ID A0A0V1AYC3_TRISP Unreviewed; 1849 AA.
AC A0A0V1AYC3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|EMBL:KRY29742.1};
GN Name=Megf6 {ECO:0000313|EMBL:KRY29742.1};
GN ORFNames=T01_1685 {ECO:0000313|EMBL:KRY29742.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY29742.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY29742.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY29742.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY29742.1}.
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DR EMBL; JYDH01000162; KRY29742.1; -; Genomic_DNA.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 8.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035:SF109; INTEGRIN BETA-LIKE PROTEIN A-RELATED; 1.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF00053; Laminin_EGF; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 24.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS00022; EGF_1; 16.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 154..235
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 398..434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 477..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 645..685
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 835..865
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1273..1308
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1316..1351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1359..1394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1402..1437
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1531..1566
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1579..1609
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1617..1652
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1703..1738
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 855..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1298..1307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1341..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1384..1393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1427..1436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1556..1565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1599..1608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1642..1651
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1728..1737
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1849 AA; 201147 MW; 0E86C042F0732D38 CRC64;
MAEVFSADLS RNAIFGLRAE ICQPARLLNN NRVVGRSDRF DGGRTAAALS TLPLAFIFQS
VPPPESRSTP PSDLPTLIDI NMYAYIYIYE MFYKRFGQAT IQQRSLLTVL DLSSLIISGL
MMHHRLVIVL FFLFSLLTTS WSVELEVEEL KPDMKNVCPH EEVEVVTIQE PCIQAYTRYV
RRWKPNCDHQ KRWCVISEPK TIYYRTVKTK QRKERHVRYK CCYGWLPVTG EGCTKRKDSP
SLLINVNFVH GPPEIEAQPN RDSRGQGSVV ELITVTVELP RRAADPFQFA QVICGGSEGE
GEGAGGGDGS VGSIDCRLSV SRRQWCGDVP KEAVDLNNAE KLKKRKQMLL FKSAFFSLRK
YLQQLFPHFH PIVKQNLRIH FFFICKFITP TNDNGTVHYS NCTTDLCYNG GSCSSAVAAR
LCDCPPGFQG SRCQYDINEC LVDNGGCHHD CSNTIGTFYC RCWPGFQLNS DGKTCVDVNE
CEVVNGGCEY RCVNTNGGYR CECPPNKQLH PDGRHCINEN SCELNNGGCS QLCQEEGGKF
LRCRCHAGYR LADDKRTCYD VNECELHHRG GCEQLCVNIP GSFECQCHEG YRLASDRKRC
IKLQASCEVN NGGCEHHCTA SVDGGVQCNC KHGFRLADDG KHCVDIDECV NNNAGCDHQC
HNQPGSYYCA CRPGFHLSID QHSCEDINEC LTNNGNCQQL CTNVPGSYRC ECFLGYSLDG
DKKSCNALYL VRSLKSNESS DPFQLNLFNN KTEYHLELPQ SAAAVHQYSH LYNYGLNQQE
CPIGKFGFKC EYSCDDCQNG GRCNRKQSGC DCRAGWIGII CNESCPEGFW GIGCSNVCSC
SNGGLCNPIT GECRCLAGYS GESCEVGCPA GYYGPRCDLP CRMQCPNNIC DRTYGYCPCS
PGFFGKKCEQ TCPPFTYGRN CRHLCKCHRE NSVGCNEQTG ECYCKDGFYG PYCKATCPLG
YYGPSCRKQC ACEVSVGCDP VSGMCEPKCK PGFTGPDCKQ PCPPNRFGVN CASVCQCPKE
QKCHPASGAC TCPAGFTGTK CSQKCPPNRY GPMCMYECVC KNGASCDPET GRCQCTAGFY
GTACTEKCPP GRFGRDCMEL CSCMNGAACD PVNGSCACLA GWQGELCDRV CDANTFGANC
AQSCNCTGDV KCDPVSGDCI CPPGLQGERC DQPCPSGSYG AGCMGVCACK NGATCDAVSG
RCLCASGWRG WHCDRPCPDG FYGKQCAQIC DCGFGSQEGN GALSRCDHVT GECLCPSGWT
GPDCRTPCPP NRWGNGCTET CQCENGGSCD PLTGLCSCPP GWIGKACDQE CPAGLHGINC
AQHCHCLNNA TCDSRTGKCL CSPGWMGAAC EFRCPFGYFG PSCNGVCQCQ AGAACDHVTG
ECRCLPGWTG ERCDKKCPDG KYGINCSEVC QCEHGASCHH ITGHCLCTPG WRGRRCHRPC
IKGYYGRNCA QRCNCPKQNN CDHITGQCSC PAGYTGPTCS HLCPEGKFGQ DCHSRCSCSA
NANCDPVTGD CICKPGFSGP GCNEGCVQGK FGFDCKENCT CENGGICDSV FGKCTCPSGF
IGTMCEMPCP SNRHGINCIE ECPCENGGTC SRTTGQCVCP PGFTGINCKL VCPETKYGAG
CAEKCRCKNG GFCNPVDGTC KCTLGWTGPS CEQECPKGRY GAGCALECRC HNNAHCDRIT
GCCDCPDGFY GSMCEFKCPE GMYGWYCSKF CNCLNGAACD PTTGQCLCPP GFHGDKCEST
CPVGGYGVNC RLKCDCGDYD CDSTTGQCIC PLGFTGPRCQ DVCRSGRYGF NCEQSCKCYN
GARCNMFTGQ CECAAGWLGA TCQREDYSHN VLPSRGDVPN HVNRGYYRR
//
