ID A0A0V1AQT0_TRISP Unreviewed; 1865 AA.
AC A0A0V1AQT0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Protein HIRA {ECO:0000313|EMBL:KRY27158.1};
GN Name=hira {ECO:0000313|EMBL:KRY27158.1};
GN ORFNames=T01_7257 {ECO:0000313|EMBL:KRY27158.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY27158.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY27158.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY27158.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY27158.1}.
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DR EMBL; JYDH01000278; KRY27158.1; -; Genomic_DNA.
DR STRING; 6334.A0A0V1AQT0; -.
DR InParanoid; A0A0V1AQT0; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.10.290.20; Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 62..444
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REPEAT 655..686
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 711..743
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 754..786
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1313..1507
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
SQ SEQUENCE 1865 AA; 208645 MW; DD3CEEFA59B4B836 CRC64;
MVIWRARPSG GFFKYFIDAQ LAQWRKQPLS GAQRSSVNVS ARGPLDHLSI RTKIQSTKIA
SDFTSKKLLV VGAGGIGCEL LKTLVLSGFA DIEVIDMDTI EVTNLNRQFL FRKEHVGLSK
AKVAVESVSV LNPNVKLVYY CKPIQSREFN VNYFKKFTAV LNCLDNIEAR SYVNRMCLIC
HLPLIDGGSL GRKGQVDVII RNITECFDCH KHSPSHDYPS CTIRNTPTEP AHCVIWAQHL
FNQLFGEVNS DQDVSPESLV TGEEFEATPQ VQPLTNVISL QDLAKNHNYD PEVIIKKLFV
NDIEYLRTME KLWEDRQPPT PLNLRWFRIG LHENLQGTEQ KDWESRDQNV WTLKECFKVA
VSCLAVLKER AKNAPLIWQK DDPVCVDFVT AFTNFRCHVF NIEKIPRFEA ETIAGRVVPA
IVSTNAVVAG LMVLKLYTVL ERRKDFYGSV AISSQEGMPR VLSIAPSTEV TGCEYCVAVK
EVEVSLNVST FSVENLGKIA KELSVMKPEI MLEVASPRLL FAHDYKLSAE EGKKTLSEIS
VKHGSLLRCE DGATFTNIRI IISDCPEIYD SDENCRRNLF IKVNFDSIEL IGNEVHKAEL
GLPIYSVDIE PAGNRFATGG QSVTGIGLIV LWSLKPVIDV ENETNDKIPL LLCRLEAHST
CINCIRWSSD SRYLASAGTD QAVKIWRFVS YIPNVQSRVT AVEHWKCVST LHGHAGDVLH
LSWSPGDRYL ASCGIDNIII IWNAKKFPEK ITSLVGHEGF VKGVCWDPIG KYLASQSDDR
SLRIWSTVDW NVVHKFRRPF KEAPCATHTL RLDWSPDGLL LATAHAVNNG GPVSKIIERN
GWKCELDFAG HRMAITCVRW SNVLYHRNRK VFLTEKSNVC SCCAVGSKDR SLSVWSASEN
RPVVVLTDIF ESSISDISWD SSGLILIAAS VDGSVVCLVW TTDELGVPLS LDEKINKLRR
YYGNVDVGLL GLQRKSDQNS NKIIEDADYV MTHAKVIANR SNENGVNGGV CASTTAVRTA
PPPSTRDSNW NVQLETRTKS GKRRITPINV EVVAEVDTDN NSQPPWIREG VGLGVAGKAK
GLIDEKMTVV DNAERWSGLN STTVEPLVPL VASSSSSAFA SKSTSVKLRK GDGFDAGGKS
ISKSSEDHSG GIVEEFLEKS KSELKFDKKK SWHQKGKKAL KHAQRESTIS QTFPSSETEV
EVETDFQTHQ TVAVSSSSKQ KTPTHRLEAL KVLHLLMCSV VVDESESEML LQLSNNVGSN
PKGKFAELLC MKNLNCVWKI LLETGAVALK ANRHLILVVF ENGMFDILSP LDGRMMCLTN
VLGDSVHYVD LDGKHIALVT VCAELYVWSF VKSLELVCQV SLKALLRDPK RNLSRVVFSA
VGMPIISFND GSLFSYDASS KIWQKLLNPS DSFIKYSPTS MLASTKAYLK TKGRFQNLCK
NLFSSVTFTA ESDSEMQERI REGFLERFSL ASRAVGSEHE YMYWLSEYVK LLVKAESEVK
LRCLFRMLVE SDEHMKTNSM LSRDKNEKRS AVTDLLPLVA ANPKLQRLYS ELSFLVAEKS
SSEQADDLYS EIAATRVGCN LIAKYYATDS LKLSCDVVSV EKFMKSAPEE KSSHMSMAVI
LLNKMNKRCV GYVLKSDKDS SSGSRFILTT RTCSANFNRQ INAPIYILPE NKERHVKAIH
TRGFHESLAV IEMQDKYPFK LASESTCPLE SPEISEECFT VYAVENQVNK RDIVAEPYKS
SPKSSCEKYW ITFNEESFAC AATSQKEKRN GLGLVCSQGG KLALVGISSE NQQTTSVTSF
TLLYPYAKQT GKRFHPSYKI FQFLENVMQR FATKNEIALF TFLKFNTVIL ELLCKKQFSE
MLTRK
//
