ID A0A0V1A427_9BILA Unreviewed; 863 AA.
AC A0A0V1A427;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN Name=Smad4 {ECO:0000313|EMBL:KRY19246.1};
GN ORFNames=T12_6894 {ECO:0000313|EMBL:KRY19246.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY19246.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY19246.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY19246.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY19246.1}.
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DR EMBL; JYDQ01000037; KRY19246.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1A427; -.
DR STRING; 990121.A0A0V1A427; -.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 318..445
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 639..863
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 241..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 91745 MW; D22317814F8B56C9 CRC64;
MKISPKPNGC QEVPANVSNF CSVNAQHSQT PSGGFPIRAA VGGLGVGVGR IEGRGGGGGS
GGGGGAAAAA VATVTGGTAA TMATTAPPLP TAAPVAVGAD GRAIYASSAY SAGKIPVNNY
PNMATLLNSD PLSSNTHEYE TRVTVEAVSS VNDGQQRHKA QLSICTYASP GSIAGGDMET
PPEITHPISS PCMGALTSGS GGGGTPTAML MQNPCANQGG AMMSTCVSAY HHPVNMNMQQ
PMHHQQQHTG VQQQQQQQHH HHHQHPPPPP PPPPPPAPPS QHSQHHHQQQ QQQQQQQQQQ
QQSSSSIIAA SHQSSSSDAC ASIVHSLMCH RQGGDEGFSR RAIESLIKKL KDKRDELDAL
IQAITTGGSH VTKCVTIQRT LDGRLQVAGR KGFPHVVYAR IWRWPDLHKN ELKSNSYCQY
AFDLKVDLVC VNPYHYERVV SPGISNLDFS ALRLDATSPS LKTEFGCGLV ESPTGAGVSK
PPSSESPLSP VAKVDANTDL PPTQNIAHLP QMSQSAGSAY PVVQGAAEIM GPSSVDSGHT
SVPAPSTTPN WGSQQQQQQQ QQQQQQVSPA SPHQYQRQGF HVLPAPTATL QPSVYGSAIV
WPLASVDRNP SFFVTSARLS ALEAEMNTPL TTQPMPDFWC SIAYYELDTQ VGETFKTPSS
HNSVTVDGYV DPSGVNRFCL GALSNVHRTE VSEKARIHIG RGVRLDLKGE GDVWLCCLSE
YSVFVQSYYL DREAGRAPGD AVHKIYPKAY IKVFDLRQCH RQMLQQAATA HAAAAAQAAA
VAGLVNDPGV TGLPPAVSLS AAAGIGVDDL RRLCILRLSF VKGWGPDYPR TTIKATPCWI
EVHLHRALQL LDEVLHTMPG LTG
//
