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Database: UniProt
Entry: A0A0V1A6W9_9BILA
LinkDB: A0A0V1A6W9_9BILA
Original site: A0A0V1A6W9_9BILA 
ID   A0A0V1A6W9_9BILA        Unreviewed;      2017 AA.
AC   A0A0V1A6W9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   28-MAR-2018, entry version 15.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|EMBL:KRY20600.1};
GN   ORFNames=T12_7833 {ECO:0000313|EMBL:KRY20600.1};
OS   Trichinella patagoniensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY20600.1, ECO:0000313|Proteomes:UP000054783};
RN   [1] {ECO:0000313|EMBL:KRY20600.1, ECO:0000313|Proteomes:UP000054783}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS2496 {ECO:0000313|EMBL:KRY20600.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRY20600.1}.
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DR   EMBL; JYDQ01000023; KRY20600.1; -; Genomic_DNA.
DR   Proteomes; UP000054783; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054783};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054783};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    146    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    184    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    217    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    277    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    358    379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    413       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    522    538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    558    583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    590    608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    665       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    686    703       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    715    738       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    883    901       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    921    942       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1015   1034       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1125   1152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1204   1221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1228   1247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1293   1313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1379   1403       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1541   1575       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      756    776       {ECO:0000256|SAM:Coils}.
FT   COILED     1501   1521       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2017 AA;  230101 MW;  88886C0A70C58192 CRC64;
     MGGEGKKKYL CWHRESRPEQ VVPSPIAEPR VASIQTMIVR QVRHHARSEA NFNDDVNIGK
     ELSGNEAAAL LHGDEARASR ADLWQQTLQA AVAAQTESST TTKKRQQQRK MQRNVQQERP
     ERSLLCLGLK NPIRKLFISI VEWKPFEWLI LCMICANCIA LAVYQPFPAH DSDRKNAVLE
     QVEYIFIVVF TIECVMKVIA YGFLFHPGAY LRNGWNLLDF LIVVIGLIST ALSTLNIHGF
     DVKALRAFRV LRPLRLVSGV PSLQVVLNSI LRAMVPLFHI ALLVLFVIII YAIIGLELFC
     GKLHKTCVDQ WTGEHVPDPG PCGESHTSFH CDRSKNLVCT ENHTWPGPND GITNFDNFGL
     AMLTVFQCIS LEGWTDVMYW VNDSVGREWP WIYFITLVIL GSFFVLNLVL GVLSGEFSKE
     REKARARGLF QKFREKQQLE DDLKGYLDWI TQAEDIDLVN EEDEEQEAMD REEFGADGEG
     GEEGGSKEEF QRQSWFSMKI KRLKKLNRRC RRSCRRIVKS QAFYWLVIVL VFLNTMVLTS
     EHYGQPEWLD HFQEIANLFF VVLFTLEMFL KMYSLGFVNY FVALFNRFDC FVVIGSILEF
     ALTFAGLMKP LGVSVLRSAR LLRIFKVTKY WNSLRNLVAS LLNSLRSIAS LLLLLFLFIV
     IFALLGMQVF GGKFNTIDPN MNKPRANFDT FVQALLTVFQ ILTGEDWNAV MYNGIAAFGG
     VHSIGVIVCI YFIVLFICGN YILLNVFLAI AVDNLADAES LTAAEKEEEN KRANEADPED
     DMVVKATADE DAVSVGQFHE SGEVKLPFNE PTDAEDEHLA SGDDDHEREM ENQSQFKPTA
     RPHRQSELNL PKKTKPIPDA SSLFLFSSTN KVRIFCNKVI NHSYFTNSVL VCILVSSAML
     AAEDPLQASS FRNEVLNYFD YFFTTVFTIE ISLKVLVYGL ILHKGSFCRN AFNLLDMLVV
     GVSLTSFGLK SGAISVVKIL RVLRVLRPLR AINRAKGLKH VVQCVIVAVK TIGNIMLVTF
     MLEFMFAIIG VQIFKGSFFR CTDRARLTAE ECKGTFIEFE GGDVTRPHVR NREWTNYDFN
     FDNVQNAMVA LFVVSTFEGW PDLLHVAMDS SDEGIGPQYN ARVSVAIFFI TFIVVIAFFM
     MNIFVGFVIV TFQSEGEREY ENCELDKNQR KCIEFALTAK PQRRYIPKNR FQYKIWWFVT
     SQPFEYAIFI IIILNTLILG MKNYFGDAWN VFDFIIVLGS FIDIIYGKPG SNIISINFFR
     LFRVMRLVKL LSRGEGIRTL LWTFMKSFQA LPYVALLIVL LFFIYAVIGM QIFGKIALNS
     NTEIHRNNNF QTFPSAVLVL FRSATGEAWQ LIMLSCANTP AAMCDPESDD RGQPCGNDFA
     YPFFISFFML CSFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFVRLWS EYDPDAKGRI
     KHLDVVTLLR KISPPLGFGK LCPHRLACKR LVSMNMPLNS DGTVCFNSTL FALVRTNLKI
     YTEVSSNIEE ANEQLRAVIK RIWKRTPQRL LDEIVPPSGR DDEITVGKFY ATYLIQDYFR
     RFKKRKEVEQ KETNMQGNIT MSLQAGLRTL HEIGPEIKRA ISGNLETDWS KEFEEPQHRV
     GKKKTSSNRI KFSAGIITLR DHSLFGTLVH ALQAHYKPFI EGNLTNPAYS NVNGDLKSQE
     GDDEAEQQHQ QEQQEQQQQL MFNKMNDLKS PPVKSDRDKI SEFESDESVC NKPERRCNSF
     FSNIRRRMDS IVSPSIVLFD SDHDSSEHEM QERVRFVPRG SKPTGLSFEG SRWLPRKLSF
     RRTPIGGAAA VSNLQQGNNK RLQFSNAIIL DDSDPDSVLH SENVVDLTES GDDSKLSVSP
     PLELRDDAYY LDGIDYNTWR PAPMGQGVRL RGRGNGRRKS RSMPLPHHEH QRNYADVLVE
     KVLADQGLGR YADPNLIRTT QLEIAEAYNM TEAQMHSAAR SLMQRSPKYF EHMGGQRPAD
     IKDFNQYSKT ALLKPREINS SEEVDISDDM NMFMSVV
//
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