ID   A0A0V1AWQ6_TRISP        Unreviewed;      1470 AA.
AC   A0A0V1AWQ6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Dipeptidyl peptidase 8 {ECO:0000313|EMBL:KRY29224.1};
DE   Flags: Fragment;
GN   Name=Dpp8 {ECO:0000313|EMBL:KRY29224.1};
GN   ORFNames=T01_12804 {ECO:0000313|EMBL:KRY29224.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY29224.1, ECO:0000313|Proteomes:UP000054776};
RN   [1] {ECO:0000313|EMBL:KRY29224.1, ECO:0000313|Proteomes:UP000054776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS3 {ECO:0000313|EMBL:KRY29224.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY29224.1}.
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DR   EMBL; JYDH01000177; KRY29224.1; -; Genomic_DNA.
DR   Proteomes; UP000054776; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR025066; CCDC174-like.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF13300; DUF4078; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054776}.
FT   DOMAIN          743..1105
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          1273..1470
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          473..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          247..274
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        478..507
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRY29224.1"
SQ   SEQUENCE   1470 AA;  169525 MW;  FD46C68ECFA62D9D CRC64;
     YENCKEIFLL VSRKCVKKRL PTEIFEIVFS LVNSERAVFQ CNLLCTAQCR IVQHLVKISP
     GGSSSTVLKQ HRCKLSCKDL QHRVRSLKIT ESGTVVTGCI GVCELERMRD LGSSDGDKRS
     VFLHLHVPQL APSLNIVCDS TVLFRFALRS EVNLNQIAVS LSRNIIVFRE MSGTMKPSVS
     TLFDLKAELH KRKELLAKKK DSNQYNASDL YVKGKPILAE RRRLMKEANT SKAAKKNLSD
     PEIFERERQL MQSKQKLQEK AALYEQLKAG IKKDEPDVYN ETTYLVNFEQ KDKLQSSSDS
     EVSDEESSLS SKKSFEASKL GDEWVEYTDF AGRNRVCLKK DLPKMKAIDD KNSLRSQHGV
     SWNSETELMS KDMKRELQRQ KWENEVTSST GAAPVHYQHV LGNEPIVHGA SYYEFSLDEQ
     KRQEQMKMLD EARQQTLIHR AKNERIREKR KLLLKARLEK VAERRQIGSF PELFPNMTED
     EKNVDDIPMP DDAPDEQKAE DEERAKRRAI HVRPWDEIKK KRTSWIEERR EERDPEFAPP
     NLEHRTEENA PKMDEETSKQ RKEYSFPELL ELSHLYRMEV DLRDWYFRTH YLTFRSFIER
     LDHQDAIDHL PKLENSPHLP NDRIFRLYSF GFLERELGSR LLYTDIVVDR NCKLRSVGPP
     FWKTLCNTYV RIVRRHPPTD DSRDHIIQYP LDFNMCKFSR HVASNSFYYS QESRLMRLVD
     EVPLDKRRIQ CLVNIDPLVP ENITVCPGNE RLFAFVADRN VHVSTGAVPV TLEHSPSRQS
     WSYGLPPYII REEFNRQEGF WWSPTSNGNE YFLLVEGYND KMLPSILLSD YTMSPDKFEC
     LPYAFAGEQA DYLNLLLLYC AIDLGGLNPK WCVKVYSVIF KYRTSFPDVE VWERNFPERL
     IKLVPWAEYL VNAGWLPDGS AIWLKVMDRL QRRVSVICIP LEWFLPNDCA DNNDVRKADA
     QKHLVFLYTE ESDTWIPNHF GIKFLTPVSP DTVRFIWCSW KTDYRHLYLV ESRRTASVEE
     NFGTPTLDTT PTVLSEKQLT FGQWDVFSDM QAKFFCFFST STNSNVVMNV GILPSVSVDE
     KRSLIYFLGF ADNPLESHLY ATSYICPTTK PIRISTLGSF YGNTDEGNPF GFSNDYTLLA
     VFRSNFVTPG ECVIYALKFE TFFSNDLKYV LPSAASHLII SVAPYPAMNG VCPLPPPVRI
     FHESIWSRFT SEVSPPQLLE CEGPDGGYQL QCMLFTPSNV AVATPRPTIL FVYGGPCAQM
     VRNCWPTFLC LPLFMKMGYV VLVVDGRGSA YRGKQLEIAI GGRMGCVEIE DQVHALRYVA
     SQNKCIDMKR VVVMGWSYGG YLAINALAKH PNLFKIAISG APVVDWHLYD SAYTERYMGM
     PEEHEDNYNK ASLLNSISLL PDEPNRLLLM HGLKDQNVHF KHTALLIEAM ISAGKPYQLK
     IFPNERHGLR RASAIEHMSA TILHFLQENL
//