ID A0A0V1BB28_TRISP Unreviewed; 545 AA.
AC A0A0V1BB28;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
DE Flags: Fragment;
GN Name=Frmd8 {ECO:0000313|EMBL:KRY34233.1};
GN ORFNames=T01_1052 {ECO:0000313|EMBL:KRY34233.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY34233.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY34233.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY34233.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY34233.1}.
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DR EMBL; JYDH01000070; KRY34233.1; -; Genomic_DNA.
DR EMBL; JYDH01000070; KRY34235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1BB28; -.
DR eggNOG; KOG3946; Eukaryota.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR040233; CCD97-like_C.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF6; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR Pfam; PF09747; CCD97-like_C; 2.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KRY34233.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..545
FT /note="glutaminyl-peptide cyclotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007438152"
FT DOMAIN 110..294
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 388..466
FT /note="CCD97-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09747"
FT DOMAIN 472..542
FT /note="CCD97-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09747"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY34233.1"
SQ SEQUENCE 545 AA; 65276 MW; 947D252648FE8572 CRC64;
LFFEMFLIFG TLFLFSFSFC EPSQNNWKLT QATHQIRNYE QEQLLQLCAL SDHERFRNYL
KYILIPRPVG SRNHKKVQEF ITQSLEALGY KVESTTFTQQ TVVGQKTFTN IVGTLDPLIP
RRLILACHYD SKDFRPNFEF FGATDSAVPC AMLLDIAASL RNVIYNRKSK DLTLQLIFFD
GEESFREWSD TDSLYGSRYM VKELEKRPYP EYYSPRNRDL DRIDLFVLLD LIGAKGSTFY
YHYPYSVLNA YTVLPETERQ LKASRNCIYD LPTIFHDLMI NTFIQDDHLP FLEKAERLDN
LFKRIANIPE AFFRDQQRGE ADFTFEQRLN IVRSTYEQMP VKFLSKYSCY IEKGELDLFE
PYSDQTMEYH IERIKNSGTK EAAFRIKNRR FSKLKQLISE GTYFSDREMR QRDPWLYYHM
IGRFLTENES KALFYSQNSQ YKFSDLLLDF HDNKKVNDER VKRENSYRKE PKKFFSYETK
KTETTISEEE KERLRKEFVI IMHESFLEGR DKEFDYSEVD ENSKYDDYVR INQDAEDKYF
EDSDD
//
