ID A0A0V1AXI6_TRISP Unreviewed; 988 AA.
AC A0A0V1AXI6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN Name=GLCE {ECO:0000313|EMBL:KRY29036.1};
GN ORFNames=T01_16065 {ECO:0000313|EMBL:KRY29036.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY29036.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY29036.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY29036.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY29036.1}.
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DR EMBL; JYDH01000183; KRY29036.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1AXI6; -.
DR STRING; 6334.A0A0V1AXI6; -.
DR eggNOG; KOG3760; Eukaryota.
DR InParanoid; A0A0V1AXI6; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF21174; Glce_b_sandwich; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 854..988
FT /note="DALR anticodon binding"
FT /evidence="ECO:0000259|SMART:SM00836"
SQ SEQUENCE 988 AA; 114606 MW; 16A131CB2A81F527 CRC64;
MKATQFKEMS LKRLKFVSAV CLTICFALGY KLFLICDRFN NWDVERRKIF YFTPSPVMHL
PGVYGESKVL AMEDDVLPVV CQINGKRTVR CLEDVEHGEV YMPFKSFLQP YFDHSFAKIQ
QPSFSTYRAD SVFGQFGTYN VAERFRVRCI NSKSGVPMSV QWSQRGYYYP VQIGQYGLEH
YSRSIIEPMP HVQYIAGLSE KRCFVEGQQT ITIQNSSELS VLRMFVLSSD RESSFHITVQ
RSDTKQLYRI HYIPAAEPIR VINSFDVYFG FGQLPKNRWI RFTRDLGVDL MHGIGYTSKR
MKKVKLKAIK LVILQLAFAG ELCVANVSLQ THAHVDHFLD VANWFVENQD RKGGWSVPVK
RSMSNGRLVL KPGWYSAMAQ GHAMSVLCRA YLLENKKEYL DSALKAVQLF YINASDGGLI
NYFYNVFPWY EEYPTTPGSF VLNGFIYSLI GLRDLAFCSE RVNQQVLDIY KIGLNSLKNM
LPLYDTGVGS LYDLRHVSLH GAPNVARWDY HAVHIFQLHW LYIIEGDELF KETANRWIRF
SEALLQKSSA RCSYPILSLP MIYCYVDVIF WLWQFSSILT GSNNNYCGKA LSYQNTDKEC
CLQIDQLGRL EIMESDFVER FNSLRINTPR QDELKQQCSL FCCITCGLIE KNEFTALRCL
LLTCHMEKWL VRNGFDVQVV MLCPKVSSWF SDFGFLETKF NKEIFISKSL NCAEICRMNK
DELFSTVGKY FQTYQRKENA IFIIYSDLKG CNFQQLSQYF QNMQFVNYAY KIAHVKISIA
QFSVKCFLSE RKKQILERIE EKHGKVDSQD QIVSRLTALV VVFELLTAKH DQPVFISYPS
ENGLPAIARK ALFVMYNFTR MCSILNSFKK MVSKNYYPKL VPLALLSSDM QRGVLAEFRP
LTDMIFSFDI IHSGNGFRRS DFTVPKICHW LTNFTSQFSK IYSKIQILTP ATDLLFDELF
VKIHLIEMFH NTMKLMFNLL CLETLNGM
//
