ID A0A0V1A7A6_9BILA Unreviewed; 2974 AA.
AC A0A0V1A7A6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KRY20722.1};
DE Flags: Fragment;
GN Name=Nf1 {ECO:0000313|EMBL:KRY20722.1};
GN ORFNames=T12_7116 {ECO:0000313|EMBL:KRY20722.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY20722.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY20722.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY20722.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY20722.1}.
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DR EMBL; JYDQ01000022; KRY20722.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR004405; Transl-rel_pelota.
DR PANTHER; PTHR10853; PELOTA; 1.
DR PANTHER; PTHR10853:SF0; PROTEIN PELOTA HOMOLOG; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 1350..1542
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 534..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2584..2603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2640..2667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2699..2776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2646..2667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2702..2722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2757..2776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY20722.1"
SQ SEQUENCE 2974 AA; 333179 MW; AF27CFA198BE03BD CRC64;
LLSNGIYIYF CRKLKLFLNV MKAFSFQKPL EWVSSLLARF EDQLPVKTGP LKNQSRLLLE
QSRACLVNVS KLKFSMVVGG LIRVLQTVNS MKTSSEQDLF DSQCFILDTL ERCLAGPQDV
SSRIDEANNV KIIIHEMCQF IQLSSDSNQA IQLKEKASKV IYNLSLSSFN VIFNRIVAKL
KAVSCEPSAV SVPSDLMASS SDNVDIELMQ YIHFDLKSLI KLLREISYHK PFKKENNQIL
FRSLENVIWN WMDTYPDEFH NLQVEQNNEL NDCCDRLFDQ LDTYGAESSK RKAIVWPLQM
MLLILCPKVL EEIHHISCGA PCPIRLVKKK VFFDSIKKTM SQGHSHTCKH HLLSSACIAG
VKLCKAAIYV NVVDSANVFF ALLQSIITDL KSYLFNPIKP LFKNPSSAQE LDVMIDCFVA
LFRLSYNNEV FRICLNAHTV VPHQLVLVMA LYRIAVQARL PWWPKIDLVY SRSGELLQMF
NETLSRVCQG VSVVGCLLPT SSSTTCQPSS HGQTSTTHMP LRVTHSLHRM TGKLKEKSLA
GSQPSATGGA GGGAGGGGCV GGCTVASAAS VSSLTGNANS SSVEDGCQQL LFWLIRLMCI
EPTLFLHHGP ESTSTVAPSS STAELISGLV NLVGNSNQMP ELAQEAMEAI LCLHHPENIR
MWHPDSTFTT VQSLWYISSQ LLFYICQKLL QFQLANFSET LRWLRQLLVY RNLYLLSNRE
IANYGSSEQL CKQAAQKLET VCFVYLWSLD NDTAITALSV FRILCEEAEI RCSGDELPVE
YADYAELASA TNLQTVGRVV LQKSINSYLK KLLIPSAGCC EAWEATYRYW EALTKFLKAY
PKSKQEDSYQ VVENLIKQLV NQKLGRSSEQ EFEMTVKLWA NMTGFLCSVG GVVIKSCKNT
