ID   A0A0V1A010_9BILA        Unreviewed;       945 AA.
AC   A0A0V1A010;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Hypoxia-inducible factor 1 {ECO:0000313|EMBL:KRY17924.1};
GN   Name=hif-1 {ECO:0000313|EMBL:KRY17924.1};
GN   ORFNames=T12_132 {ECO:0000313|EMBL:KRY17924.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY17924.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY17924.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY17924.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY17924.1}.
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DR   EMBL; JYDQ01000054; KRY17924.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1A010; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF17; PROTEIN SIMILAR; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT   DOMAIN          23..77
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          110..167
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          274..320
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          658..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..929
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        797..815
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        865..887
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..923
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  106549 MW;  A9F09E1173C7B90A CRC64;
     MLPVKKRSII YNQIISKRLN VEKRREKSRH AARYRRQSEA HLFTDLYEIL PLTSEPTFYH
     LDRIAVLRVA AALCRLRAVT PAILDSPNQL PALKDGCHVE QSLYDCFDNS AILIVDSTGL
     IIYVSLSISF CIGITQTDLI GRSLFEYVHP DDAVDLNQAF QTCDENAEER SLILRVKSAL
     SARGRSLSLK SCVYKAFSFT LKYAQSKQQQ NSVDIVNVDV ALKSLNQRKK RITGNENFYG
     KYFFMFGSVV MQNCQGASFP TETIVTRHSM NMQIRYVGNG LAELLGYDAK LITGQSFFKL
     VHPDDVIRFT LCVQLLYEKG YMRTGYYRML TQDGNVLWVI TEGSVVSENS RGQRAQRVLC
     FHRPVGRACS SVDFSSTVAA KQYVKPPTAS ATANPNTMAN ITQSVPVFKS RSLSSEVPVR
     PVVTFYDSAL PKELKKLLVS QSSMYGTAQH TADNSSSSIS YPNDWSSTFY ESISEDQTVQ
     KGCMPEYQNY DNSNSVSQID SGNGSSCSNS CAGSFANEAP ELSSLTPFVN FQDLLTLQNE
     GYQVNFSFNT NNSGSVEEKG SPPLNITMPS QLKRVASSRL PMKRPYPNCK LDESAFEITP
     EAGNAIGDPF SPWHPCKMGD WNEQFDQDTP PDLISLETAN LLESAMTTLF QGDAVHNGYH
     NNNNNNNNHD HCHQQQQQQQ QLQLQMQHQQ NCLNGTNEVR VGWKTRQGIL LQMGIRLIWV
     WNSVFKIGWT VHSDHNLADN FSHASVVQQW QHGPRYHVVE QGQQEHGHQA LHDGQFAAKP
     QRAEAGHFPG SEGLTATEQP ERERHHVEEY GRQAGDEVDP AYQIEVVRVH DLVDDAERRD
     RHVGQSLTEH QGDHFVDHGQ QDGQSGPPGA EQPPAQTEAQ QLTTAHCRTE RSQRHQTFQR
     DRHYVQRDDR RTDPTEHHVH PLGALGRRHP QRMSALMQHQ VQTCD
//