ID A0A0V1A2X2_9BILA Unreviewed; 785 AA.
AC A0A0V1A2X2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ileal sodium/bile acid cotransporter {ECO:0000313|EMBL:KRY19211.1};
GN Name=Slc10a2 {ECO:0000313|EMBL:KRY19211.1};
GN ORFNames=T12_11049 {ECO:0000313|EMBL:KRY19211.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY19211.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY19211.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY19211.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY19211.1}.
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DR EMBL; JYDQ01000038; KRY19211.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1A2X2; -.
DR STRING; 990121.A0A0V1A2X2; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 1.20.58.1070; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR035426; Gemin2/Brr1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF28; RH04535P; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
DR Pfam; PF04938; SIP1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87407 MW; 6EDB89C192183497 CRC64;
MPQVFYVPKS KQRHPVDLNK PPNSAVDYLL QVAAEREQLE KTLSSESKGG KQNSSSSKSV
GKQNLGHSVS QEAPQQESAL SYCEVVEHFE KFRLRIPNLR KLAYRLGNVG DVSLPSAADE
KGWKKFFTDI VHSKNCENSL PLLSIVLSLD DKQIEQAIIL SLFVLYSHGY DHSLLQWLYA
LLALTFFPFS DQFRMRMKVL SSYCSMNREK LLKSNPKAAR SFIYKPLSYF FLCTGKKILA
NILIKLLLIL MEMKTDCRCP FLLLYYCVLS FVCAVLWSAV HVLGNGVNIT VVPEVISSIK
ENENQTVIVH FQRDDDLDKC EIQCSNKLNL SLQTSTPDLI DITNPKKFSS HAAASDYDYS
LTTTDDTVQN SSSQLIQLDL EHFDEITFTI NGKFLGRAVV QLDVVCLDDE GIEHNFTLNY
PVPVIRADSK LGYIFVGVLS ILLCLANFLM SAEINPRTVW KVIKRPVAPA IGLFCQFFAM
PLISFGVAQV AFVPYGLTAM GLGLFTAGCS PGGGASNAYT YLLDGNIDLS VTMTFLSTVF
AYGFMPLWIY LLGPYIVETD ALRSIQIPHR NIGISLLLLL VPVNLGILLW HLKPSWGQKA
KKVLRPFFVI IIVFICTFGV YSNLYMFKLM SLRSMIAGLC VPWLGFMTGF VLAWLLKQPR
ENIVAISLET GIQNTGIAIV LLQLSFPKPD SEIASVMPVI VALFTPVPVL IALILYYGKS
FFWKVLEGIP CVNNCPGDSS EKGRKLNTDS SLDGTVSVPD EVNSVDGMSV NGKTADSQSM
IFIKR
//
