ID   A0A0V1A3J6_9BILA        Unreviewed;       821 AA.
AC   A0A0V1A3J6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=TWiK family of potassium channels protein 7 {ECO:0000313|EMBL:KRY19439.1};
GN   Name=twk-7 {ECO:0000313|EMBL:KRY19439.1};
GN   ORFNames=T12_10764 {ECO:0000313|EMBL:KRY19439.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY19439.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY19439.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY19439.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY19439.1}.
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DR   EMBL; JYDQ01000035; KRY19439.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1A3J6; -.
DR   STRING; 990121.A0A0V1A3J6; -.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF333; TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 7; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:KRY19439.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        27..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          109..167
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          229..300
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   REGION          566..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  92812 MW;  11E1F2DDBEA59800 CRC64;
     MPSEADPRWT SEVLSIRKFV HYFKLSLPHV ALVVVCMVYA ILGALVFYYI EAQNERFVKS
     DKIQRIVDST PSKRLHDLKV VLCEAFETDF VTVDMIDYSS SGDANEISNS VWTIQSSVFF
     AITTMVTIGY GNVVPMTAEG RLLCIMFALF GCPLAIITIG NLGKFLSETV VFLYNKIQRG
     KMLLMKNIAI RFPLLKGLNN YDNFETTSLT YEDIVVDDTG ISAFFVLSIF VFYNAAGALL
     FTSMERWSFM DSLYFCFISI STVGFGDFVP KNDPWYIILY CYTALGIAIT TMCIDLVGTR
     YITKIHYFGR RLKGADLIRY LRHKRIKEEK QLLALKTTEC IESYLKSINQ IKEPTEVLPE
     QISYNDDTKF EESVPFLNRP ANVLHFPLDN EPLLSEEIEQ IEVQHFSLVK STNLPNMGTY
     FLSSFWSSSV ETSHQSVSSS NNEKVEMSTF PLSDTVSLLE SARNKLSLFV RNERPSSVKS
     VQLYCSDQPK DVGVRRAYST EMPLLFNEAN SLPEDLLFSK IEPSNNEHAD IQSQPDTGNS
     ELSDSVKGFL MTQSNEILSP TETENFDLSE ISSSSPNISE LSPVSSLTSS PTQSIEVENA
     SQGKFVFPQV NDPDEWPDKL THDLCFVLDG GKLQEEKNTS RILFQFAYDI LLCQTSLLTK
     KDPNWTCHVH PAKFYHSANM KIFERVNAVI SGGKVVAAYP TSKSRKSFAA SSKFIPSLVL
     DKSATVKSTD SRLSIAKSAK RAESLSPKDV YKTTRVYSFW KRCPSFHRIC TIIQPNDPGA
     KIRSHIYVQY IWRDAKEKDK QAVIGEIKRQ KLSLMPSFIS T
//