ID   A0A0V1B7B1_TRISP        Unreviewed;       459 AA.
AC   A0A0V1B7B1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 2 {ECO:0000313|EMBL:KRY32879.1};
GN   Name=ERGIC2 {ECO:0000313|EMBL:KRY32879.1};
GN   ORFNames=T01_15359 {ECO:0000313|EMBL:KRY32879.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY32879.1, ECO:0000313|Proteomes:UP000054776};
RN   [1] {ECO:0000313|EMBL:KRY32879.1, ECO:0000313|Proteomes:UP000054776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS3 {ECO:0000313|EMBL:KRY32879.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004457}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ERGIC family.
CC       {ECO:0000256|ARBA:ARBA00005648}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 28 family.
CC       {ECO:0000256|ARBA:ARBA00005571}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRY32879.1}.
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DR   EMBL; JYDH01000091; KRY32879.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1B7B1; -.
DR   STRING; 6334.A0A0V1B7B1; -.
DR   InParanoid; A0A0V1B7B1; -.
DR   Proteomes; UP000054776; Unassembled WGS sequence.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046907; P:intracellular transport; IEA:UniProt.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   InterPro; IPR021640; Mediator_Med28.
DR   PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR   PANTHER; PTHR10984:SF30; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
DR   Pfam; PF11594; Med28; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..93
FT                   /note="Endoplasmic reticulum vesicle transporter N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13850"
FT   DOMAIN          166..340
FT                   /note="Endoplasmic reticulum vesicle transporter C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07970"
FT   COILED          415..442
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   459 AA;  53563 MW;  41C268B8FBADE4D2 CRC64;
     MFGVRQRKKP VISFMERLDA FPKIRQSVRM EYSASHVFLA FLVIVIWLIY CEFLYFSEIY
     YAYTFTVDTS FKDQLTLYVD LTVATKCEYL ATSMDGVKQK SLASSEEVSM VPVRFKLSPD
     AQLYWNMLRN VRELHVPERL HHLSERNSLG FEIWRHLHEF AVDRQNNASS TETAIVDACR
     IHGYFLMNKL RGKLRIKFKE TVRLEAVSNF IIFARRQNEG FNFSHRIEKF GFGPRIAGII
     NPLDGFQKES FDRRDMFYYY IQVVPTKITD LNGMETFTSQ YSVTHKRRII DHDQGSHGSC
     GIFIYFDFAP MMVLIRKSKT SLFVFALRIC AIVGGIFACT GNCMEEYNGD VINNFRQAVK
     SCLTLLSVPV KSRHIEADEI KTTAEVATHR LIEAARRSER HFVRLYALFS AYCPEEVLKE
     EINEMKQEIE RKKNMLLKHE EKMIAWEQIL SEAETPLTS
//