ID A0A0V0ZZD1_9BILA Unreviewed; 850 AA.
AC A0A0V0ZZD1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=DNA mismatch repair protein Msh2 {ECO:0000313|EMBL:KRY17773.1};
GN Name=Mnx1 {ECO:0000313|EMBL:KRY17773.1};
GN ORFNames=T12_12324 {ECO:0000313|EMBL:KRY17773.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17773.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY17773.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17773.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY17773.1}.
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DR EMBL; JYDQ01000056; KRY17773.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0ZZD1; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 722..738
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 850 AA; 97195 MW; D36BC262CA2E8CB8 CRC64;
MDKDLYGIFV KIIEGKSPTN ICMFDRADYY FCIGDDAFYI AKEILKTVTI LKHILVDDVP
QQYITLNKNT FERVVRELLL VHLYRIEVYR CSSTRSQDWE LSAKASPGYI REFENILTNC
EELQEQSRIL AFKITEEAGN ICKLNVSMVC CDLFYHTFQI CDILDNDNLA NFKRILTQLR
PKECLTVDSS VTLNQMRKNI FAQIAIPVTT LKKSDFNSSN VLNDLDMLVK FKKGSHGFCG
SLPEMKVSDS TLQCFAGLIK YFGLVNDDCF LKQFQIQYFT PEKHLRVEWS TFESLNLFRF
GGEKSADNLY GILNHCQTAV GQRLLHEYLK MPLLDKNKID ERLDIVDLFV QNGEIRNILQ
QELLCRFPDL HRLCRKFVIK RAGLPEVYKV YSAVNCASDM LKLLDKMNTS VIKDNFIEPL
LITLNDFQKL TEMVSMTLDL DCIARTGEYR VKPEFSQFLQ DLNNCMQNID QKMTSYLTKA
MKIYGFEQGK SLKLEYSAQW GHVFRVSRKD EKIIRNQKAV ELLDMQKGSV RFTDEILKNM
NSEMMKAKDS YEEFQKRIVD ELVATVGVDK EIVRYFVVGH LDVMVSFAVA SVNAPVQYVR
PKILQPGSGI LNLIQARHPC LEMQPDVSFI ANDLKLAKGE TELIILTGPN MGGKSTYLRQ
TAMIIIMAQM GCFVPCQEAT ISILDAVYTR IGASDNQYKG LSTFMTEMVE VSEILELPSE
NSLIVIDELG RGTSTFDGLG IAWAVAETIA TKLRAFCLFA SHFYEMTMMA SELFTVKNYQ
ALATFADNNL VLLYKIKPGQ HRMCDRSYGI NVAEMVGFPD IVLKEAWKEA RRLEAHRHGG
TTDEDGNDQQ
//