TLYYDSSGNL PPSAETSDKS TTATTATADD LSTSTPDLFC SVNNFLSQLL TLLLVQSDKL
EVAVVRHIKE ICSYELHQLL IGHFFEQIRT ITDRFIDNDD VIIICLKNTE FIEHVVYIMK
NILLGCCKQN VRNVEISCIE PIMLNLCRYV HNLEVNYQSV TIKGKICQLI EVIMRNYENI
IFRSEIRFRN RLVDMIADWV ICNNSPSASS CIAAVVGVGA FPSEASLPLR DFNTLCMVAL
GALMRDLPLQ PNCPPNLTTG QTNVQNTAVL NKSQLFQKHF GLFMNVLNDC AMNENTGAGD
FDVETVSRGD ETSSQPLVNT STSSSVPLVR GAGRAGAGSG AAGVGRRFRE TKTEQLRRAT
ILAMSNLLAA NIDIGLVHAV GMAYHRDRRA RVAFVEVLTK ILQEGTEFET LNETVMADRF
DELVKLTTMI TVDGELPIVN ALASVVQTEH MDELARVLTT LFSSKNLLHE LLWKLFIKEV
ELAEAPTTLF RGNTVASKVM GYCFKLYGAK YLHSLLHDFV NSTVEHSTSN YEIDPSRLET
DDNLAENTTN LMELVENILS LIVHSADRFP VQLKGMLNVL FYVVNARFPN TGLLAVGMIV
FLRFFNPAIV SPFEYGLTEN YPNANVKRGL MLVSKILQQI ANQTISLKES CLQPFNAFIQ
SKFEPTRRFF MNIAVEFRFD ADASSQYYMS YMNDTPTCAL HRLLWQYQDR IGEFFTTMRS
HDRVARRLAT LLAQLGPANG RAGSKQWTNV DLNSTRFEEL MSRQSAADKD EYNSIKENNI
FYQCGISRAS NPVFYFIANR FKVGEVNGNM LIYHVLMSLK SKRNEHFELV VDLTHASTEN
RFRTELLHKW FLVLSEAMQQ NIIAAYICNC NSWTRDYIRF HERLFSPLKA SHKLYFLDHV
RQLNDYISPE WQRLPASTLQ IDDDVLTFNN ALKICHKNMK CSIKVGPTSL QITTLDRQKV
LGHNVILNDV YYASEIQEVC LVDDNSMTLT ILNECSPLTL MHADCEQIAS AVVNLRTRYE
LSQPDQAVLH AKIRAKDVPG TLLNMALLNL GSTDASLRTA AYNLLCALAA TFNFHIEGQL
LETEGLLIPA NNTIFIKNIS EKLAMNETHL TLEFLHECIQ GFRQSPIDLK HLCLEYITPW
LANLPRFCRV SGNDNSKRRA VAKVLDKLIT LTIEEIEMYP SIQAKIWGSI GRLSELLDII
LDRFLKRSIT GGFGSMPAEV MADTSVALAA ANTKLVSDIL IGRLMQVLEK SCLNPQATLE
EHILWDDIAI LARYLLFQSF NNCLDVISHL PVLFHFVTVL VNTGPLALRA SIHGLVVNVI
HSLCTCPSSF SGIRLKISLS EIDKTTKANL RLALTEFFLP KFYRLFGVSN LTVKSVAATA
FRISPRMSLP IHCSGDYMAS GSIAPRQDRL TLPNLETIAD SLVDLLETCN QDIKNRNLCN
EWEKISYYFT MRFNPALQSR ALVVYSCLSK KTDESVIKQL LNLLLQFVKR RDDCSLLSAV
LMALRRLTPL LPSVVLQAIH CTLLARLFWI SVIILQLEDP SLYEHGLALL EQILRSLDSL
NVFEYEPFEK VMMEARPLLE WEFKAMDQQM GISFKHNFHF AVVAYLLKGY RHPSQSVVSR
TVRLFSLILG IVAKYTKRDR YEVTVENVAY LVALLPVSEE VRLRCPLRHS TLRALSLCGP
SENASNNDPT VGSFPSPGRA DKLQPCSRRS ALCIQRLQRS CDDSLQTLAV AGSTVGSGKL
MRTVTGAGDT MSSRMWSPSS SSSSSVSSTA VVGFTGQRSR SLPLSELSTC SLSLPHADNR
EQQKQQQQHE HEHPDKTEQT CKNSNGDDGP GDLASKTTAA EITKSEPTDE SQESKAEQQR
LSNSNGKSGG GPTGQSSRTA FYENLLLDED VLCEPSLQVL VLTVLGTLVR NYADENETRT
LFEYLAEASL VFPKVFPVIH CLLDQRITQV LQMSHDAAVL RAVLHIIQNM IPSQETTDTY
QQQHLTLLQS YGFGGFWRFA GPFSLKSTAQ LQIAPESLTC LERLIGSLGE VHLLTPPPLS
PFGTSEFGYF RQESFSGTSR ANSVTLERSA TSDC
//
