY15848.1; -; Genomic_DNA.
DR STRING; 990121.A0A0V0ZT98; -.
DR UniPathway; UPA00989; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0036265; P:RNA (guanine-N7)-methylation; IEA:InterPro.
DR GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03056; TRM82; 1.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR045811; MTP_lip-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR028884; Trm82.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR16288:SF0; TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4; 1.
DR PANTHER; PTHR16288; WD40 REPEAT PROTEIN 4; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF19444; MTP_lip_bd; 1.
DR Pfam; PF00024; PAN_1; 2.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00473; PAN_AP; 2.
DR SMART; SM00320; WD40; 3.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50948; PAN; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000313|EMBL:KRY15848.1};
KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03056};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Repeat {ECO:0000256|HAMAP-Rule:MF_03056};
KW Transferase {ECO:0000313|EMBL:KRY15848.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW Rule:MF_03056};
KW WD repeat {ECO:0000256|HAMAP-Rule:MF_03056, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 388..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2096..2115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 133..174
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1623..1706
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1714..1792
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1798..2046
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 2127 AA; 245113 MW; FC421B20D7206A02 CRC64;
MSLFRKTLSF AVLAVGSKAY GLEIKLDGES ELSVFALNSE ETSENNEEEK KSTEAKIELL
ALALDECGLF AVCDSRKRLQ IFDIRRKIQI FHCTTPKQAT SLVFINDGQS VIIADRAGNV
YQFEPPSSKP SVLLGHISMI LDLIFSPDLR YIVSCDRDNR IRVSNFPNTY NIETFCVGHK
DFVRSLGWMK VDEHLSFLMS ASGDGAIGIW QLPIGKLIYL YNYRESLKRL NSVIPVDAEI
SKLVVYEQCF VLSFFNVSAC LVVQIDFSKW NFQETVLKCD GPVFDHIFAE GLLYVVQKCR
SNPVVLFSFE ANCYKRVESN LQRFNNDAEL CSAVDQCESV ALPLIKFGSF FDKREKELTT
LKNENWKKIA LHLHVYWLLK KHILENMIYF FLLIFLNIFH FFHFYAIAVR AVIQQMFFWK
KLCFEKYLSE MSKIHNRTAI ITGADVGGIG CELVRILLQY NWTVVATVYD VDMITVLREL
FKEIADEHSL VIEVVDFSSL NSIQSFLEKL KRKYDKVNLL VNNAAVMLTP FTEVKNVELQ
WMVNFIAPTV VTNSLHTLVC KAAEDDGFGR IISVSSTELF AASLNQNWFY NGGSNYSNNY
CRKYAYCSYL SYANSKLALS YYMQMLAKLK MQTANFKCCS LHPGVVHTRL YRHTSWLNQR
FLKSAFSKYI LLTPAEGAAN VLWTACSPNL RSGAYYENGI EVSLPKMGIV DDEEALQLFL
REGTQLFFEE ENIMEEEWSL IDIFAHIFTD KVDSEKWFSH GIVINETRLE CNVQRCLQFN
NYPQHHYRIE AISIIPYYDW SVIFNSSNAK AKTVTLINNA NFTFLLYNDQ SVFIRNVNQL
TWESEIFLSA VDNCEIESNF SKCVENWTGS KIFSLFRDCN IGISKILEKW MLQGKTSEDV
ILSFLSKTWH TQHTENLKES ETLTCDSVYK EISSDFHPNA DSRLRSFNRF WKIVNSASAE
KLHKFLFTCD AVQSRQTEAC LNLLALCNTK PCHEAAIKIL ESDQFASFAD AYFNMHAHLT
NPEPWLCVQL LEVFEKKFPQ SESLLYCIAS LLRTTLLKHH GDQVRRCKER FFSLLLQDRN
NRWLGAIANL GEHAHPLLEH LIKLLCTTKG TDSTILKLFD HFSTCSDKLL LLLKRIFSNQ
CPTKQRLSDR ILAVKLIVKL CSSRMHAFKW LLNAVATENW RRDRELHVHS FVQMWNLLEH
NKEIRNTLMK MLPKLGWDFA SSVHAITHFS PVFRPIFASN DIFASYFAAG ELENNILART
IWGIILEYRN KSDSVLSFGI YSSGMQSMLS SSDFKELSFE NEDPVAAEVL FFAFSVHQPS
ISLFNNYSTM YNAIWSADGT PKTVANFGIQ LQNSILRLPL VNGLILTAVC SIFLWLDVSG
SVYISMWYLN ADANMNAVVS VYVDTSFSLH MPKSQRTIWL SDAELFVDVN VNSFGTVDFS
SLPFRTCLQL NSSPFSVRMC QWRGVLEELG REICEQSDYR GQKWTVGLKR SREPCEKVID
CTMVRVDMLW SVLILLFYSN FGISAGCHDD FERYVGFRLS DRLASYVIRR ERSQGGRDFF
QYCHHSCLDD RRCFVYVLNL RQLSCVQYSY LSGNDADLFR KHLITDHDSM VFRKVCLQSA
PRCSRLWRFD ILPKMSIRLD RIDDVHRVDS LAMCETLCSM ENHFQCRSAV YNYVTRNCHI
SKYDRRSMPF DFHAGRSEEV YLENQCVSEP YNECEFSSQH GIAPALAYNE KHTVDEQACR
LACLQNVAFI CRSFVYDIQT QKCRFGPDDT FITMHLPNSS AQLMPYMQIS ECMDVRVLCE
RSEMRAQFRS DHVFDGKVVS MNGSRQCHFD VKKRFQFNIS LPIVGQSKCG ITYETGNVVS
ATVKLQYHDV VWTTKDRMYK LICSYGPVKH AIENSVDVRA PQSAKFQKPS MPLFRETVVN
KNSIPQAFMR IVDTDGNIVT EAEMGQQLFV EIGLERDEIQ QPFFVSSCTA YESGQKMILI
DERGCPSNLR IMSKFLPSYS NHRRVQRAEF RGVTSNWKKR LNLYCNVNFC ETNCPLSNCE
RRLHDQPTVE NDNNHSGKRK RKHLYAAEEQ LETVTVNQTV HFKYNRRGQT PQLGSVLYGS
VAIVLLAVVG FALTWRYRRR LLATMQS
//
