ID   A0A0V1AVP8_TRISP        Unreviewed;       959 AA.
AC   A0A0V1AVP8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=FYVE, RhoGEF and PH domain-containing protein 1 {ECO:0000313|EMBL:KRY28887.1};
GN   Name=FGD4 {ECO:0000313|EMBL:KRY28887.1};
GN   ORFNames=T01_12313 {ECO:0000313|EMBL:KRY28887.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY28887.1, ECO:0000313|Proteomes:UP000054776};
RN   [1] {ECO:0000313|EMBL:KRY28887.1, ECO:0000313|Proteomes:UP000054776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS3 {ECO:0000313|EMBL:KRY28887.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY28887.1}.
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DR   EMBL; JYDH01000188; KRY28887.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1AVP8; -.
DR   eggNOG; KOG4424; Eukaryota.
DR   Proteomes; UP000054776; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00065; FYVE_like_SF; 1.
DR   CDD; cd13388; PH1_FGD1-4_like; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF241; PROTEIN CBG10230; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054776}.
FT   DOMAIN          354..561
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          591..699
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          836..936
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          112..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..327
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   959 AA;  108957 MW;  C42CFED9D18F59A6 CRC64;
     MNESETQPAK VVLQFLFISD FSLEPSVDDR TAVRGKLIAS FWQRQMDDSD EQKRAGFSWQ
     KSSTASIDRP LAAPLLQDAA VASLLDLRNI GCALAFLQPD GSGSADAAVY STSTMSSSTR
     TVNTDTSSST TAQGQNPSTQ TVSSKKTYNV TSRVTSTRHS SREVTLNTGG KDLASLDLAD
     LAKELEKHQP RESNGDLTMP FLDPAQLAGV DSPAAIIFQQ LLNVEKERFA NLFPQLRCVR
     SSPAPLETTV RIIRNADGTV TRIQTVQSRS VIRCRQVTKQ KGDETKSTVR AVVHYEGPGG
     KVRLKLEDDG SVDSEESGGE DDDDDDGHLQ LSPAKLGLPS PNSDEPLAEG APDKAFYAAQ
     ELVDTERRYV GKLILLVERA VKHEKERNLN FVLFFLKTFK KRIEQENSNG RLIPVQKSRA
     LFANLESIYA FHKQHFLPQL QNRLREWPRE QKISDVVCQQ APFLKMYSEY INNYKRATKV
     FEELYKKGGK FAQIVDEVER MPECENLSLV SHIIGPVQRV MRYHLLMQEY LKHLPENHCD
     RQDTEKALEL VKSAASHANE IMRKLDKYKD LVELQEQLGC QVIELVSPSR ELIKQGRLLK
     LSSKSDEQQT RHVFLVGYTR LNIFALNDML LVCSERKVPI HKYKLRSLLE ISGMTVLEGD
     YLDIENTFYV RTKRKVIAFC AGTFKEKAEW MESLWSTIRE LAAQRQSFRM SGRKFSKLDD
     RLPRKTCSLC TSTFSIFRRE YTCQACRKRI LTLCLFCVQR LSARNAVRRI KCRLHTKLER
     KSAYAVRALK LFARTTVQHN ANIEMHKTTA ALVACGVKKQ SCNSLFLYLY LVPANDNMLE
     GYLEMRSLKR PWTKSFFRLK NDFLLYRYAD EKDKAPVASM PLPGIKVSLL DSRQESNGLS
     EWNQFVVEHK NRSYVFRCAT QEEMAKWMAV LDLASKAEIP SGESPICKNL DQVLCTSDQ
//