ID A0A0V1AZS7_TRISP Unreviewed; 907 AA.
AC A0A0V1AZS7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Alpha-actinin, sarcomeric {ECO:0000313|EMBL:KRY29804.1};
GN Name=Actn {ECO:0000313|EMBL:KRY29804.1};
GN ORFNames=T01_505 {ECO:0000313|EMBL:KRY29804.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY29804.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY29804.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY29804.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY29804.1}.
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DR EMBL; JYDH01000160; KRY29804.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1AZS7; -.
DR STRING; 6334.A0A0V1AZS7; -.
DR eggNOG; KOG0035; Eukaryota.
DR InParanoid; A0A0V1AZS7; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 30..134
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 143..249
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 762..796
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 802..837
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 264..291
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 680..714
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 907 AA; 105920 MW; A5C64FBC859A0554 CRC64;
MLYYGDTNYD YMQQEEEWDR EGLLDPAWEK QQKKTFTAWC NSHLRKADTM IENIEEDFRN
GLKLMLLLEV ISGEELPRPD RGKMRFHKIA NVNKALAFIE SKGVKLVSIG AEEIVDGNVK
MTLGLIWSII LRFAIQDITI EELSAKEGLL LWCQRKTAPY RNVNVQNFHT SWKDGLAFCA
LIHRHRPELL DYDNLSKDDP LYNLNLAFDT AEKYLDIPKM LDAEDMVYVA KPDDKAVMTY
VSCFYHAFRG AQQAETAANR ICKVLKVNQD NERLMEEYEQ LATDLLEWIR RWLPWLKNRT
TDGTLKNVQQ MLNEFRQYRR REKPPRIEQK GRLETNFNTL QTKLRLSNRP AYLPTEGKMI
QDINGAWKNL LNAEKGFEEW LLSEMMRQDI SFFFNKYIAF DCRLERLEHL AEKFRRKCAI
HEEWAQGKEQ MLSSGDYKGS YLYELKALRK RHEAFESDLA AHQDRVEQIV AIAQELTALH
YVDIVSVNAR CQRICDQWDR LGMLSNKRGQ NLKDAEILME RIDNLHLELA KRAAPFNNWL
DGATEDLQDM FIVHTMSEIQ SLAHAHDQFK ATLGEAEEEF RHIIGLEQEV RHLVESNGLN
REMAVNPYTT ISGAEIQKKW QHMQILVPNR DNQLQQEMNR QQSNDRLRRT FAEKANAVGP
YLEQQLSQVA TIALGGRGSL EQALQRLLDL YRSVENYKLN MDELERINQQ LQESYICENP
FTQYTMETLY VGWETLLTNI NKTINEIENQ ILTRDTKGIR DDQLNEFRTS YNHFDKSRLG
LDAEEFKSCL ISIGYNIKPG REGDMEFQRI LTVVDPNRTG RVQFDAFLDF MTRETLDMDS
SEQVIESFRV LANGKPFITA EELRHELPPD QAEYCVQKMP AYRGPGAPPG SFDYVSFSHQ
LYGESNL
//
