ID   A0A0V0ZZ23_9BILA        Unreviewed;       946 AA.
AC   A0A0V0ZZ23;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Hypoxia-inducible factor 1 {ECO:0000313|EMBL:KRY17920.1};
GN   Name=hif-1 {ECO:0000313|EMBL:KRY17920.1};
GN   ORFNames=T12_132 {ECO:0000313|EMBL:KRY17920.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17920.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY17920.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17920.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY17920.1}.
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DR   EMBL; JYDQ01000054; KRY17920.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0ZZ23; -.
DR   STRING; 990121.A0A0V0ZZ23; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF17; PROTEIN SIMILAR; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT   DOMAIN          11..65
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          111..168
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          275..321
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          659..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          780..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          848..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..816
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        866..888
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        889..924
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  106616 MW;  8C3F77588B13E16C CRC64;
     MLPVKKRNVE KRREKSRHAA RYRRQSEAHL FTDLYEILPL TSEPTFYHLD RIAVLRVAAA
     LCRLRAVTPA SMGVVFSFFE YSDLLDSPNQ LPALKDGCHV EQSLYDCFDN SAILIVDSTG
     LIIYVSLSIS FCIGITQTDL IGRSLFEYVH PDDAVDLNQA FQTCDENAEE RSLILRVKSA
     LSARGRSLSL KSCVYKAFSF TLKYAQSKQQ QNSVDIVNVD VALKSLNQRK KRITGNENFY
     GKYFFMFGSV VMQNCQGASF PTETIVTRHS MNMQIRYVGN GLAELLGYDA KLITGQSFFK
     LVHPDDVIRF TLCVQLLYEK GYMRTGYYRM LTQDGNVLWV ITEGSVVSEN SRGQRAQRVL
     CFHRPVGRAC SSVDFSSTVA AKQYVKPPTA SATANPNTMA NITQSVPVFK SRSLSSEVPV
     RPVVTFYDSA LPKELKKLLV SQSSMYGTAQ HTADNSSSSI SYPNDWSSTF YESISEDQTV
     QKGCMPEYQN YDNSNSVSQI DSGNGSSCSN SCAGSFANEA PELSSLTPFV NFQDLLTLQN
     EGYQVNFSFN TNNSGSVEEK GSPPLNITMP SQLKRVASSR LPMKRPYPNC KLDESAFEIT
     PEAGNAIGDP FSPWHPCKMG DWNEQFDQDT PPDLISLETA NLLESAMTTL FQGDAVHNGY
     HNNNNNNNNH DHCHQQQQQQ QQLQLQMQHQ QNCLNGTNEV RVGWKTRQGI LLQMGIRLIW
     VWNSVFKIGW TVHSDHNLAD NFSHASVVQQ WQHGPRYHVV EQGQQEHGHQ ALHDGQFAAK
     PQRAEAGHFP GSEGLTATEQ PERERHHVEE YGRQAGDEVD PAYQIEVVRV HDLVDDAERR
     DRHVGQSLTE HQGDHFVDHG QQDGQSGPPG AEQPPAQTEA QQLTTAHCRT ERSQRHQTFQ
     RDRHYVQRDD RRTDPTEHHV HPLGALGRRH PQRMSALMQH QVQTCD
//