ID A0A0V1A2X8_9BILA Unreviewed; 631 AA.
AC A0A0V1A2X8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE SubName: Full=DNA mismatch repair protein Mlh3 {ECO:0000313|EMBL:KRY18948.1};
GN Name=MLH3 {ECO:0000313|EMBL:KRY18948.1};
GN ORFNames=T12_3434 {ECO:0000313|EMBL:KRY18948.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY18948.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY18948.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY18948.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY18948.1}.
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DR EMBL; JYDQ01000041; KRY18948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1A2X8; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 400..562
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 631 AA; 72749 MW; 458A4AAB596C2BC0 CRC64;
MDRWQFHLNL AYEVLSFSDC VQILLLNSLR ASSSIVVIRV HVEKFKFQII DDGDGMDQTM
LTSSDKMPAY LKDVCKLADE VIIHSRPRGR AVGFKARYCA ALKRSVDGSR TFSDCFFLKD
SVQIQSRKCH GTTITVQKLF SKTPVRQKSV KPSQELENLK LRLRWISVKH PKVIIELHDE
SDRSCVFRTT RCETLSESFL QLFFEIYPHQ LSDQIRFENE DFKLSLWIGT EESNTASLQC
IYWNDVPIFW QTELHTFVIS LIEKLKNGRK DSCSVFLLTI DTPLVERFMV EGLRAVESCY
KWKRLLEAIE SLFQKPLSNG DSLQNEKLLS KGNRCLLPGC KFSFQLYENF TNSLPLLNDE
KRSISQTSIY SNSTSKCTVE ENSNILVEDE MQLVAVPSPV IGQYDCKFVI CRATVESKQN
DRTALLLLFD QHAVSERVRL EQLLREHIVE GRIARARLSH PIEINFSNSS EWFSSKDIIE
RYGIEINFEN SRYLIFTVPI CFARGKWNIS QNSCITARFL KSVFQQILEF GSLPSRRKLP
SIFRRSFADW ACRGAIRFGD RLTLNQCQNL IRQLVECEAP FHCAHGRRSV VPLFNLSSLD
SRSANNLTSE KEASILREML TTIGIEQSFN T
//
