ID A0A0V0ZYW9_9BILA Unreviewed; 884 AA.
AC A0A0V0ZYW9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glutamate receptor ionotropic, kainate 1 {ECO:0000313|EMBL:KRY17321.1};
GN Name=GRIK1 {ECO:0000313|EMBL:KRY17321.1};
GN ORFNames=T12_17119 {ECO:0000313|EMBL:KRY17321.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17321.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY17321.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17321.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY17321.1}.
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DR EMBL; JYDQ01000063; KRY17321.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZYW9; -.
DR STRING; 990121.A0A0V0ZYW9; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF411; IONOTROPIC RECEPTOR 25A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRY17321.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..884
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006874069"
FT TRANSMEM 530..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 405..805
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 415..476
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 884 AA; 103135 MW; 8F428FCDA2331AA6 CRC64;
MPNLILLNYC FFNMKRNLLL LITFVLFGLK EIDTVNSCQI GIFKSRENKT QWSVLIFREM
MHYLMPNAEL SIIDIDSDNN YETEKMDFVI TFAHNNSIIK SAVLEEPTKI PHLKIYTKFW
DMDERNLEYF EPSIYSLIFI SPLNVLVAAL MDLINFMDST AVYILYDNKY KDFFKNEAIW
KAKINKPVTI QMVEKCEEKI HKQMSNLLFN LNDSTYFLHI EQFMKHNSSK WTAISTDTLP
YSNSDSYLSL LFSRPKNVQS LNAVDNFLIW IEKSDHLKSL KNNMDEIEIA FYYDIASLCL
LYFNQTFQNS RTTDDKAKSI SVRKGLLEAL KEYSSLFTQM SAKSAFGVYE LFKNMAFQMV
TLNLYRIREG PDFSRQHLIG NWNSNNRITL FYKSGLSEDI ISQNHYRVAY VLQPPFIEKY
EDENGNWSLR GYCIDLLEMM KEELNFSYEL YEAPDKLYGW PNELGRWNGI MSNILQGDAD
FALASMTVTA SREMVIDFTF PHFDLSGYAI LLKRGESDES FFKFLTVLEL PVWLCTIGSF
LFTSFLLWLF DRFSPYSYKN NKEKYKNGPE KREFTFKESL WFCMNSLTPQ GGGETPRNFS
GRIVAATWWL FGFIIIASYT ANLAAFLTVS RIESSITSID QLAKQYKIKY GVVKDSLAAA
YFQRMAEIEQ RFYDTWKSMS LNESMNALER IHLAVWDYPV SDHFTNMWRY MQETGLPNNL
EEGIEWVLAS KSINDGYALI AEASYLRYIE ITDCRLQVVG EEFSRRPYAL AVQQGSPLKD
QFSSLILKLL NQRKLEILKE KWWKNNPRKM NCPNHDSESK GISVTNLGGV FIVILIGIFF
SLISLLFEYA YFKRKQKRCF PVTTSATDTS KNGDVHMLNY TKQS
//
