ID A0A0V1AW63_TRISP Unreviewed; 1473 AA.
AC A0A0V1AW63;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Protein patched-like protein 1 {ECO:0000313|EMBL:KRY28966.1};
GN Name=ptc-1 {ECO:0000313|EMBL:KRY28966.1};
GN ORFNames=T01_459 {ECO:0000313|EMBL:KRY28966.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY28966.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY28966.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY28966.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY28966.1}.
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DR EMBL; JYDH01000185; KRY28966.1; -; Genomic_DNA.
DR STRING; 6334.A0A0V1AW63; -.
DR InParanoid; A0A0V1AW63; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF1; PROTEIN PATCHED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1161..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1216..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1255..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1282..1311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 631..790
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1473 AA; 164253 MW; 7DE6869A17BC035B CRC64;
MDINTDKSKT ASAPVADPES GRFTTRSISN AASIVKMGRA KLCLYDRELQ RMLPAQVAPP
LQPRCISRLG RLPSDMVQID TSKWGEEFRR RPSWVDAGMA LRLIQSDKAK GNKPALWIRM
LLQRGMLCLG HRIQRHAGQV LFFGLLMLSI CCIGLRLVAF ETDMEKLWIE KGGRLEEERN
FLSENSARLP NGKLRSVEHA DNRDEVMVAN TGDAFLILIQ TPRKGKSNIL TKDDLLLHEK
VVSEMGRMTI SLFGETWGLE DICFRPPAPS IEGAISEIIK VLLDKIIPCT LITPLDCFWD
GSKPLGPNPP LKIGAEIQTF VPSLQDQVTW KNLNPQGVID DVKTLGIFDI SIFDNFLERS
GIASAYQHRP CIEPLDPECP STAPNYINMC PVVEKFLAWN LKAKQYSFPN ITMDVEKLLM
GNDTVDSTEP TTTTKPQETS MYEQEYNTFE EMFGSIREKP VMTEPKICRL FKEDVRSLLL
ANETLRRQFL PAAAFTNYST IMTGGCRGYA ENFMKWPEDL IIGGITKKDE CRRNIEFVKL
IDCFRAEALQ TVFMMSSAAE VYERFASSHS ESTLARVNWS IENAQSVLTA WQRNFSNLIY
DYANNTAENR QVHPMSGTSI NDMLEMFSEL NPTVMIVGYV LMVFYASFSL CSTDDGGVAS
GVGLAVCGCI LVTISSLAGL GCSMLLGVKF NPTTTQVVPF LSLGLGVDDM FLLLHNYRDI
ARQYQVDQIG MLLKETGLSA LLTSVNNILA FLVGALLPIP ALRSFCIQVA LVLLLNAITI
LTIYPALMTF DLARRKRRLL DVFCCIRAPQ PKSRLNSRSE PVSVVYEKVN NSGQMNKSNN
SNSVSKSPVG ENEPKKRRCH LTGITVENFL KYIYGPLITR TPVKIGIVVF NLVLVALSID
GVTKISLGLE LTDLIPKHTA PYGFLAAREA YFSFFPFSAV LKGPMDIPHK QRLIREYRSA
IGEIDYVIRH DGQPSEKYWL SMMTEWLVSL QQKFDEDWQK GYINRSGVIS TLVSNDAKLA
YKLLCNQGDI LDCGRVGTTR LIDREGLINP DGFYNYLTAW FNLDQMSYYI SQANFYPQPP
IWYNTDHIRS DTDNKVPPAV CPTVSHIPFF VTNLVDTASV VDLINKVRSI CEEYTAMGLP
NFPEGLPFNF WEHYVHLNRN LLLALLMISA SVFVIVSLLL FSPWTALLVV TVVDLMVFEL
AGFMGMIGLK MNPVSAVTLI TAVGIGVEFT VHMSLSFLTA LGNRDQRVQM AVDHMFVPVL
HGGLSTLLGL IMLAFSEFEF IVHYFFLVMS CLILLGIING LFLFPVLLSW LGPPGEVRTI
DGSDSLPPPS PSLVAKQLAS LSKKSNQGAY FGLARASQKG YRRQSDMSLS TITEERTPPN
SATPPVLTIT PVQVIIHSKR SSIGIAGNNS PAVEVTSSTV TPRIHSSLPN VTNDLTQMEN
GEDGRSNRFS NAFTRFGNSI RRSLGHQSQQ KPV
//
